The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets by Cenciarelli, Carlo

“…In the last decade Stat3 has gained attention as therapeutic target in cancer but there is not yet any approved Stat3-based glioma therapy. Herein, we report that exposure to a Stat3/5 inhibitor, induced apoptosis either in shHes1-CSC or control cells. …”
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Electrical characteristics and density of states of thin-film transistors based on sol-gel derived ZnO channel layers with different annealing temperatures by Wang S.

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Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2. by Thirumal Kumar, D

“…The D-2-HGA includes two subtypes: type I and type II caused by the mutations in D2HGDH and IDH2 proteins, respectively. In this study, we studied six mutations, four in the D2HGDH (I147S, D375Y, N439D, and V444A) and two in the IDH2 proteins (R140G, R140Q). …”
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Effect of hyperglycemia on EPCs function and regenerative ability by Hendawi, Hadeel Khalil

“…This research aims to test the EPC subtype blood outgrowth endothelial cells (BOECs) and their ability to survive and function under chronic hyperglycemic conditions. For that, we studied BOECs viability, response to shear stress, angiogenesis ability, and barrier function under normoglycemic (5.5mM) and hyperglycemic (25mM) conditions. …”
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Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response by Xue, Mingzhan

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Superior photocatalytic activity of Cu doped NiWO4 for efficient degradation of benzene in air even under visible radiation by Tri N.L.M.

“…This was because Cu effectively acted as novel dopant, which not only affected valence band (VB) top and conduction band (CB) bottom of NiWO4 but also formed a medium energy level between CB and VB of the NiWO4 to decrease its energy band gap and electron-hole recombination rate. …”
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Roadmap toward energy-positive upfront nitrogen removal process in baseload LNG plant by Mkacher, Hajer

“…The results show that UNrem of 87.5% from the NG feed can reduce the total power requirements by 0.24%, increase the production flow rate by 4.4%, and decrease the exergy losses by 0.23% compared with the base case. …”
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Modeling of dual-metal Schottky contacts based silicon micro and nano wire solar cells by Rabbani, M. Golam

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Utilization of Emergency Services by Children with Asthma in Qatar by Arafah, Dima

“…Respiratory diseases are the most common conditions seen in Pediatric Emergency Centers (PECs) in Qatar. 2 The five PECs are an essential point of healthcare access for severely sick children, however, many people utilize them for potentially preventable reasons. 3 Methods: This was a quantitative retrospective observational study of children with asthma utilizing the five PECs during 2019. …”
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Antibiotic Prescription Patterns for Upper Respiratory Tract Infections in Outpatient Qatari Population in the Private Sector by Butt, Adeel Ajwad

“…During the study period, health insurance was limited to Qatari nationals. We excluded topical antibiotics. We also retrieved data on prescriber’s specialty as listed with the licensing authority. …”
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Effect of mobile text messages on antiretroviral medication adherence and patient retention in early HIV care: An open-label, randomized, single center study in south Florida by Sherman, Elizabeth M.

“…Background People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. …”
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Integrated planning of spare parts and service engineers with partial backlogging by Rahimi-Ghahroodi, S.

“…In a numerical study, we show that for problems with more than five types of spare parts it is preferable to use approximate evaluations as they become significantly faster than exact evaluation. …”
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Evacuated tube heat pipe solar collector for Encontech engine-driven reverse osmosis solar desalination by Takalkar, Gorakshnath

“…Both energetic and exergetic efficiencies exhibit upper values at A co/A abs ratio up to 1. Further increment in this ratio up to 3 resulted in a decrease in the efficiency of the ETHPSC.…”
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Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis by Manresa M.C.

“…Background When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. …”
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Higher egg consumption associated with increased risk of diabetes in Chinese adults - China Health and Nutrition Survey. by Wang, Yue

“…The association between egg consumption and diabetes is inconclusive. We aimed to examine the association between long-term egg consumption and its trajectory with diabetes in Chinese adults. …”
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Overconfident results with the bivariate random effects model for meta-analysis of diagnostic accuracy studies by Furuya-Kanamori, Luis

“…In 2001, Rutter and Gatsonis proposed the hierarchical summary receiver operating characteristic (HSROC) model,1 and in 2004 Macaskill described an empirical Bayes approach.2 Soon after, in 2005, Reitsma et al. proposed the bivariate random effects model,3 which has been widely adopted and is the most commonly used method for diagnostic meta-analysis.4 However, as pointed out by Diaz,5 the statistical performance of the bivariate model has not been scrutinized. …”
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Nanoclay compatibilization of phase separated polysulfone/polyimide films for oxygen barrier by Ammar, Ali

“…Herein, we quantify the effect of a nanoclay, Cloisite 30B on the phase separated blend film morphology compatibilization of PSF/PI and associated changes in its mechanical properties and film surface energy. …”
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Dynamic Imaging of Hydrate Specific Area Evolution during Xenon Hydrate Formation by Jarrar, Zaher

“…During hydrate formation and dissociation, full 3D images are acquired at a time resolution of 45 seconds and a spatial resolution of 5.38 ?…”
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Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein inter... by Thirumal Kumar, D.

“…From the analysis, we observed the highest deviation with lowest compactness and a decrease in the intramolecular h-bonds in the BRCA1-BARD1 protein complex with the V11G mutation compared to the native complex or the complexes with other mutations. 2022 Elsevier Inc.…”
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Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2. by P, Sneha

“…Molecular docking analysis revealed a decrease in interaction between the protein and ATP in all the 3 mutations, and molecular dynamic simulations of 50 ns showed a loss of stability and compactness in the mutant proteins. …”
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