DNA methylation associates with altered mRNA expression of key genes involved in NASH pathogenesis. by Sophie Grapentine (11794547)

“…(C) RT-PCR analysis of insulin, MAPK and JAK/STAT signalling pathways in 8-month-old <i>Pcyt2</i>^{<i> + /-</i>} mice shows altered DNA methylation influences the expression of genes within key pathways relevant to NASH pathogenesis. Genes that have a methylation increased or decreased of infinity are represented as Log2FC = 5.…”

Supplementary Material for: Demethylzeylasteral (T-96) Alleviates Allergic Asthma via Inhibiting MAPK/ERK and NF-κB Pathway by Huang J. (3231918)

“…Also, enhanced inflammatory infiltration and mucus hypersecretion were ameliorated in lungs of asthmatic mice following increasing doses of T-96 treatment, accompanied by decreased eosinophils in bronchoalveolar lavage fluid (BALF), IgE and OVA specific-IgE levels in serum and downregulated IL-5 and IL-13 expressions in BALF and lung tissues as well. …”

Table_1_Contributions of Individual, Family, and School Characteristics to Chilean Students’ Social Well-Being at School.DOCX by Verónica López (293471)

“…This study analyzed these joint contributions in a nationally representative sample of 6,389 children and adolescents enrolled in 5th–11th grades. …”

Image_1_The Impact of Body Mass Index Upon the Efficacy of Adalimumab in Hidradenitis Suppurativa.pdf by John W. Frew (7401773)

“…Descriptive, multivariable regression analysis and receiver operating characteristic (ROC) curves were calculated to assess the relationship between BMI and clinical outcome measures using R v3.5.3. Participants in the overweight and obese BMI category had reduced odds (58 and 67%, respectively) of achieving HiSCR [OR = 0.42 (95%CI −0.19, 0.91) p = 0.03], [OR = 0.33 (95%CI 0.16, 0.67) p = 0.002] compared to participants with BMI < 25. …”

Table_1_Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review.DOCX by James Jiqi Wang (11736326)

“…Chlorpromazine (25 or 50 mg) was injected intramuscularly, followed by continuous intravenous infusion (2–8 mg/h). The patients' BP decreased to 100–150/60–100 mmHg within 1–3 h and stabilized within 3–5 days. …”

Bone marrow stromal cell antigen 2(BST2) suppresses the migration and invasion of trophoblasts in preeclampsia by downregulating matrix metallopeptidase 2(MMP2) by Liu Jinyu (10938528)

“…<p>Preeclampsia is a grievous pregnancy-related complication with an incidence of approximately 5∼7% in pregnant women. …”

Model validation: autophagy inducers reduce TAU hyperphosphorylation and aggregation in TAU-P301L neurons. by An Verheyen (840523)

“…<b>(G, H)</b> AlphaLISA results reveal that trehalose significantly reduces hTAU10 (P<0,001) and AT8 TAU aggregation levels <i>versus</i> control (P = 0,006 at 31,5 mM and P = 0,014 at 125 mM). <b>(I, J)</b> Only at 125 mM of trehalose, both phosphorylated TAU (P<0,001, I) and total TAU levels (P<0,001, J) are decreased. …”

Inhibiting Spinal Neuron-Astrocytic Activation Correlates with Synergistic Analgesia of Dexmedetomidine and Ropivacaine by Huang-Hui Wu (541091)

“…</p><p>Results</p><p>i.t. Dex or Ropi displayed a short-term analgesia in a dose-dependent manner, and consecutive daily administrations of their combination showed synergistic analgesia and remarkably down-regulated neuronal and astrocytic activations indicated by decreases in the number of Fos-ir neurons and the GFAP expression within the SDH, respectively.…”

Effect of everolimus on precursor cell proliferation <i>in vivo</i> and <i>in vitro.</i> by Martine Dubois (257561)

“…The increase of neurosphere mean volume might be explained by an increased proportion of bigger neurospheres and a decreased proportion of smaller neurospheres associated with everolimus treatment.…”

Table_3_Physiological and molecular mechanisms of the response of roots of Pinus massoniana Lamb. to low-temperature stress.doc by Jingyu Lu (621174)

“…BAM, 4CL, CCoAOMT, PRX5, WRKYs, and hormone synthesis related genes play important roles. …”

