Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia by Mary E. Irwin (293687)

“…In two human Ph+ALL cell lines, inhibition of ErbB kinase activity with canertinib resulted in a dose-dependent decrease in the phosphorylation of an ErbB kinase signaling target p70S6-kinase T389 (by 60% in Z119 and 39% in Z181 cells at 3 µM). …”

S1 File - by Chantelle M. de Vet (16535257)

“…The student’s RV-GLS consistency was poor during the first 25 measurements, moderate-to good during the second 25 measurements and again poor-to-moderate during the final 50 measurements. Repeated measurements analysis showed a significant decrease in variability of the LV- and RV-GLS score differences between the expert and trainees over time (<i>p</i>_adj<0.001), which was not significantly different between trainees. …”

GLS analysis with 2D-STE software. by Chantelle M. de Vet (16535257)

“…The student’s RV-GLS consistency was poor during the first 25 measurements, moderate-to good during the second 25 measurements and again poor-to-moderate during the final 50 measurements. Repeated measurements analysis showed a significant decrease in variability of the LV- and RV-GLS score differences between the expert and trainees over time (<i>p</i>_adj<0.001), which was not significantly different between trainees. …”

LS-PGC-1β^−/− mice exhibit decreased expression of TCA and ETC enzymes and mtDNA content. by Kari T. Chambers (106919)

Pairwise correlations of excitatory neurons in APP/PS1 mice are decreased in dCA1, but increased in vCA1. by Udaysankar Chockanathan (18510288)

Decreased dendritic spine density and mEPSC amplitude in the DG of Arf4^+/− mice compared to WT mice. by Sachi Jain (108277)

IODVA1 inhibits lamellipodia and circular dorsal ruffle (CDR) formation in MDA-MB-231 cells and decreases Rac activation. by Anjelika Gasilina (8566296)

Inhibition of PI3K activity decreases uptake of Opa_CEA-expressing gonococci via CEACAM1. by Maike Voges (154488)

Quercetin decreases H₂O₂-induced intracellular ROS level in mouse zygotes. by Sha Yu (525972)

Economic review of point-of-care EEG by Adam Green (14072544)

“…<p><b>Aims:</b> Point-of-care electroencephalogram (POC-EEG) is an acute care bedside screening tool for the identification of nonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE). …”

More focal female offspring produced on dishes where the prior occupant was a related female, while more conspecific offspring were produced on dishes where the female was unrelate... by Emily Rakosy (20939774)

Necdin deficiency decreases <i>p16</i> expression and increases <i>Cdk1</i> expression in the embryonic neocortex. by Ryohei Minamide (505053)

Blockade of kinin B₁R in the chronic disease phase decreased the clinical symptoms and neuroinflammation in the EAE model. by Rafael C. Dutra (205755)

T310A mutation decreases TSP50’s ability to interact with NF-κB:IκBα complex and to promote NF-κB signaling. by Yu-Yin Li (323887)

Silencing of SphK1, but not SphK2, decreases HPAEC migration by S1P in wound healing ECIS assay. by Evgeny V. Berdyshev (307465)

Image_1_Decreased Compressional Sound Velocity Is an Indicator for Compromised Bone Stiffness in X-Linked Hypophosphatemic Rickets (XLH).TIFF by Adalbert Raimann (469799)

Decreased intracellular ROS and associated DNA damage following RNAi-mediated knockdown of p66Shc in early bovine embryos. by Dean H. Betts (202743)

“…Different letters above the histogram bars represent significant differences (P<0.05) in mean phospho-γ-H2A.X fluorescent intensities. Scale bar, 50 µM.…”

FGFR4 ASO treatment increased fatty acid oxidation and decreased <i>de novo</i> fatty acid synthesis. by Xing Xian Yu (438799)

Inclusion of TPP side chains result in decreased melanoma cell mitochondria membrane potential, oxygen consumption, and increased DHE oxidation. by Kyle C. Kloepping (9928265)

“…At the 25 min mark, 1.0 μM 12-TPP was added to treatment A375 cells followed by the sequential addition of 2.5 μM oligomycin at the 60 min mark, 0.3 μM oligomycin at the 90 min mark, and 5.0 μM rotenone/antimycin A at the 120 min mark. …”

Rb fraction decreases KA-induced loss of hippocampal GAD67+ interneurons during chronic period after KA injection. by Kangning Xu (589825)