Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution by Massimiliano Gaetani (241969)

“…Compared to standard approaches where curves are fitted to protein solubility data acquired at different temperatures and drug concentrations, Proteome Integral Solubility Alteration (PISA) assay increases the analysis throughput by 1 to 2 orders of magnitude for an unlimited number of factor variation points in such a scheme. The consumption of the compound and biological material decreases in PISA by the same factor. …”

Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution by Massimiliano Gaetani (241969)

“…Compared to standard approaches where curves are fitted to protein solubility data acquired at different temperatures and drug concentrations, Proteome Integral Solubility Alteration (PISA) assay increases the analysis throughput by 1 to 2 orders of magnitude for an unlimited number of factor variation points in such a scheme. The consumption of the compound and biological material decreases in PISA by the same factor. …”

Resveratrol decreases CYP17A1 and CYP21A2 protein expression. by Nesa Marti (3851059)

FASN inhibitors result in decreased ΔΨm and increased superoxide production in melan-a cells. by Franco A. Rossato (588513)

FASN inhibitors result in decreased ΔΨm and increased superoxide production in melan-a cells. by Franco A. Rossato (588513)

Mean T2* and T2 relaxation time of the 10 participants. by Charlotte Zaeske (12101949)

Mean T2* and T2 relaxation time of the 10 participants. by Charlotte Zaeske (12101949)

A hypoglycaemic <i>milieu</i> decreases NCS viability in a dose-dependent manner. by Shiva Mansouri (2838086)

HDAC1 knockdown significantly increases RGS10 expression while HDAC1 overexpression decreases RGS10 expression in chemoresistant ovarian cancer cells. by Ercan Cacan (393523)

“…<p><b>A)</b> Knockdown of HDAC1 increases RGS10 mRNA transcription. …”

Expression level differences between constructs. by Xinwen Zhu (14709669)

Chronic exposure of human PAC to nicotine decreases carrier-mediated [³H] thiamin uptake. by Padmanabhan Srinivasan (481324)

A 3-D plot showing the mean time (s) of fighting behavior in the dark-to-light transition sessions at different days, in 1-minute epochs. by Piotr Popik (292215)

A 3-D plot showing the mean time (s) of fighting behavior in the light-to-dark transition sessions at different days, in 1-minute epochs. by Piotr Popik (292215)

The phosphorylation sites we identified in both ULK1 and ATG13 are conserved between different isoforms. by Zhiyuan Li (205620)

Oleic acid treatment decreases MDA formation, and induces UCP2 and AMPK in septic mice. by Cassiano Felippe Gonçalves-de-Albuquerque (846954)

Linking gene of interest to hygromycin expression cassette lowers overall expression. by Xinwen Zhu (14709669)

An outline of our methodology. by Krishna Bathina (12883820)

Units of non-point source agricultural pollution. by Cangyu Li (10312677)

“…Specifically, there was a increase in total pollution over the 2001–2006 period, followed by a fluctuation, continuous decrease, and stabilization in the 2007–2013, 2014–2019, and 2020–2023 periods, respectively. …”

(A) The temperature sensitive allele of <i>HEM1</i> leads to a significant decrease in the endogenous levels of Cia2 and Mms19. by Ifat Lev (469072)

Order effects are milder for P2A compared to T2A. by Xinwen Zhu (14709669)