Identification of a mitochondrial respiratory chain deficiency and defective mtDNA translation. by John W. Yarham (573109)

“…<b>E</b>) <i>In vitro</i> metabolic labelling of mitochondrial translation in patient fibroblasts (P) showed a generalised decrease in translation activity, with the subunits of Complex I (notably ND5) and Complex IV (notably COXI) most substantially decreased. …”

Illustration of the visual field of the model. by Emre Akbas (4500565)

CB2R negatively regulates NLRP3 inflammasome activation in peritoneal macrophages stimulated with LPS/DSS. by Ping Ke (3110763)

Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model by Jo Sourbron (1907299)

“…We also provide evidence that zebrafish larvae express the orthologues of all human 5-HT receptor subtypes. Using an automated larval locomotor behavior assay, we were able to show that selective 5-HT_1D-, 5-HT_1E-, 5-HT_2A-, 5-HT_2C-, and 5-HT₇-agonists significantly decreased epileptiform activity in the mutant zebrafish at 7 days post fertilization (dpf). …”

Rapid regrowth and detection of microbial contaminants in equine fecal microbiome samples by Kalie F. Beckers (4559983)

“…Sampling at various time points (0, 2, 4, 6, 12 h) had a significant effect on both diversity and community composition of fecal samples. …”

An Illustration of how Reading to a Dog may Influence Reading Performance. by Sophie Susannah Hall (2137030)

“…⁵In reading studies motivation is often discussed in terms of intrinsic motivation (motivated from within; e.g., curiosity to read, enjoyment of the experience) and extrinsic (motivated by external factors; e.g., to get a good grade) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149759#pone.0149759.ref077" target="_blank">77</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149759#pone.0149759.ref078" target="_blank">78</a>]. …”

Viewpoint of Medical Students from a Public University on Health and Quality of Life by Angela Maria Moreira Canuto Mendonça (8303655)

“…Discussion The decrease in the quality of life is a result of the curricular matrix with more than 8,000 hours. …”

State space variation centered on spike events. by Evan Cudone (5768813)

MiR-330 overexpression induces a downregulation in the levels of p-Akt. by Becky A. S. Bibby (776954)

Pain reports. by Jesse M. Charlton (5495855)

Rates of microsaccades around the time of a perceptual switch (time 0). by Po-Jang Hsieh (251896)

“…<p>(a) The rate of microsaccades rises before and after perceptual transitions from ‘no see’ to ‘see’, and decreases before perceptual transitions from ‘see’ to ‘no see.’ …”

cKO embryos display a variety of defects in the yolk sac mesoderm. by Siyeon Rhee (390224)

“…<p>A–B, D–E) Whole mount immunofluorescence of 9.5 <i>dpc</i> WT (A–B) or mutant (D–E) yolk sacs (YS) using the endothelial marker PECAM (green) and the vascular smooth muscle marker (αSMA) demonstrates that the large disorganized vessels in the cKO (D) are not surrounded by αSMA (E). …”

Table2_Enhanced Transgene Expression by Optimization of Poly A in Transfected CHO Cells.DOCX by Xiao-yin Wang (11992034)

“…Importantly, the SV40 and Synt poly A elements decreased the variation of eGFP transgene expression. …”

Table1_Enhanced Transgene Expression by Optimization of Poly A in Transfected CHO Cells.DOC by Xiao-yin Wang (11992034)

“…Importantly, the SV40 and Synt poly A elements decreased the variation of eGFP transgene expression. …”

A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between <i>osm-3</i> and <i>nphp-4</i> by Svetlana V. Masyukova (849325)

“…Four loci have been identified, three of which are established ciliopathy genes <i>mks-1</i>, <i>mks-2</i>, and <i>mks-5</i>. The fourth allele (<i>yhw66</i>) is a missense mutation (S316F) in OSM-3, a kinesin required for cilia distal segment assembly. …”

Modality-specific biases in spatial perception. by Fangfang Hong (11707989)

Rates of microsaccades around the time of a perceptual switch (time 0). by Po-Jang Hsieh (251896)

Quality of Life and Costs in Parkinson's Disease: A Cross Sectional Study in Hungary by Gertrúd Tamás (328848)

“…The total mean cost was €6030.2 (SD = 6163.0)/patient/year (direct medical 35.7%, direct non-medical 29.4%, indirect cost 34.9%). A one year increase in disease duration and 0.1 decrease of the EQ-5D utility score increase the yearly costs by 8 to 10%, and 7.8%, respectively. …”

SERBP1 is a component of the Liver Receptor Homolog-1 transcriptional complex by Yelenis Mari (725499)

“…In contrast, receptor overexpression decreased only SERBP1 mRNA levels. Consistent with these data, in a promoter:reporter assay, binding of NR5A2 to the promoter region of SERBP1 resulted in a decrease in the expression level of the reporter gene, and subsequently, inhibiting transcription. …”

SERBP1 is a component of the Liver Receptor Homolog-1 transcriptional complex by Yelenis Mari (725499)

“…In contrast, receptor overexpression decreased only SERBP1 mRNA levels. Consistent with these data, in a promoter:reporter assay, binding of NR5A2 to the promoter region of SERBP1 resulted in a decrease in the expression level of the reporter gene, and subsequently, inhibiting transcription. …”