Effect of cycloheximide on development of <i>tko</i>^<i>25t</i> and wild-type flies. by Esko Kemppainen (64909)

“…Based on pairwise <i>t</i> tests, and considering all the flies of a given sex and genotype cultured at a specific drug concentration as a single population, mean eclosion times were significantly different (<i>p</i> < 0.05) at different cycloheximide concentrations, apart from <i>tko</i>^<i>25t</i> flies of either sex at 100 μg/ml, which were not different from <i>tko</i>^<i>25t</i> flies cultured in the complete absence of the drug. …”

Effect of (CUG)₇ AON on HTT mRNA levels in HD patient derived cell lines 48 hours after transfection. by Melvin M. Evers (207105)

“…<p>Cells were transfected with 100 nM (CUG)₇, non-htt specific h40AON2 (Control AON), transfection agent only (Mock II), or non-transfected cells (Mock I). …”

Non-competitive inhibition of odorant activation of an insect OR by an Orco antagonist. by Sisi Chen (166395)

“…Increasing the concentration of Orco agonist (OLC12) decreases the effectiveness of OX1a. Oocytes expressing Cqui\Orco+Cqui\Or21 were activated with 3 µM or 30 µM OLC12, in the absence or presence of 30 µM or 100 µM OX1a. …”

The adhesion genes are activated by TAp63β but not by ΔNp63β in Caski cells. by Youcef Ben Khalifa (203743)

“…<p>(A) Real-time PCR performed in Caski cells infected with recombinant adenoviruses expressing GFP compared to TAp63β (upper panel) or ΔNp63β (lower panel) at increasing m.o.i. (20, 50 and 100). …”

DYNLT1 knockdown aggravates hypoxia-induced damage of mitochondria: mPT induction, MMP disruption and reduction of cellular viability. by Ya-dong Fang (338292)

“…<b>C</b>, −DYNLT1 cells showed a dramatic decrease in cell viability compared with WT and +DYNLT1 cells; WT and +DYNLT1 cells were not significantly different. …”

The contributions of the saturable and non-saturable components to total flux of [³H]-ADMA into the capillary depletion samples are plotted against the unlabelled ADMA c... by Mehmet Fidanboylu (343341)

“…<p>The measured values are the mean ±SEM for 4-5 mice (homogenate), 4-5 mice (supernatant) and 5 mice (pellet except at 100 μM where it was 1 mouse) at each of the 6 ADMA concentrations and has been [¹⁴C]-sucrose corrected. …”

Global assessment of methylation levels and confounders contributing to hypomethylation in common CNV regions. by Corey T. Watson (250356)

“…Each plot shows a 100 bp moving average. Although a small decrease in methylation level is evident within CNVs compared to flanking regions, overall mean methylation levels within CNV regions (69%) are very similar to the genome average (70%). …”

Supplementary Material for: NANLING: Roxadustat effectiveness/safety in chronic kidney disease-associated anemia with peritoneal dialysis by figshare admin karger (2628495)

“…Baseline hemoglobin was 98.1 ± 10.7 g/L and was <80 g/L in 10 (5.1%). The mean [95% confidence interval] proportion who achieved a hemoglobin concentration ≥100 g/L was 85.1% [79.8%, 90.5%] (T2DM: 89.2% [78.5%, 99.9%]; non-DM: 84.0% [77.8%, 90.1%]). …”

Data_Sheet_1_Ascorbic Acid-Induced Photosynthetic Adaptability of Processing Tomatoes to Salt Stress Probed by Fast OJIP Fluorescence Rise.xlsx by Xianjun Chen (5711882)

“…Lower K- and L-bands and higher I-band were detected on the OJIP transient curves compared, respectively, with salt-stressed plants with and without LYC. AsA application also significantly increased the values of normalized total complementary area (S_m), relative variable fluorescence intensity at the I-step (V_I), absorbed light energy (ABS/CS_m), excitation energy (TR_o/CS_m), and reduction energy entering the electron transfer chain beyond Q_A (ET_o/CS_m) per reaction centre (RC) and electron transport flux per active RC (ET_o/RC), while decreasing some others like the approximated initial slope of the fluorescence transient (M_o), relative variable fluorescence intensity at the K-step (V_K), average absorption (ABS/RC), trapping (TR_o/RC), heat dissipation (DI_o/RC) per active RC, and heat dissipation per active RC (DI_o/CS_m) in the presence or absence of LYC. …”

Pharmacological suppression of local activity abolishes non-linear interactions. by Michael T. Lippert (410615)

