Bringing Down Cancer Aircraft: Searching for Essential Hypomutated Proteins in Skin Melanoma by Mikhail Pyatnitskiy (507839)

“…<div><p>We propose an approach to detection of essential genes/proteins required for cancer cell survival. A gene is considered essential if a mutation with high impact upon the function of encoded protein causes death of the cancer cell. …”

Percept dominance durations as a function of differential dot luminance. by P. Christiaan Klink (180011)

“…A decrease of the dot luminance of one of the layers of a balanced high luminance stimulus does not decrease the durations of the episodes when this layer is perceived in the foreground. …”

Standardization of A Physiologic Hypoparathyroidism Animal Model by Soo Yeon Jung (3190083)

“…These findings demonstrate that PTX animal models produced by using the fluorescent-identification method, and fed a 0.5% calcium diet, are appropriate for hypoparathyroidism treatment studies.…”

Overexpression of miR-184 disrupts pleated septate junctions in peripheral nerves. by Sravya Paluri (5475260)

Results of the quantitative content validity. by Zahra Moradi Rekabdar Kalaiee (18823899)

“…</p><p>Results</p><p>The results showed that out of the 86 participating patients, 52 (60.5%) were male and 34 (39.5%), with a mean (Standard Deviation) of 39.14 (10.89) years old. …”

Phase transition as a function of fascin concentration. by Yaron Ideses (270357)

“…Above a certain fascin concentration of 0.5 µM (g) the size and the number of stars decreases; the stars coexist with an entangled network of actin/fascin bundles, seen in the image background. …”

Imido Titanium Ethylene Polymerization Catalysts Containing Triazacyclic Ligands by Nico Adams (342780)

“…The use of MAO pretreated with BHT-H (BHT-H = 2,6-di-<i>tert</i>-butyl-4-methylphenol) led to higher productivites, increased polymer molecular weights, and more polymer chain unsaturations, but productivity decreased when a large excess of BHT-H was used. The reactions of the well-defined alkyl species Ti(N^tBu)(Me₃[9]aneN₃)Me₂, [Ti(N^tBu)(Me₃[9]aneN₃)(μ-Me)₂AlMe₂]⁺, and [Ti(N^tBu)(Me₃[9]aneN₃)Me]⁺ with BHT-H were examined, and the aryloxide compound [Ti(N^tBu)(Me₃[9]aneN₃)(BHT)][BAr^F₄] was isolated (Ar^F = C₆F₅). …”

IgG1 as a Potential Biomarker of Post-chemotherapeutic Relapse in Visceral Leishmaniasis, and Adaptation to a Rapid Diagnostic Test by Tapan Bhattacharyya (172083)

“…<div><p>Background</p><p>Visceral leishmaniasis (VL), caused by protozoa of the <i>Leishmania donovani</i> complex, is a widespread parasitic disease of great public health importance; without effective chemotherapy symptomatic VL is usually fatal. …”

VPS34 inhibition depletes intracellular iron by blocking iron uptake through enhanced degradation of TFR and excess iron rescues the growth defect in RKO cells. by Marek J. Kobylarz (9292599)

“…Oligomycin (Oligo) inhibits ATP synthase (Complex V) and decreases OCR; FCCP uncouples oxidative phosphorylation and increases OCR; and rotenone/antimycin A (ROT & AA) inhibits Complex I and III, respectively and decreases OCR. …”

Note: Cytonuclear patterns of a honey bee population from the Azores show a stable population at the nuclear but not at the mitochondrial DNA level by Dora Henriques (721562)

“…While the C-lineage contribution has remained stable at the nuclear level for over 20 years, there has been a recent decrease in the proportion of C-derived mitotypes.…”

Adult fat body precursors spread from the ventral midline. by Yuting Lei (9624598)

Table_1_Prediction of prognosis in patients with nontraumatic intracranial hemorrhage using blood urea nitrogen-to-creatinine ratio on admission: a retrospective cohort study based... by Peng Chen (6514)

“…On the left side of the inflection point, the 30-day and 1-year mortality rate decreased by 17.7% (OR = 0.823, 95%CI: 0.705–0.960; p = 0.013) and 5.3% (OR = 0.947, 95%CI: 0.899–0.999; p = 0.046), respectively, per 1 unit increment of BUNCR. …”

DataSheet_1_The contribution of a novel PHEX gene mutation to X-linked hypophosphatemic rickets: a case report and an analysis of the gene mutation dosage effect in a rat model.pdf by Xiaoming Chen (230202)

“…The CRISPR/Cas9 gene editing technology was employed to construct the rat model with the PHEX gene mutation (c.1985delA). Through reproductive procedures, five genotypes of rats were obtained: female wild type (X/X), female heterozygous (-/X), female homozygous wild type (-/-), male wild type (X/Y), and male hemizygous (-/Y). …”

DataSheet_2_The contribution of a novel PHEX gene mutation to X-linked hypophosphatemic rickets: a case report and an analysis of the gene mutation dosage effect in a rat model.doc... by Xiaoming Chen (230202)

“…The CRISPR/Cas9 gene editing technology was employed to construct the rat model with the PHEX gene mutation (c.1985delA). Through reproductive procedures, five genotypes of rats were obtained: female wild type (X/X), female heterozygous (-/X), female homozygous wild type (-/-), male wild type (X/Y), and male hemizygous (-/Y). …”

Loss of cilia results in aberrant production of GLI3 and GLI2 isoforms in the FNP. by Ching-Fang Chang (3325185)

“…<p>(A) Western blot analysis of GLI3FL, GLI3R, GLI2FL and GLI2R from the FNP of e11.5 embryos (inset schematic, FNP indicated in red). …”

Fundamental Studies and Development of Nickel-Catalyzed Trifluoromethylthiolation of Aryl Chlorides: Active Catalytic Species and Key Roles of Ligand and Traceless MeCN Additive Re... by Guoyin Yin (1629022)

“…It relies on a relatively inexpensive Ni­(cod)₂/dppf (cod = 1,5-cyclooctadiene; dppf = 1,1′-bis­(diphenylphosphino)­ferrocene) catalyst system and the readily accessible coupling reagent (Me₄N)­SCF₃. …”

Fig 6 - by Mostafa Khaledi (9706915)

“…<p>(a) Skin. Mouse in the G5 group (betamethasone) (H&E) (Bar = 20–100 μm). …”

Effect of equalizing the resting cost on the information-metabolic efficiency. by Tomas Barta (8067509)

“…<b>A</b>: The same contour plot as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011896#pcbi.1011896.g005" target="_blank">Fig 5B</a>. …”

Influence of model parameters on modeling thresholds. A by Sébastien Joucla (312219)

“…Finally, increasing or decreasing the maximum sodium conductance by a factor of 2 only altered the amplitude of the TCs by a factor comprised between −27.5% and +40% (C2). …”

Data_Sheet_1_Moderate increase of serum uric acid within a normal range is associated with improved cognitive function in a non-normotensive population: A nationally representative... by Jinqi Wang (11086049)

“…Background<p>Associations between serum uric acid (SUA) and changes in cognitive function are understudied in non-normotensive populations, and many previous studies only considered the baseline SUA at a single time point. We aimed to examine the effects of baseline SUA and 4-year changes in SUA on cognitive changes in the non-normotensive population.…”