Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

ST2-104 decreases the Aβ_25-35-mediated increase in intracellular Ca²⁺. by Yingshi Ji (9013004)

Stress strain curves (from a1 to f1), stress—AE count plots (from a2 to f2) and stress—cumulative AE count plots (from a3 to f3) for the sample temperatures of 20°C, 50°C, 100°C, 1... by Nazlı Tunar Özcan (14833635)

A prepubertal CD decreases plasma leptin and cholesterol concentrations in adulthood despite a chronic HFD in Sprague-Dawley male rats. by Ana Aguilar-Lozano (20614619)

Anthelmintics Derived from the Kinase Inhibitor SGI-1776 for the Treatment of Gastrointestinal Worm Infections by Mostafa A. Elfawal (22430138)

“…The unexpected SAR of compound <b>15</b> can be explained by computational modeling. We demonstrate the efficacy of optimized compound <b>50</b> as a new oral anthelmintic, which demonstrated better gut restriction properties and significantly reduced the fecundity of T. muris whipworm adults in infected mice. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

A decreased yield of RNP1, RNP2 and RNP5 formation in the presence of protein aGAR1 is counteracted by RNA-S by Bruno Charpentier (9519)

Whole sample storing experiment: Mean FECs of day 0, day 1 and day 2 for hookworm, <i>A</i>. <i>lumbricoides</i> and <i>T</i>. <i>trichiura</i>. by Felix Bosch (10024550)

Recombinant α-SNAP halts the AR at a stage when SNAREs are monomeric. by Facundo Rodríguez (213557)

“…<p><i>A</i>, we incubated SLO-permeabilized sperm with 300 nM α-SNAP for 10 min at 37°C followed by 100 nM light chain of TeTx, and 0.5 mM CaCl₂ for an additional 10 min (<i>G</i>, <i>H</i>, <i>I</i>). …”

Inhibition of ILK Decreases Bipolar and Multipolar Cytokinesis while Increasing Survival of Multinucleated Cells. by William K. A. Sikkema (574881)

Study design and bodyweight evolution. by Rodrick Montjean (400649)

Injurious ischemia in primary cortical cultures induces a strong reduction in histone acetylation and a rapid decrease in CBP protein levels. by Ferah Yildirim (584888)

A1, A3 impact force time-history curves. by Khalil AL-Bukhaiti (16015543)

“…The axial compression ratio ranged from 0.05 to 0.13 when the impact curve reached its maximum deflection before the component’s impact resistance decreased. Analysis of the impact point and inclined crack location revealed that axial load affects the maximum local concrete. …”

Total soluble protein contents of fat bodies from queens sampled at different seasonal time points. by Mark J. Carroll (3605582)

CDK2/Speedy A localization in <i>Cdk2</i>^{<i>−/−</i>} and <i>Speedy A</i>^{<i>−/−</i>} spermatocytes. by Nathan Palmer (264897)

“…Highlighted by dashed lines are intervals in which telomeres were found to have a 50%–74% decrease in signal and a 75%–100% decrease in signal. …”

PCA analysis of QMP residues recovered from nest worker bodies at different seasonal time points. by Mark J. Carroll (3605582)

Predictive value of RVT1 for the decreased RV ejection fraction (RVEF) and poor outcome in pulmonary arterial hypertension (PAH). by Ryotaro Asano (11767131)

Deuterium uptake profiles (data points) and maximum-entropy fits (smooth curves [54]) vs. H/D exchange period (log₁₀ scale) for selected segments of free and complexed A... by Yeqing Tao (4348336)