Western blot assay was performed to assess the effect of MDR1 siRNA loaded nanoparticles on expression of P-gp. by Michiro Susa (248432)

“…<p>The expression of P-gp was significantly decreased after application of 30 nM MDR1 siRNA loaded nanoparticles for KHOS_R2 (<i>A</i>) and 100 nM MDR1 siRNA loaded nanoparticles for U-2OS_R2 (<i>B</i>). …”

DataSheet1_SupCAM: Chromosome cluster types identification using supervised contrastive learning with category-variant augmentation and self-margin loss.pdf by Chunlong Luo (14618255)

“…We realized that semantic differences between chromosomes and natural objects should not be ignored, and thus developed a novel two-step method called SupCAM, which could avoid overfitting only using ChrCluster and achieve a better performance. …”

Data Sheet 1_Comparison of trend analysis of varicella zoster disease burden between China and the world 1990–2021 and disease burden forecast 2030.csv by Zhichun Chang (18594517)

“…The age-standardized disability-adjusted life year rate (ASDR) in China decreased significantly, from 17.68/100,000 to 4.66/100,000, while the global ASDR decreased from 19.28/100,000 to 12.31/100,000. …”

Activation of p65, and not p52, is critical to the apoptotic resistance in U2OS cells. by Brian K. Bednarski (259893)

“…Western blot for p65 confirmed significant knockdown. Evaluation of p100 levels revealed a modest decrease of p100 in the cells lacking p65 and complete knockdown in the cells treated with sip100. …”

Poly-Ub-Substrate-Degradative Activity of 26S Proteasome Is Not Impaired in the Aging Rat Brain by Carolin Giannini (410906)

“…Partly, this seems to be due to a decrease in the activity of the ubiquitin-proteasome system, wherein the 20S/26S proteasome complexes catalyse the proteolytic step. …”

An effective “three-in-one” screening assay for testing drug and nanoparticle toxicity in human endothelial cells by Marcela Filipova (165639)

“…Our results indicated that all the tested NP types induced decreases in cell viability after 24 hours at a concentration of 100 μg/ml. …”

Table 1_Global, regional, national epidemiology and trends of Parkinson’s disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021.docx by Yuanrong Luo (20539082)

“…Age-standardized rates of incidence, prevalence, and DALYs increased to 15.63/100,000, 138.63/100,000, and 89.59/100,000. The burden of Parkinson’s disease were higher in males than in females, and showed an increase and then a slight decrease with age. …”

RI-OR2-TAT reduces the brain load of microglia and oxidative damage and stimulates neurogenesis in APP/PS1 transgenic mice. by Vadivel Parthsarathy (285723)

“…<p>Representative images of activated microglia in the cortical region of APP/PS1 mouse brains as shown by Iba1 immunostaining in animals treated with (<b>A</b>) 0.9% saline or (<b>B</b>) 100 nmol/kg RI-OR2-TAT in 0.9% saline; (<b>C</b>) quantitative analysis shows a decrease in mean microglial load in APP/PS1 mice treated with RI-OR2-TAT; detection of 8 oxo-guanine in the brains of animals treated with (<b>D</b>) 0.9% saline or (<b>E</b>) 100 nmol/kg RI-OR2-TAT; (<b>F</b>) quantitative analysis shows a decrease in mean 8 oxo-guanine staining in APP/PS1 mice treated with RI-OR2-TAT; detection of immature neurons as stained for doublecortin in the dentate gyrus of APP/PS1 mice treated with (<b>G</b>) 0.9% saline or (<b>H</b>) 100 nmol/kg RI-OR2-TAT; (<b>I</b>) quantitative analysis shows an increase in mean doublecortin staining in APP/PS1 mice treated with RI-OR2-TAT. …”

DataSheet_1_Polarized distribution of extracellular nucleotides promotes gravity-directed polarization of development in spores of Ceratopteris richardii.docx by Ashley E. Cannon (8395479)

“…These treatments resulted in a significant decrease in gravity-directed polarization. …”

The effects of Hh protein and agonist on vertebrate Smo and Ptc proteins by Maria Frank-Kamenetsky (26382)

