Telomerase Variant A279T Induces Telomere Dysfunction and Inhibits Non-Canonical Telomerase Activity in Esophageal Carcinomas by Yuwei Zhang (388956)

“…The minor allele frequency of the A279T variant was five-fold higher in EsC patients compared to healthy blood donors (p<0.01). …”

HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells by Tessa D. Nauta (3142845)

“…Silencing of HIF-2α with si-RNA partially restored the inhibition of endothelial sprouting pointing to a HIF-2α-dependent mechanism. In addition, reduction of uPA contributed to reduced endothelial tube formation in a fibrin matrix during prolonged hypoxia.…”

Pyrazole-Infused Metal Complexes: Anticancer Activity, DNA Cleavage, and Biophysical Insights into DNA/BSA Interactions by Tankadhar Behera (22267115)

“…A pyrazole-based ligand bearing dimethyl substituents was used in the synthesis of Co(II), Cu(II), and Zn(II) complexes, specifically [CoCl₂(dmp)₂] (<b>1</b>), [CuCl₂(dmp)₂]₂ (<b>2</b>), and [ZnCl₂(dmp)₂] (<b>3</b>), where dmp = 3,5-dimethylpyrazole. …”

Inhibition of glycolysis inhibits replication of SVA. by Huizi Li (6241586)

Is There a Classical Nonsense-Mediated Decay Pathway in Trypanosomes? by Praveen Delhi (204401)

“…In contrast, inhibition of translation, either using 5′-secondary structures or by lengthening the 5′-untranslated region, usually decreased reporter mRNA abundance. …”

Monthly mean (±SE) soil temperatures at the surface (5 cm) and at depth (100 cm) for unburned (solid line) and burned (dotted line) sites by landscape type from September 2011 to A... by Dana R Nossov (557153)

“…On average, fire caused a five-fold decrease in mean surface organic layer thickness, a doubling of water storage in the active layer, a doubling of thaw depth, an increase in soil temperature at the surface (−0.6 to +2.1 ° C) and at 1 m depth (−1.7 to +0.4 ° C), and a two-fold increase in net soil heat input. …”

Supplementary Figures 1-9 from Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline by Bridget A. Quinn (14917745)

“…(S1) Sabutoclax causes a G1-S phase cell cycle arrest. (S2) Pancreatic cancer cells exhibit varying levels of sensitivity to Minocycline. …”

A case with Chiari malformation 2 diagnosed with vertigo by Zeynep Özözen Ayas (6840431)

“…Symptoms occurs as a results of pressure on the cerebellum like as vertigo, ataxia, vision problems, headache. …”

Image_2_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Image_3_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Image_6_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Image_1_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

DataSheet_1_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.xls by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

DataSheet_2_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.xls by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Image_4_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Table_1_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.xls by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Experimental and Theoretical Studies on the Platinum-Mediated Selective C(sp)–Si Bond Cleavage of Alkynylsilanes by Yasuhiro Okuda (1591588)

“…In comparison, Hammett plots show that C­(sp)–Si bond cleavage rates are accelerated by electron-rich alkynylsilanes, which is opposite to the ordinary oxidative addition of aryl halides to transition metals often observed in catalytic cross-coupling reactions. A DFT calculation reveals that intermediates and transition states are stabilized by electron-rich alkynylsilanes and that the five-membered hemilabile P–N ligand is essential, in which a reactive electron-deficient 14-electron platinum(0) species is produced via the dissociation of nitrogen, giving rise to a monodentate phosphine coordination. …”

Typical fit of a Ti Kβ spectrum by C T Chantler (557430)

“…The peak energy of the titanium Kβ spectral profile is found to be 4931.966 ± 0.022 eV prior to instrumental broadening. This 4.5 ppm result decreases the uncertainty over the past literature by a factor of 2.6 and is 2.4 standard deviations from the previous standard. …”

Parametric analysis of evoking KCs by directly versus indirectly depolarizing RE. by Rachel A. Mak-McCully (634502)

“…Percent change was calculated for spindling power and firing. The average of five runs at a particular stimulation value and time point is plotted ± SEM. …”

Phenotypes of the shACADS and shNTC knockdown Huh7 cells. by Kerstin Matejka (6729155)

“…<p>Doxycycline-induced knockdown of ACADS resulted in a long-term decrease of protein abundance and mRNA expression, and an intracellular accumulation of C4-acylcarnitine, which reflects the ACADS substrate C4-CoA. …”