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a point » _ point (Expand Search), 5 point (Expand Search), _ points (Expand Search)
5 c » 25 c (Expand Search)
point decrease » point increase (Expand Search)
nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
c decrease » c decreased (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
a point » _ point (Expand Search), 5 point (Expand Search), _ points (Expand Search)
5 c » 25 c (Expand Search)
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Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model
Published 2024“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. The anti-mTNF conjugate <b>ADC5</b> fully inhibited inflammation in mouse contact hypersensitivity with minimal effects on corticosterone, a biomarker for systemic GRM effects, at doses up to and including 100 mg/kg. …”
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Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model
Published 2024“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. The anti-mTNF conjugate <b>ADC5</b> fully inhibited inflammation in mouse contact hypersensitivity with minimal effects on corticosterone, a biomarker for systemic GRM effects, at doses up to and including 100 mg/kg. …”
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Pep4 overexpression decreased APCs in Vps21- and ESCRT-mutant cells after nitrogen starvation.
Published 2022“…<p><b>A.</b> The accumulation of GFP-Atg8-labeled APCs in mutant cells (<i>vps21Δ</i>, <i>snf7Δ</i>, and <i>vps4Δ</i>) slightly decreased with Pep4 overexpression. …”
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