“…Blots in (b) and (c) were reprobed with anti-tubulin antibody as a sample loading control. Anti-HA protein blot of cell extracts, fractionated by SDS-polyacrylamide gel electrophoresis, from cells treated with decreasing concentrations of Hh protein (lane 1, 100 nM; lane 2, 50 nM; lane 3, 25 nM; lane 4, 12.5 nM; lane 5, 6.25 nM; lane 6, 3.12 nM), or with vehicle (lane 7), or with increasing concentrations of Hh-Ag 1.2 (agonist; lane 8, 15 nM; lane 9, 31.25 nM; lane 10, 62.5 nM; lane 11, 250 nM; lane 12, 500 nM; lane 13, 1 μM) for 22 hours. …”

Effects of Dp on mitochondrial dysfunction in oxLDL-induced HUVECs. by Xin Jin (108988)

“…<p>HUVECs were pretreated with various Dp concentrations (1, 10, 50 and 100 μM, respectively) for 2 h, and then exposed to 100 μg/mL of oxLDL for another 24 h. …”

Endoscopic endonasal double flap technique for reconstruction of large anterior skull base defects: technical note by Ricardo Landini Lutaif Dolci (7341128)

“…The introduction and routine use of vascularized flaps allowed a marked decrease in this complication followed by a great expansion in the indications and techniques used in endoscopic endonasal approaches, extending to defects from huge tumours and previously inaccessible areas of the skull base. …”

Test of the most likely period associated with orang-utan population decline. by Reeta Sharma (117636)

“…<p>Natural logarithms of the Bayes Factors (BF) have been computed to determine during which of the important phases the populations started to decrease. a) The BF values of parameter <i>T</i> (time since the beginning of the population collapse) for all orang-utan populations were computed for each 500 year time steps and are plotted for last 50,000 years. …”

Arginine-dependent mRNA destabilization. by Tamar Ben-Zvi (3175077)

“…Putrescine can be produced from ornithine via <i>speC</i> and <i>speF</i> encoding a constitutive and inducible ornithine decarboxylase, respectively or from arginine in two steps via <i>speA</i> and <i>speB</i> encoding arginine decarboxylase agmatine ureohydrolase respectively. …”

ndrg4 function is required for the expression of several genes that are essential for vesicle docking. by Laura Fontenas (3371204)

“…<p>(A) qPCR showing a significant decrease in the expression of nsfa, syt1a, stxbp1b but not vamp2 in ndrg4 mutants with mRNA relative expression to ef1a. …”

Ca²⁺ induced swelling in isolated mitochondria. by Jun Li (6494)

“…<p>(<b>A</b>) Representative traces of 100–1000 µmol/L Ca²⁺ induced a decrease in light transmission in the ischemia/reperfusion (I/R) 24 h group. …”

Impact of Climate Change on Sugarcane Yield in Maceió by Lívia Pilar Melo de Oliveira (10393399)

“…The data were analysed in a ten days period, the same time step as the agrometeorological model used for culture. …”

Yolk sac erythropoiesis is impaired in Actb−/− embryos. by Davina Tondeleir (426905)

“…<p>(A) Primitive erythroid colonies (EryP) from E8.5 yolk sacs measured by methylcellulose assays show a dramatic decrease in colony forming potential in <i>Actb^−/−</i> embryos compared to <i>Actb^+/+</i> embryos. …”

Effects of paclitaxel on the total length of neurites per cell in control and treated DRG cultures. by Elena E. Ustinova (283017)

“…Pac was added to cultures at concentrations 0.1 nM–100 nM. As shown, Pac decreases the length of neurites in a concentration-dependent manner both in control (solid bars) and TLR4 knockout mice (open bars). *, p<0.05 versus 0 M of Pac in the same group; #, p<0.05 versus wild type at the same concentration of Pac. …”

Progression index. by Enedino Hernández-Torres (816735)

“…(B) Age-matched patients were divided in high 100*PI (>20) and low 100*PI (<20). Note that R2* values in the low PI group are higher than in the high PI group, supporting the hypothesis of a decrease in R2* with disease progression.…”