The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice by Yoshinobu Yokoyama (836840)

“…Serum levels of HBV DNA, HBsAg and HBeAg in mice transfected with pHBA1.2 were maintained over 5 months. In contrast, those in mice with pHBC1.2 gradually decreased over time and reached undetectable levels within 3 months after transfection. …”

The 30 most commonly mutated genes from selected variants in EBV+ DLBCL identified by whole-exome sequencing. by Fang Liu (13271)

“…<p>Based on the total number of all mutation loci within one somatic mutated gene in a detected region (exonic region, intronic region, intergenic region, UTR, and other regions), the top 5 most frequently mutated genes were <i>MUC16</i>, <i>PRSS3</i>, <i>MUC19</i>, <i>MUC3A</i>, and <i>RLIM</i> in decreasing order.…”

miR-126-3p reduces VEGF secretion and endothelial tube formation. by Yin Xiong (342546)

“…<p><b>(A)</b> miR-126-3p overexpression significantly reduced secreted VEGF levels in TPC-1 and FTC-133 cell lines but not XTC-1 cells. * p < 0.5. …”

Table_1_A novel form of transcutaneous electrical nerve stimulation for the reduction of dysesthesias caused by spinal nerve dysfunction: A case series.docx by Yuki Nishi (7486787)

“…Background<p>Current therapeutic interventions for dysesthesias caused by spinal cord dysfunctions are ineffective. We propose a novel intervention using transcutaneous electrical nerve stimulation (TENS) for dysesthesias, and we present an in-depth case series.…”

Table_2_A novel form of transcutaneous electrical nerve stimulation for the reduction of dysesthesias caused by spinal nerve dysfunction: A case series.docx by Yuki Nishi (7486787)

“…Background<p>Current therapeutic interventions for dysesthesias caused by spinal cord dysfunctions are ineffective. We propose a novel intervention using transcutaneous electrical nerve stimulation (TENS) for dysesthesias, and we present an in-depth case series.…”

Table_3_A novel form of transcutaneous electrical nerve stimulation for the reduction of dysesthesias caused by spinal nerve dysfunction: A case series.docx by Yuki Nishi (7486787)

“…Background<p>Current therapeutic interventions for dysesthesias caused by spinal cord dysfunctions are ineffective. We propose a novel intervention using transcutaneous electrical nerve stimulation (TENS) for dysesthesias, and we present an in-depth case series.…”

Model for distinct G-protein modulation of <i>I</i>_<i>Ba</i> and <i>I</i>_<i>Ca</i> mediated by Ca_v2.2. by Jessica R. Thomas (20691419)

“…<p>(A, B) Ca_v2.2 channels are potentiated by PIP2 binding and inhibited by Gβγ binding to the channel. …”

A Simple Modified Technique of Pleuropericardial Window: Towards 0% Recurrence by Hanan M. Hemead (14224684)

“…The latter has proved to have lower incidence of recurrence; however, the technique has been continuously refined to improve the recurrence-free survival and decrease postoperative morbidity. We herein present a novel simple modification to minimize recurrence by anchoring the free edges of pericardial fenestration overlying the superior vena cava and right atrium to the chest wall. …”

A Simple Modified Technique of Pleuropericardial Window: Towards 0% Recurrence by Hanan M. Hemead (14224684)

“…The latter has proved to have lower incidence of recurrence; however, the technique has been continuously refined to improve the recurrence-free survival and decrease postoperative morbidity. We herein present a novel simple modification to minimize recurrence by anchoring the free edges of pericardial fenestration overlying the superior vena cava and right atrium to the chest wall. …”

NINL and DZANK1 associate specifically with complementary subunits of the cytoplasmic dynein 1 motor complex. by Margo Dona (816015)

“…MO-injection of sub-effective concentrations of <i>ninl</i> (0.5 ng/nl) (e-e”) or <i>dync1h1</i> (1 ng/nl) (f-f”) generates larvae with a normal phenotype and normal OS length, compared to wildtype larvae (b-b”) and control MO-injected larvae (c-c”). …”

The 452 registrations of the 750 feature vectors after dimension reduction using the AI algorithm autoencoder, the 6 clusters obtained with the DBSCAN clustering algorithm are colo... by Gerhard Fritsch (405224)

Table_1_Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and N... by Yee Qian Lee (10727655)

“…Increased caspase-3 activity and decreased bcl-2 concentration upon treatment indicate that MS13 induces apoptosis in these cells in a dose- and time-dependent manner. …”

Transgenic pmes-<i>Bmp4</i> reactivates Smad1/5/8 signaling in the dermal mesenchyme in <i>Gpr177^K14</i>/Tg-pmes-<i>Bmp4</i>. by Xiao-Jing Zhu (645748)

“…P-Smad1/5/8 activity (white arrowheads) is preferentially decreased in dermis of limb skin in <i>Gpr177^K14</i> mice and increased in dermis of <i>Gpr177^K14</i>/Tg-pmes-<i>Bmp4</i> mice (green arrowheads) (A–C). …”

Discovery of Potent, Selective, and Brain-Penetrant 1<i>H</i>‑Pyrazol-5-yl‑1<i>H</i>‑pyrrolo[2,3‑<i>b</i>]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors by Makoto Fushimi (1714441)

“…Scaffold hopping and lead optimization of <i>N</i>-(2,4-difluorobenzyl)-3-(1<i>H</i>-pyrazol-5-yl)­imidazo­[1,2-<i>b</i>]­pyridazin-6-amine <b>1</b> guided by a cocrystal structure of compound <b>1</b> bound to ALK resulted in the identification of (6-(1-(5-fluoropyridin-2-yl)­ethoxy)-1-(5-methyl-1<i>H</i>-pyrazol-3-yl)-1<i>H</i>-pyrrolo­[2,3-<i>b</i>]­pyridin-3-yl)­((2<i>S</i>)-2-methylmorpholin-4-yl)­methanone <b>13</b> as a highly potent, selective, and brain-penetrable compound. …”

Table 1_Case report: A severe case of zoledronate-associated diffuse orbital inflammation and uveitis in a patient with metastatic breast cancer.docx by Pushpinder Kanda (5125214)

“…We report a case of simultaneous anterior uveitis and orbital inflammation associated with zoledronate infusion in a patient with metastatic breast cancer. …”

Bayesian skyride plot (BSP) for the three genomic segments of RVFV. by P. O. Ly Soumaré (169424)

Structural maturation of the FC in high pressure frozen cells. by Johanna L. Höög (402710)

Concentration-response curves to acetylcholine (ACh) before/after inhibition of EET formation by PPOH (10 μmol/l) or 17-ODYA (10 μmol/l) in phenylephrine (PE)-preconstricted renal... by Dandan Yin (4373071)

The effect of IL-17A on IκBζ - RGS4 signaling. by Hirotada Akiho (559455)

“…(<b>F</b>) The effect of IL-17A, IL-1β, or IL-4 on RGS 4 activity was assessed with or without SN50, a p65 translocation inhibitor, or IκBζ siRNA (n = 4∼5). …”

Image 5_Investigation of Tongqiao Huashuan Granules’ effect on hippocampal neuron autophagy in vascular dementia rats via the PI3K/Akt-mTOR signaling pathway using network pharmaco... by Xiaoqu Jiang (20912471)