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67441
Data_Sheet_1_Health-related heterogeneity in brain aging and associations with longitudinal change in cognitive function.docx
Published 2023“…Among resilient brain agers, class 1 was associated with a decrease in cognition, and class 2 with an increase over 5 years, though was a small effect that was equivalent to a 0.04 standard deviation difference per year. …”
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67442
PI3K/AKT signaling pathway is essential for survival of induced pluripotent stem cells
Published 2016“…However, there is only poor insight into iPSCs cell signaling as the regulation of apoptosis. In this study, we focused our attention on the apoptotic response of Alzheimer fibroblast-derived iPSCs and two other Alzheimer free iPSCs to five biologically relevant kinase inhibitors as well as to the death ligand TRAIL. …”
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67443
Loss of <i>bmm</i> in the neurons with an independent RNAi line has no effect on triglyceride storage or breakdown in females.
Published 2021“…(F) Triglyceride breakdown post-starvation was modestly decreased by a similar magnitude among genotypes in 5-day-old virgin <i>nSyb>UAS-bmm-RNAi</i> females and control females (<i>nSyb>+</i> and <i>+>UAS-bmm-RNAi</i>) between 0 and 12 hours STV (<i>p</i> = 0.21, 0.017, and 0.43, respectively; one-way ANOVA followed by Tukey HSD test). …”
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67444
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67445
The Effect of Vaccination on the Evolution and Population Dynamics of Avian Paramyxovirus-1
Published 2010“…Vaccines derived from avirulent genotype II strains were developed in the 1950s and are in use globally, whereas Australian strains belonging to genotype I were developed as vaccines in the 1970s and are used mainly in Asia. In this study, we evaluated the consequences of attenuated live virus vaccination on the evolution of aPMV-1 genotypes. …”
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67446
Image_1_Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic...
Published 2024“…Regarding the pathway of negative regulation of immune response, we found a significant decrease in the cell surface expression of CD86, HLA-DR, and PD-L1 upon stimulation with 1 µM Al-CPI.…”
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67447
Image_2_Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic...
Published 2024“…Regarding the pathway of negative regulation of immune response, we found a significant decrease in the cell surface expression of CD86, HLA-DR, and PD-L1 upon stimulation with 1 µM Al-CPI.…”
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67448
Image_3_Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic...
Published 2024“…Regarding the pathway of negative regulation of immune response, we found a significant decrease in the cell surface expression of CD86, HLA-DR, and PD-L1 upon stimulation with 1 µM Al-CPI.…”
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67449
Transcript levels of dsRNA-treated sporocysts 7 days after dsRNA exposure.
Published 2009“…Colored bars represent sporocyst mRNA levels showing consistent and statistically significant decrease (dsRNA-Smad4/GFP, <i>P</i> = 0.0056; -lactate dehydrogenase/GFP, <i>P</i> = 0.0358; -Cav2A/GFP, <i>P</i> = 0.0136; -EF1α/GFP, <i>P</i> = 0.0358; -calcineurin B/GFP, <i>P</i> = 0.0189; -GST26/GFP, <i>P</i> = 0.0136; -SmZF1/GFP, <i>P</i> = 0.0189; -fibrillarin/GFP, <i>P</i> = 0.0407; -GST28/GFP, <i>P</i> = 0.0284; -GPx/GFP, <i>P</i> = 0.0269 and -TPx1/GFP, <i>P</i> = 0.0358/-TPx2/GFP, <i>P</i> = 0.0358) or increase (dsRNA-SOD/GFP, <i>P</i> = 0.0294) in target transcript levels when compared to the GFP-dsRNA control treatment. …”
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67450
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67451
<i>In vitro</i> and <i>in vivo</i> genotoxic effects of straight versus tangled multi-walled carbon nanotubes
Published 2016“…No systemic genotoxic effects, assessed by the γ-H2AX assay in blood mononuclear leukocytes or by micronucleated polychromatic erythrocytes (MNPCEs) in bone marrow or blood, were observed for MWCNT-S by either exposure technique. MWCNT-T showed a dose-related <i>decrease</i> in DNA damage in BAL and lung cells of mice after a single pharyngeal aspiration (1–200 μg/mouse) and in MNPCEs after inhalation exposure (17.5 mg/m<sup>3</sup>). …”
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67452
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67453
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67454
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67455
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67456
Computational Study on the Origin of the Stereoselectivity for the Photochemical Denitrogenation of Diazabicycloheptene
Published 2003“…The origin of the inversion stereoselectivity of housane formation via <i>photochemical</i> nitrogen extrusion of diazabicycloheptene (<b>DBH</b>) has been investigated using reaction path computations and multireference second-order perturbation theory within a CASPT2//CASSCF scheme. We show that the primary photoproduct of the reaction is an <i>exo-axial </i>conformer of the diazenyl diradical (<b><sup>1</sup></b><sup></sup><b>DZ</b>) which displays a cyclopenta-1,3-diyl moiety with a <i>Cs</i>-like structure. …”
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67457
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67458
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67459
Computational Study on the Origin of the Stereoselectivity for the Photochemical Denitrogenation of Diazabicycloheptene
Published 2003“…The origin of the inversion stereoselectivity of housane formation via <i>photochemical</i> nitrogen extrusion of diazabicycloheptene (<b>DBH</b>) has been investigated using reaction path computations and multireference second-order perturbation theory within a CASPT2//CASSCF scheme. We show that the primary photoproduct of the reaction is an <i>exo-axial </i>conformer of the diazenyl diradical (<b><sup>1</sup></b><sup></sup><b>DZ</b>) which displays a cyclopenta-1,3-diyl moiety with a <i>Cs</i>-like structure. …”
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67460