Image3_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.JPEG by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Table2_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.DOCX by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Image1_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.JPEG by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Table4_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.docx by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Image2_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.JPEG by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Image7_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.JPEG by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Image5_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.JPEG by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Table3_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.docx by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Table1_The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.docx by Paolo Comeglio (14195007)

“…Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human K_D = 25 nM; rabbit K_D = 12 nM) and high oral bioavailability in rabbits and man. …”

Increase in conjugated linoleic acid content and improvement in microbial and physicochemical properties of a novel kefir stored at refrigerated temperature using complementary pro... by Hamid POURBABA (10465398)

“…A 4-fold increase in the acetic acid value (0.592 g/100 mL) was observed in kefirs supplemented with B. lactis BB-12 along with L. acidophilus LA-5 and L. paracasei 431 (G12). …”

Mapping maternal mortality rate via spatial zero-inflated models for count data: A case study of facility-based maternal deaths from Mozambique by Osvaldo Loquiha (300896)

“…<div><p>Maternal mortality remains very high in Mozambique, with estimates from 2015 showing a maternal mortality ratio of 489 deaths per 100,000 live births, even though the rates tend to decrease since 1990. …”

Table1_A new perspective on selenium’s impact on renal function: European population-based analysis of plasma proteome-mediated Mendelian randomization study.xlsx by Shaojie Fu (9658334)

“…</p>Results<p>In the MR analysis, an increase in selenium level was found to decrease estimated glomerular filtration rate (eGFR). …”

DataSheet1_The Okur-Chung Neurodevelopmental Syndrome Mutation CK2K198R Leads to a Rewiring of Kinase Specificity.PDF by Danielle M. Caefer (12428451)

“…Broadly speaking the mutation leads to 1) a decreased preference for acidic residues in the +1 position, 2) a decreased preference for threonine phosphorylation, 3) an increased preference for tyrosine phosphorylation, and 4) an alteration of the tyrosine phosphorylation specificity motif. …”

A Membrane-bound eIF2 Alpha Kinase Located in Endosomes Is Regulated by Heme and Controls Differentiation and ROS Levels in <i>Trypanosoma cruzi</i> by Leonardo da Silva Augusto (195970)

“…<div><p>Translation initiation has been described as a key step for the control of growth and differentiation of several protozoan parasites in response to environmental changes. …”

Summary of the transport cascade at the plasma membrane in the guard cell model without buffering, showing the hierachy of forces at work upon a charge imbalance. by Guillaume Mestdagh (22656397)

Additional file 3 of C. elegans as a test system to study relevant compounds that contribute to the specific health-related effects of different cannabis varieties by Monique van Es-Remers (13895294)

“…In this assay C. elegans was exposed to different concentrations (5, 50 and 100 μg/mL) of the Non-Polar Fractions both in carboxylated (NPFdec) and non-decarboxylated (NPF) form. …”

Data_Sheet_1_Projecting trends in the disease burden of adult edentulism in China between 2020 and 2030: a systematic study based on the global burden of disease.docx by Xiaofeng Qin (10721592)

“…Males experienced a higher increase than females. However, the standardized rates decreased over the same period. …”

Hypoxia Activates a Ca²⁺-Permeable Cation Conductance Sensitive to Carbon Monoxide and to GsMTx-4 in Human and Mouse Sickle Erythrocytes by David H. Vandorpe (254705)

“…</p><h3>Methodology/Principal Findings</h3><p>We now show by cell-attached and nystatin-permeabilized patch clamp recording from sickle erythrocytes of mouse and human that deoxygenation reversibly activates a Ca²⁺- and cation-permeable conductance sensitive to inhibition by <em>Grammastola spatulata</em> mechanotoxin-4 (GsMTx-4; 1 µM), dipyridamole (100 µM), DIDS (100 µM), and carbon monoxide (25 ppm pretreatment). …”

File S1 - Impact of Glucocorticoid Receptor Density on Ligand-Independent Dimerization, Cooperative Ligand-Binding and Basal Priming of Transactivation: A Cell Culture Model by Steven Robertson (414616)

“…Exposure times of 1500 ms at 100% light intensity were used. F-don values reflect the CFP signal after 30 minutes of DEX stimulation measured in a region of interest in the nucleus of each individual cell. …”

Effect of a roadblock on ParB2-mediated stimulation of <i>oriII</i> activity in <b><i>E. coli</i></b>. by Tatiana Venkova-Canova (424756)

“…<p>Two <i>oriII</i> plasmids, pTVC20 and pBJH218, isogenic except for about 100 bp extra sequences carrying an array of five P1 RepA binding sites (iterons) in the latter, were used to transform BR8706 (<i>recA</i> minus) cells without (#1, #2) and with (#3, #4) an integrated λ prophage (λDKC311). …”