The <i>I</i>_K1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat by Xu-Wen Zhai (4033601)

“…However, clinical anti-arrhythmic agents that primarily act on RMP by enhancing the <i>I</i>_K1 channel are not currently available. We hypothesized that zacopride, a selective and moderate agonist of the <i>I</i>_K1/Kir2.1 channels, prevents and cures acute ischemic arrhythmias. …”

Image_1_Optimizing estradiol level for gonadotrophin-releasing hormone antagonist initiation among patients with simple tubal factor infertility.jpg by Yizhuo Wang (5132726)

“…Through smooth curve fitting, we found that, with the increase of serum E₂ levels on the day of GnRH-ant initiation, CPR showed a trend of slight increase and then slight decrease. …”

Significant downregulation of <i>Cebpe</i> in human <i>Evi1</i> overexpressed leukemic cells. by Carolyn Glass (427882)

“…U937+<i>Evi1</i> cells had 8 point increase in Ct value (or 256 fold decrease) compared to the U937 wildtype cells (p<0.001).…”

Carbon Dynamics, Development and Stress Responses in <em>Arabidopsis</em>: Involvement of the APL4 Subunit of ADP-Glucose Pyrophosphorylase (Starch Synthesis) by Cécile Sulmon (86782)

“…This enhanced atrazine tolerance mutant was shown to be affected in the promoter structure and in the regulation of expression of the APL4 isoform of ADP-glucose pyrophosphorylase, a key enzyme of the starch biosynthesis pathway, thus resulting in decrease of <em>APL4</em> mRNA levels. …”

Additional performance tests also exhibited persistent deficits/changes after tMCAO. by Jin Zhou (90734)

“…<p><b><u>A</u>:</b> Hindlimb Placement performance deficits were significant and exhibited no spontaneous recovery of function (i.e., no decrease from the original d1 deficit) for the full 10 weeks of observation post-tMCAO. …”

Representative slices of the threshold-aware optimal policy (top row) and the corresponding probability of success (bottom row) for the Carrère example. by MingYi Wang (2807581)

“…Bottom row shows the probability of “eradication within the budget” if the optimal policy is followed from this time point and onward. Each column corresponds to a specific budget level <i>s</i>, which is shown below each square. …”

Effects of COS on retinal cell apoptosis. by I-Mo Fang (470460)

“…Treatment with low-dose or high-dose of COS caused significantly decrease in Bax/Bcl-2 ratio at day 7 and 14. (*<i>P</i> < 0.05 compared with PQ only or PBS-treated group; # <i>P</i> < 0.05 compared with normal; & <i>P</i>< 0.05 by ANOVA test with post hoc Bonferroni test; N=3 for each group in each time point).…”

Bicyclic α‑Iminophosphonates as High Affinity Imidazoline I₂ Receptor Ligands for Alzheimer’s Disease by Sònia Abás (3614849)

“…Acute treatment in mice with a selected compound significantly decreased Fas-associated protein with death domain (FADD) in the hippocampus, a key signaling mediator of neuroprotective actions. …”

Video1_Spectral Asymmetry of Near-Concentric Traveling Ionospheric Disturbances Due to Doppler-Shifted Atmospheric Gravity Waves.MP4 by Irfan Azeem (11169684)

“…Furthermore, our results show that the characteristics of the TIDs observed on April 28, 2014 in the TEC over CONUS are consistent with those of underlying AGWs being excited by a point source, such as a deep convection system.…”

Fig 3 - by Alexa Petrucciani (13262165)

“…<p>Spheroid (blue) and traditional (green) simulations have been calibrated in a paired manner to in vitro data. a) Bacterial count dynamics for spheroid and traditional simulations over the 6-day time course. …”

Loss of mesenchymal <i>Srg3</i> disrupted BMP signaling and caused defective chondrogenesis in forelimb buds. by Shin Jeon (2559289)

“…Red and black arrowheads point to anterior expansion and posterior decrease, respectively. …”

Video1_Spectral Asymmetry of Near-Concentric Traveling Ionospheric Disturbances Due to Doppler-Shifted Atmospheric Gravity Waves.MP4 by Irfan Azeem (11169684)

“…Furthermore, our results show that the characteristics of the TIDs observed on April 28, 2014 in the TEC over CONUS are consistent with those of underlying AGWs being excited by a point source, such as a deep convection system.…”

IPF fibroblasts are desensitized to collagen rich matrix induced cell death in the presence of 3MA or CQ. by Richard Seonghun Nho (54078)

“…All assays were performed in three separate experiments to measure fibroblast viability or their proliferation using IPF cells in lane 5 and control fibroblasts in lane 3 in an upper panel in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094616#pone-0094616-g001" target="_blank">Fig 1A</a>.…”

DataSheet1_Long-Term Variation in Wintertime Atmospheric Diffusion Conditions Over the Sichuan Basin.docx by Guoyin Wang (10939987)

“…Both V_E and ASI reveal a decrease tendency of atmospheric diffusion condition from the northwestern portion of the basin to the southeast. …”

Regional burden, trends, and future projections of chronic kidney disease due to type 2 diabetes mellitus in South Asia: insights from the global burden of disease study (1990–2021... by Lovely Jain (21260188)

“…</p> <p>From 1990 to 2021, prevalence decreased slightly (e.g. India: 5.4% to 5.2%), while mortality increased (e.g.Pakistan: 33.7 to 42.1 per 100,000). …”

Mast cell density and ano-genital sensitivity following therapeutic imatinib treatment in ND4 female mice previously exposed to MI. by Jaclyn M. Kline (9565161)

“…<p>(A-B) Representative images of labiar tissue collected from MI-challenged mice 1 day after 6 daily therapeutic imatinib treatments or NT shown at 200× magnification. …”

Image_1_Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-κB Signaling in Diab... by Chenyue Liu (5936954)

“…In addition, femoral strength was detected by a three-point bending assay, bone microstructure was detected with micro-computer tomography. …”

Distinct CLP migratory groups persist under low serum conditions. by Joël Beyeler (652358)

“…<p>The graphs show the RWC in scratch wound assays at 24 h in 0.3% FCS/DMEM (*p<0.05, **p<0.01, ***p<0.001). (A) Despite a general decrease of the RWC, “fast” and “intermediate” CLP groups could still be distinguished under low-serum conditions. …”

Fig 4 - by Richard D. Lange (11768146)

“…This is analogous to, for example, an orientation-discrimination task with randomized phases, such that the <i>average</i> stimulus in pixel-space is identical for both categories. While panel (v) (precise model) shows a slight increase in variance in the dp_b(<b>x</b>|…)/d<i>s</i> direction, consistent with (f) and (k), panel (q) (imprecise model) shows a slight <i>decrease</i>.…”

Data_Sheet_1_Little Impact of NaCl Reduction in Swiss-Type Cheese.docx by Valérie Gagnaire (783586)

“…Casein hydrolysis in vitro was similar or higher at pH 5.2, i.e., cheese pH, compared to pH 7.5, and slightly decreased at the highest salt concentrations (3.0 and 4.4%). …”