Energetics of Ionized Water Molecules in the H‑Bond Network near the Ca²⁺ and Cl^– Binding Sites in Photosystem II by Keisuke Saito (516747)

“…It seems likely that Ca²⁺ plays a role in not only (i) maintaining the H-bond network and facilitating TyrZ oxidation [tuning <i>E</i>_m(TyrZ)] but also (ii) providing the valence of +2, decreasing the p<i>K</i>_a of the ligand molecule (W1), and facilitating the release of the proton from W1 in the S₂ to S₃ transition together with Cl^–.…”

Presentation 1_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhi... by Gyeong Ho Baek (21382907)

“…Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …”

Presentation 3_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhi... by Gyeong Ho Baek (21382907)

“…Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …”

Data Sheet 1_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhibi... by Gyeong Ho Baek (21382907)

“…Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …”

Data Sheet 2_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhibi... by Gyeong Ho Baek (21382907)

“…Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …”

Presentation 2_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhi... by Gyeong Ho Baek (21382907)

“…Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …”

sAxl levels in relation to treatment outcomes. by Ioannis Parodis (2851211)

New [ONOO]-Type Amine Bis(phenolate) Ytterbium(II) and -(III) Complexes: Synthesis, Structure, and Catalysis for Highly Heteroselective Polymerization of <i>rac</i>-Lactide by Sheng Yang (592249)

“…Complex <b>5</b> is a THF-solvated monomer. Each six-coordinated Yb^III ion in both complexes adopts a distorted octahedron. …”

Molecular interactions of agonist and inverse agonist ligands at serotonin 5-HT_2C G protein-coupled receptors: computational ligand docking and molecular dynamics studie... by Tania C. Córdova-Sintjago (597380)

“…<div><p>To understand molecular determinants for ligand activation of the serotonin 5-HT_2C G protein-coupled receptor (GPCR), a drug target for obesity and neuropsychiatric disorders, a 5-HT_2C homology model was built according to an adrenergic β₂ GPCR (β₂AR) structure and validated using a 5-HT_2B GPCR crystal structure. …”

The α7 nAChR directly attenuates in EB3 entry into the growth cone. by Justin R. King (793933)

Serum Axl predicts histology-based response to induction therapy and long-term renal outcome in lupus nephritis by Ioannis Parodis (2851211)

“…Baseline sAxl levels decreased in CRs (<i>P</i> = 0.002) and HRs (<i>P</i><0.001), but not in non-responders; levels ≥36.6 ng/mL yielded a >5 times higher probability of histology-based response (odds ratio, OR: 5.5; 95% confidence interval, CI: 1.2–25.1). …”

Differentially Expressed Gene Transcripts Using RNA Sequencing from the Blood of Immunosuppressed Kidney Allograft Recipients by Casey Dorr (735702)

“…Principal components (PCs) were computed using a surrogate variable approach. DEGs post-transplant were identified by controlling false discovery rate (FDR) at < 0.01 with at least a 2 fold change in expression from pre-transplant. …”

Distribution of Total and Active RNA Polymerase II at Genes During the Transition from G1 to G2. by Douglas Maya-Miles (7024967)

Numerical evaluation of the thermal performance of a near-surface earth-to-air heat exchanger with short-grass ground cover: A parametric study by Pakari, Ali

“…By increasing the soil thermal conductivity from 1 to 5 W m−1 K−1 the outlet temperature decreased by about 4.4 °C.…”
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A degradation debt? Large-scale shifts in community composition and loss of biomass in a tropical forest fragment after 40 years of isolation by Rakan A. Zahawi (530432)

“…Turnover was high: 22.9% of stems in the first survey were lost, and 27.8% of stems in the second survey represented new recruits. Mean tree diameter decreased significantly and there was a 10% decrease in overall biomass. …”

Impact of introducing fluorescent microscopy on hospital tuberculosis control: A before-after study at a high caseload medical center in Taiwan by Hsin-Yun Sun (61134)

“…</p><p>Results</p><p>After switch to fluorescence microscopy, median non-isolated infectious duration decreased from 12.5 days to 3 days (P<0.001). Compared with conventional microscopy, fluorescence microscopy increased sputum smear detection rate by two-fold (for all patients: from 22.8% to 48.1%, P<0.001; for patients with cavitary lung lesion: from 43% to 82%, P = 0.029) and was associated with a 2-fold higher likelihood of prompt respiratory isolation (odds ratio mediated by the increase in sputum smear detection rate: 1.8, 95% CI 1.3–2.5). …”

Altered Serum MicroRNAs as Novel Diagnostic Biomarkers for Atypical Coronary Artery Disease by Jun Wang (5906)

“…</p><p>Results</p><p>The TaqMan low density array and RT-qPCR analysis identified four serum miRNAs including miR-487a, miR-502, miR-208 and miR-215 that were significantly increased, while one miRNA, miR-29b, that was significantly decreased in ACAD patients compared with normal controls (<i>P</i><0.05). …”

Data_Sheet_1_An Upstream Open Reading Frame Represses Translation of Chicken PPARγ Transcript Variant 1.PDF by Yankai Chu (8503011)

“…Bioinformatics analysis showed that chicken PPARγ transcript 1 (PPARγ1) possessed an upstream open reading frame (uORF) in its 5′ UTR. Mutation analysis showed that a mutation in the uORF led to increased Renilla luciferase activity and PPARγ protein expression, but decreased Renilla luciferase and PPARγ1 mRNA expression. mRNA stability analysis using real-time RT-PCR showed that the uORF mutation did not interfere with mRNA stability, but promoter activity analysis of the cloned 5′ UTR showed that the uORF mutation reduced promoter activity. …”

Supplementary file 1_A risk prediction model of spontaneous miscarriage in women with threatened miscarriage: a prospective cohort study.docx by Chee Wai Ku (5722886)

“…Introduction<p>This study aims to develop a holistic risk prediction triage tool for women with threatened miscarriage by integrating clinical, biochemical, and radiological factors. …”

Involvement of mitochondrial pathway in AG–4 induced apoptosis. by Deepak Kumar (63095)

“…<p>(A) Loss of mitochondrial membrane potential. Cells were incubated with AG–4 (5.4 μM, 0–48 h) and loaded with JC–1 for flow cytometric analysis of mitochondria transmembrane potential. …”