Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution by Massimiliano Gaetani (241969)

“…Compared to standard approaches where curves are fitted to protein solubility data acquired at different temperatures and drug concentrations, Proteome Integral Solubility Alteration (PISA) assay increases the analysis throughput by 1 to 2 orders of magnitude for an unlimited number of factor variation points in such a scheme. The consumption of the compound and biological material decreases in PISA by the same factor. …”

Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution by Massimiliano Gaetani (241969)

“…Compared to standard approaches where curves are fitted to protein solubility data acquired at different temperatures and drug concentrations, Proteome Integral Solubility Alteration (PISA) assay increases the analysis throughput by 1 to 2 orders of magnitude for an unlimited number of factor variation points in such a scheme. The consumption of the compound and biological material decreases in PISA by the same factor. …”

Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution by Massimiliano Gaetani (241969)

“…Compared to standard approaches where curves are fitted to protein solubility data acquired at different temperatures and drug concentrations, Proteome Integral Solubility Alteration (PISA) assay increases the analysis throughput by 1 to 2 orders of magnitude for an unlimited number of factor variation points in such a scheme. The consumption of the compound and biological material decreases in PISA by the same factor. …”

Typical symptoms of water soaking in strawberry ‘Florentina’ after incubation in (A) water (score 3) and in (B) 10 mM of CaCl₂ (score 2) for 8 h. by Grecia Hurtado (10798260)

Conditional PyLT expression induces cell cycle progression, an increase in cyclin A and a decrease in p21 in ICI treated cells. by Hemant Varma (30590)

Table 1_Subjective spatial orientation discomfort is associated with decreased real-world spatial performance and lower cognitive function.docx by Johannes Gerb (10287758)

The phosphorylation sites we identified in both ULK1 and ATG13 are conserved between different isoforms. by Zhiyuan Li (205620)

An outline of our methodology. by Krishna Bathina (12883820)

Units of non-point source agricultural pollution. by Cangyu Li (10312677)

“…Specifically, there was a increase in total pollution over the 2001–2006 period, followed by a fluctuation, continuous decrease, and stabilization in the 2007–2013, 2014–2019, and 2020–2023 periods, respectively. …”

Study selection criteria. by Filip Stanicic (17808254)

“…Durability was observed in a long-term follow-up trial (mean duration, 45.4 months) with a 0.9-point CAPS decrease from post-treatment.…”

PICOS criteria for the SLR. by Filip Stanicic (17808254)

“…Durability was observed in a long-term follow-up trial (mean duration, 45.4 months) with a 0.9-point CAPS decrease from post-treatment.…”

PRISMA flow chart. by Filip Stanicic (17808254)

“…Durability was observed in a long-term follow-up trial (mean duration, 45.4 months) with a 0.9-point CAPS decrease from post-treatment.…”

Bootstrapped LIWC negative word ratio (LWNR) around the hit date for each hurricane and location. by Krishna Bathina (12883820)

Bootstrapped VADER sentiment around each hurricane and location. by Krishna Bathina (12883820)

(A) The temperature sensitive allele of <i>HEM1</i> leads to a significant decrease in the endogenous levels of Cia2 and Mms19. by Ifat Lev (469072)

Bootstrapped LIWC positive word ratio (LWPR) around the hit date for each hurricane and location. by Krishna Bathina (12883820)

A prepubertal CD decreases hepatic DNA methylation and increases hydroxymethylation in adulthood despite a chronic HFD in Sprague-Dawley male rats. by Ana Aguilar-Lozano (20614619)

Results of comparison between Model5 and Model10. by Taiga Mori (21410076)

“…We then define the magnitude as the difference between the lowest and highest points of the head within a cycle. In the analysis, we demonstrate that this magnitude varies depending on length and position, thereby providing evidence that nods exhibit a structured pattern. …”

Table_1_Cycling Quiescence in Temozolomide Resistant Glioblastoma Cells Is Partly Explained by microRNA-93 and -193-Mediated Decrease of Cyclin D.XLS by Jessian L. Munoz (6389198)

“…The data provide a number of therapeutic approaches to reverse chemoresistance at the miRNA, exosomal and cell cycle points.…”

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)