FTI-277 treatment reversed burn-induced impaired insulin receptor (IR)-insulin receptor substrate-1 (IRS-1) signaling in skeletal muscle. by Harumasa Nakazawa (684211)

“…Insulin significantly increased p-IRS-1/GAPDH ratio and p-IRS-1/IRS-1 ratio in sham-burned mice and FTI-277-treated burned mice, whereas insulin failed to significantly increase p-IRS-1/GAPDH ratio or p-IRS-1/IRS-1 ratio in vehicle-treated burned mice (F, G). There was a trend of increase in insulin-stimulated p-IRS-1/IRS-1 ratio in vehicle-treated burned mice, but there was no statistical difference (G). n = 5 mice per group for saline-injected mice, n = 6 mice per group for insulin-injected sham-burned mice, n = 8 mice per group for insulin-injected burned mice. …”

Results from the virtual experiment using the diffusion model. by Honghan Li (19332798)

“…(B) Relationship between distance from the geometrically constrained edge <i>r</i>* and probability of generating SFs <i>P</i>_<i>mean</i> for three cases of aspect ratio (<i>AR</i> = 1, 3 and 5). (C,D) Probability distribution function (PDF) of the probability of generating SFs <i>P</i> with a constraint of (C) <i>AR</i> = 1 and (D) <i>AR</i> = 3. …”

Mechanisms mediating risk for HIV acquisition and transmission in menopausal women. by Kerry Murphy (724422)

“…During menopause there is a loss of epithelial barrier integrity (1) and increase in BV associated species including <i>Atopobium</i>, <i>Prevotella</i>, and <i>Gardnerella</i> (2), which influence release of proinflammatory cytokines e.g. …”

Long-term effects of neonatal malnutrition on microbicide response, production of cytokines, and survival of macrophages infected by Staphylococcus aureus sensitive/resistant to me... by Natália Gomes de Morais (10470273)

“…The plates were incubated in a humid atmosphere at 37 degrees Celsius containing 5% CO2 for 24 hours. …”

Image_1_Physiological and molecular mechanisms of the response of roots of Pinus massoniana Lamb. to low-temperature stress.png by Jingyu Lu (621174)

“…BAM, 4CL, CCoAOMT, PRX5, WRKYs, and hormone synthesis related genes play important roles. …”

IL-6 increases Oct-4 and telomerase expression in KPCs and SKPs. by Qunzhou Zhang (257627)

“…The results are representative of at least five independent experiments using KPCs and the matched SKPs from different patient donors (n = 5).…”

Data Sheet 1_Supply chain integration, strategic choice and corporate growth of agricultural companies: an analysis of dynamic QCA.csv by Xiaonan Fan (5743178)

“…At the strategy level, entrepreneurial orientation is crucial for the corporate growth. (5) There is a substitution relationship between the factors. …”

Effect of dihydroferulic acid obtained from fermented rice bran extract on neuroprotection and behavioral recovery in an ischemic rat model by Sang Hyun LEE (5160065)

“…In vivo dFA administration exerted a neuroprotective effect by reducing the infarct volume and enhancing behavioral function following cerebral ischemia. dFA treatment protected neuronal cells from ischemic injury and increased the transcription levels of anti-oxidant genes (PDI and Nrf2) and neurotrophic factors (BDNF and NGF). dFA treatment decreased the expression of Iba-1 and MFG-E8 genes, which signal neural cell death.…”

Supplemental Figure 1-8 from Dual HDAC and PI3K Inhibitor CUDC-907 Downregulates MYC and Suppresses Growth of MYC-dependent Cancers by Kaiming Sun (15069697)

“…CUDC-907 does not induce significant body weight loss or obvious toxicity in human DLBCL cell line-derived xenograft models or Eμ-Myc transgenic tumor mouse syngeneic models of B-cell lymphoma; Supplemental Figure S5. CUDC-907 decreases MYC protein levels in cell line-derived Burkitt lymphoma xenograft tumors; Supplemental Figure S6. …”

STC in the bladder leads to increased expression of YAP/WWTR1 target genes. by Karen J. Aitken (16679497)

“…<p><b>A:</b> Pan-<i>BDNF</i> at 1 and 7 weeks augmented significantly with STC, but not incision at 1week. …”