Preparation, X-ray Structure, and Reactivity of an Osmium-Hydroxo Complex Stabilized by an N-Heterocyclic Carbene Ligand: A Base-Free Catalytic Precursor for Hydrogen Transfer from... by Ricardo Castarlenas (1709752)

“…Complex <b>3</b> is also obtained in a two-step procedure involving the reaction of <b>2</b> with NaBH₄ to give (η⁶-<i>p</i>-cymene)OsH₂(IPr) (<b>4</b>) and the protonation of the latter with HOTf. …”

8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects by María del Pilar Olaya (12848792)

“…FCS303 inhibited monoamine oxidase B (MAO-B) with an IC50 of 5.46 ± 0.36 µM; however, there was no effect on monoamine oxidase A (MAO-A). The oral administration of FCS303 led to a significant reversal of hypokinesia in the reserpine model (at 24 h, doses of 100 and 200 mg/kg) and in the levodopa/carbidopa potentiation assay (at 2 and 24 h, dose of 200 mg/kg). …”

Data Sheet 1_Global burden of ischemic heart disease attributable to ambient and household PM2.5 exposure: a comprehensive analysis (1990–2021) from socioeconomics perspective.pdf... by Chenran Zhang (4443106)

“…</p>Results<p>From 1990 to 2021, age-standardized rates (ASMR, ASDR) of IHD attributable to ambient PM_2.5 declined to 20.85 per 100,000 (AAPC = −0.7), with attributable to household PM_2.5 decreased to 9.02 per 100,000 (AAPC = −2.49). …”

Supplementary file 1_Global, regional, and national burden of iodine deficiency for women of reproductive age, 1990–2021: a systematic analysis based on the Global Burden of Diseas... by Taotao Wang (115296)

“…</p>Methods<p>Utilizing data from the Global Burden of Disease Study 2021, this study reports age-standardized rates per 100,000 population and average annual percentage changes (AAPCs) in incidence, prevalence, and years lived with disability (YLD) of iodine deficiency among WRA, facilitating a comparative analysis of the burden across regions and nations. …”

Image_2_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat (Tri... by Mario Soccio (12961406)

“…Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Table_1_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat (Tri... by Mario Soccio (12961406)

“…Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Image_1_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat (Tri... by Mario Soccio (12961406)

“…Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Immunofluorescence images from age-matched 3-month old Tg (A) and control (B) rats and from age-matched 7-month old Tg (C) and control (D) rats. by Margaret R. Lentz (364986)

“…Each row shows GFAP staining in yellow, NFH staining in Blue and a composite image of both (magnification 100X, scale bar = 40 µm). …”

Data_Sheet_1_Potential lipid-lowering effects of Ulmus macrocarpa Hance extract in adults with untreated high low-density lipoprotein cholesterol concentrations: A randomized doubl... by Ye Li Lee (14036589)

“…</p>Results<p>UME over 12 weeks led to a greater decrease in LDL-C, TC, and ApoB concentrations than did the placebo as follows: by 18.1 mg/dl (P < 0.001); 23.3 mg/dl (P < 0.001); 9.3 mg/dl (P = 0.018), respectively. …”

Data_Sheet_1_Electroacupuncture for the Prevention of Postoperative Cognitive Dysfunction Among Older Adults Undergoing Hip and Knee Arthroplasty: A Systematic Review and Meta-Anal... by Liang Ou (73724)

“…<p>Background: Postoperative cognitive dysfunction (POCD) is a common surgical complication in elderly patients undergoing hip and knee replacement. …”

Image4_Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated L... by Pedro A. Jurado-Camacho (12571783)

“…We used an LD pruning using a 50-kb sliding window size, a 5-kb window step size and a r² threshold of 0.1.…”

Image1_Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated L... by Pedro A. Jurado-Camacho (12571783)

“…We used an LD pruning using a 50-kb sliding window size, a 5-kb window step size and a r² threshold of 0.1.…”

Image3_Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated L... by Pedro A. Jurado-Camacho (12571783)

“…We used an LD pruning using a 50-kb sliding window size, a 5-kb window step size and a r² threshold of 0.1.…”

Table1_Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated L... by Pedro A. Jurado-Camacho (12571783)

“…We used an LD pruning using a 50-kb sliding window size, a 5-kb window step size and a r² threshold of 0.1.…”

Table2_Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated L... by Pedro A. Jurado-Camacho (12571783)

“…We used an LD pruning using a 50-kb sliding window size, a 5-kb window step size and a r² threshold of 0.1.…”

Image2_Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated L... by Pedro A. Jurado-Camacho (12571783)

“…We used an LD pruning using a 50-kb sliding window size, a 5-kb window step size and a r² threshold of 0.1.…”

Data_Sheet_1_The Efficacy and Safety of Pirfenidone Combined With Immunosuppressant Therapy in Connective Tissue Disease-Associated Interstitial Lung Disease: A 24-Week Prospective... by Jiaqi Wang (369548)

“…However, in IIM patients with a non-UIP tendency, PFD displayed better therapeutic effects than the control (10.50 vs. 1.00%). …”

FIGURE 2 from D-2-HG Inhibits <i>IDH1^mut</i> Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation by Sean T. Pianka (18237413)

“…IDH1^mut inhibitors (C35 = 2 µmol/L; AG881 = 1 µmol/L) enhance growth of <i>IDH1^mut</i><b></b>patient-derived gliomaspheres HK252 (<b>A</b>) and HK211 (<b>B</b>). <b>C,</b> Effect of <i>IDH1^mut</i> forced expression in <i>IDH1^wt</i> gliomaspheres (HK385, HK217, and HK250) on gliomasphere growth relative to vector control [ANOVA, <i>F</i>(1,1056) = 199.0, <i>P</i> ≤ 0.0001; asterisks indicate <i>post hoc</i> Newman–Keuls comparison with vector], showing decreased overall growth in <i>IDH1^mut</i>. …”

Can Topical Insect Repellents Reduce Malaria? A Cluster-Randomised Controlled Trial of the Insect Repellent <i>N,N</i>-diethyl-<i>m</i>-toluamide (DEET) in Lao PDR by Vanessa Chen-Hussey (445411)

“…Intention to treat analysis found no effect from the use of repellent on malaria incidence (hazard ratio: 1.00, 95% CI: 0.99–1.01, p = 0.868). A higher socio-economic score was found to significantly decrease malaria risk (hazard ratio: 0.72, 95% CI: 0.58–0.90, p = 0.004). …”

DataSheet1_Effects of the peripheral CB1 receptor antagonist JD5037 in mono— and polytherapy with the AMPK activator metformin in a monocrotaline-induced rat model of pulmonary hyp... by Patryk Remiszewski (13594804)

“…Animals received metformin (100 mg/kg), JD5037 (3 mg/kg), or a combination of both once daily for 21 days. …”