Potential interplay between Aβ oligomers, Ca²⁺, and a target cell in the initial stages of Alzheimer's disease. by Anna Itkin (354170)

“…These three steps might form an inimical cycle leading to increases in both cytosolic calcium and Aβ oligomer concentrations. (4) Aβ oligomers disrupt intracellular membranes, leading to apoptosis <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018250#pone.0018250-Kawahara1" target="_blank">[34]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018250#pone.0018250-Arispe1" target="_blank">[41]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018250#pone.0018250-Arispe2" target="_blank">[64]</a>. (5) Extracellular calcium concentration ([Ca²⁺]_e) promotes oligomerization of extracellular Aβ. (6) Oligomers form nonspecific pores in the plasma membrane, disturbing cellular integrity and leading to apoptosis <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018250#pone.0018250-Bucciantini1" target="_blank">[65]</a>. (7) Aβ oligomers can interact and impair calcium channels at the membrane surface, opening calcium importers and blocking calcium exporters such as the voltage-dependent calcium channel <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018250#pone.0018250-Rovira1" target="_blank">[66]</a>. …”

Antifatigue Effects of <i>Panax ginseng</i> C.A. Meyer: A Randomised, Double-Blind, Placebo-Controlled Trial by Hyeong-Geug Kim (403328)

“…<div><p></p><p>The present study investigated the antifatigue effects of <i>Panax ginseng</i> C.A. Meyer in 90 subjects (21 men and 69 women) with idiopathic chronic fatigue (ICF) in a randomised, double-blind, placebo-controlled and parallel designed trial. …”

Maps depicting the study site. by Matthew S. Mills (3957410)

A hierarchical organization of yeast kinases by their impact. by Ilan Smoly (3704866)

“…<p>A. A layered architecture of kinases by their impact on the phosphorylation of each other. …”

<i>T</i>_<i>2</i> relaxation time measurements in various muscle regions of control (Ctr) and <i>lepb</i>-deficient (<i>lepb</i>^<i>-/-</i>) adult zebrafish. by Muhamed N. Hashem Eeza (15295543)

S1 Data - by Xiaochun Zhao (448387)

“…Furthermore, the distribution pattern shifted from a dispersed, point-like distribution to an aggregated and continuous distribution. …”

Representative case showing topographic change after epiretinal membrane (ERM) removal. by Seung Min Lee (1644409)

“…The FD decreased after surgery. Three points of vessels crossing the disc rim (white arrows) were marked to superimpose the baseline and follow-up fundus photographs. …”

The Sleeping Beauty: How Reproductive Diapause Affects Hormone Signaling, Metabolism, Immune Response and Somatic Maintenance in <i>Drosophila melanogaster</i> by Olga I. Kubrak (659970)

“…<div><p>Some organisms can adapt to seasonal and other environmental challenges by entering a state of dormancy, diapause. Thus, insects exposed to decreased temperature and short photoperiod enter a state of arrested development, lowered metabolism, and increased stress resistance. …”

Model of the consequences of Ctu1 deficiency in zebrafish, figured by Figdraw. by Yangziwei Yu (20460661)

“…<p>Recently, the essential role of mcm⁵s²U₃₄ tRNA modification and their modifying enzymes in proliferation and development has been demonstrated from yeast to mammals [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0315854#pone.0315854.ref007" target="_blank">7</a>]. …”

Saccadic timing neurons. by Jordan Barnes (12256947)

Evaluation of Microflow Digital Imaging Particle Analysis for Sub-Visible Particles Formulated with an Opaque Vaccine Adjuvant by Grant E. Frahm (641684)

“…Reduced edge gradients and a decrease in measured particle sizes were noted as adjuvant concentrations increased. …”

Supplementary Material for: Effect of Enteral Vitamin A on Fecal Calprotectin in Extremely Preterm Infants: A Nested Prospective Observational Study by Rakshasbhuvankar A.A. (8503653)

“…We aimed to assess whether enteral water-soluble vitamin A supplementation in extremely preterm infants decreases fecal calprotectin, a marker of intestinal inflammation. …”

Excel spreadsheets of raw data. by Tasmin L. Rymer (12135918)

“…We collected faecal samples during an undiagnosed illness outbreak in a captive colony of animals, and again at least one year later, and quantified the microbiome at each time point using 16s ribosomal rRNA gene sequencing. …”

Prevalence as a function of the genotype network characteristics. by Oliver M. Cliff (9585550)

“…<p>Each point represents a node (MLVA profile), with the y-axis as the average prevalence of that profile’s undirected cluster. …”

<em>Cdh11</em> Acts as a Tumor Suppressor in a Murine Retinoblastoma Model by Facilitating Tumor Cell Death by Mellone N. Marchong (249928)

“…In tumors of <em>Cdh11-</em>null mice, cell death was decreased 5- to 10-fold (p<0.03 for all markers), while proliferation <em>in vivo</em> remained unaffected (p = 0.121). …”

IS-Linked Movement of a Restriction-Modification System by Noriko Takahashi (231617)

“…<div><p>Potential mobility of restriction-modification systems has been suggested by evolutionary/bioinformatic analysis of prokaryotic genomes. Here we demonstrate in vivo movement of a restriction-modification system within a genome under a laboratory condition. …”

Primers used in present study. by Razia Liaqat (17873634)

“…Fish (n = 260; initial weight = 10.00 ± 1.00 g) were fed eight isonitrogenous (30%) diets, each containing different combinations of tryptophan (Trp), methionine (Met), and lysine (Lys) (A0: no amino acids, A1: Trp, A2: Lys, A3: Met, A4: Trp + Met, A5: Lys + Trp, A6: Met + Lys, A7: Lys + Trp + Met, 6 g/kg each) for 10 weeks. …”

Developing a protocol for a preventive oral health exam for elderly people (EDePAM) using E-Delphi methodology by Alicia MORALES (12806784)

How Water Regulates Nonradiative Deactivation of DNA-Templated Green-Yellow Rod-Shaped Silver Clusters by Ruslan R. Ramazanov (3830713)

“…The rational design of imaging probes based on DNA-stabilized silver clusters focuses on the key structural factors that affect fluorescence efficiency. We theoretically examined structural features determining nonradiative deactivation of five green or yellow-emitting fluorophores based on oligonucleotide-stabilized rod-shaped silver clusters. …”

How Water Regulates Nonradiative Deactivation of DNA-Templated Green-Yellow Rod-Shaped Silver Clusters by Ruslan R. Ramazanov (3830713)

“…The rational design of imaging probes based on DNA-stabilized silver clusters focuses on the key structural factors that affect fluorescence efficiency. We theoretically examined structural features determining nonradiative deactivation of five green or yellow-emitting fluorophores based on oligonucleotide-stabilized rod-shaped silver clusters. …”