“…<p>A: General decrease in average rectified current source density (AVREC) caused by muscimol application (100 ms post-stimulus window, mean of both unisensory stimuli, n = 5, <i>P</i><0.05, U test). …”

Reelin is secreted by GABAergic neurons. by Cecilia Gonzalez Campo (264260)

“…Treatment with BFA did not change the proportion of intense reelin IR neurons: 21.1±1.2% before treatment (n = 8) and 21.0±1.9% after 16 hours (n = 6), whereas it caused a significant decrease in the fraction of punctate reelin IR neurons. …”

Triptolide inhibits NF-κB signaling pathway and its transcriptional activity of its target genes. by Ilona Rousalova (470837)

“…<p>NF-κB activity was assessed using dual-luciferase reporter assay after 24-hour treatment with TNF-α (20 ng/ml) or TNF-α (20 ng/ml) in combination with 100 nM of triptolide. The NF-κB activity was stimulated in the cells treated only with TNF-α, while it was effectively decreased after 100 nM of triptolide in A549 and NCI-H460 cells (A). …”

ADPβS had no effect on two physiologic parameters of Mü ller cell gliosis by Ortrud Uckermann (82321)

“…The currents were measured between the voltage steps to j100 mV and to −160 mV; the holding potential was −80 mV. …”

Effect of topical applications of EHNA on the incidence and multiplicity of histologically characterized skin tumors in high risk SKH-1 mice previously treated with UVB. by Jamie J. Bernard (645781)

“…These tumor-free mice with a high risk of developing skin tumors were treated topically with 3.1 µmole or 0.8 µmole of erythro-9-(2-hydroxy-3-nonyl) adenine hydrochloride (EHNA hydrochloride) or 6.2 µmole caffeine in 100 µl acetone:water (8∶2) once a day five days a week for 16 weeks. …”

Effects of blocking degradation on reconsolidation and extinction. by Remus Osan (3639754)

“…Bars (mean ± S.E.M. of 100 simulations) indicate freezing percentages after initial learning with <i>S</i> = 0.8 (red) and after an intermediate reexposure session (<i>t</i> = 6) with vehicle (<i>S</i> = 0.8, <i>D</i> = 1.25, dark blue), anisomycin (<i>S</i> = 0, <i>D</i> = 1.25, light blue), degradation blockade (<i>S</i> = 0.8, <i>D</i> = 0, light gray) or anisomycin+degradation blockade (<i>S</i> = 0, <i>D</i> = 0, dark gray). …”

QUANTIFICATION OF NEURAL ELEMENTS IN POSTERIOR CRUCIATE LIGAMENT: COMPARISON BETWEEN HEALTHY KNEES AND WITH PRIMARY OSTEOARTHROSIS by MARCELO PARENTE OLIVEIRA (12679956)

“…Methods: In two groups with OA, one of cadavers and another of individuals, the area of neural elements identified in histological sections of PCL with anti-S100 immunohistochemistry was quantified. Results: The overall mean area of the neural elements was 0.96% ± 0.67%, with the value in the cadaver group of 1.02% ± 0.67% and in the OA group of 0.80% ± 0.64%, with a significant statistically difference (p = 0.001). …”

EPB-113 binds to hexameric nsp15 protein. by Benjamin Van Loy (9496075)

“…<p>(A) Thermal shift assay showing the decrease in T_m when 6 µM of nsp15 protein was incubated with 100 µM EPB-113. …”

SF-E inhibits NMDA-induced ROS production without altering cell viability of primary cortical neurons. by Jinghua Jiang (527159)

“…<p>(A) Exposure of SF-E (0–7.5 µg/mL) to primary cortical neurons for 24 h did not alter neuronal viability as assayed by MTT. …”

Light-induced upregulation associates with H2Bub enrichment over transcribed regions. by Clara Bourbousse (150199)

“…(C) Time-series distribution of H2Bub levels over genes that are upregulated by light and marked at 6 h (n = 189). Mean H2Bub levels from all tiles for genes in each category were plotted on a schematized gene scaled to accommodate different transcribed region lengths (represented from 0 to 100%). …”

Comparison between α1β2γ2 and α3β2γ2 GABA-channel currents elicited by brief GABA applications by Andrea Barberis (74413)

“…Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd</p> (A) Multiple records of 1 s illustrating channel activity evoked by 2 ms applications of GABA to outside-out patches in two patches excised from human embryonic kidney (HEK) cells expressing single α1β2γ2 (left, 10 m GABA) and α3β2γ2 (right, 50 m GABA) channels (holding potential, −100 mV). …”