Intermolecular Failure of L-type Ca²⁺ Channel and Ryanodine Receptor Signaling in Hypertrophy by Ming Xu (151206)

“…<div><p>Pressure overload–induced hypertrophy is a key step leading to heart failure. The Ca²⁺-induced Ca²⁺ release (CICR) process that governs cardiac contractility is defective in hypertrophy/heart failure, but the molecular mechanisms remain elusive. …”

Fis binding site modifications, Langevin dynamics simulations of DNA breathing, and EMSA experiments, the first set. by Kristy Nowak-Lovato (101951)

“…<p>(A) Langevin dynamics simulations demonstrating suppressed local DNA breathing dynamics in the FIS1S sequence (compare to FIS1 in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002881#pcbi-1002881-g002" target="_blank">Figure 2</a>). …”

Systematic review of evidence for the impact and effectiveness of the 1-3-7 strategy for malaria elimination by Richard J. Maude (9416228)

“…</p><h2>Conclusion </h2><p dir="ltr">Overall, the 1-3-7 approach was effectively implemented with a concomitant decrease in cases in malaria elimination settings, however, it was not possible to quantify impact as it was not implemented in isolation. …”

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…Finally, when the primer had a 3‘-OH, a fluorescence decrease with a rate equal to the rate of nucleotide incorporation was observed with both 0 and +1 position reporters. …”

<em>Bacillus anthracis</em> Interacts with Plasmin(ogen) to Evade C3b-Dependent Innate Immunity by Myung-Chul Chung (226513)

“…PLG-bound spores were capable of exhibiting anti-opsonic properties by cleaving C3b molecules <em>in vitro</em> and in rabbit bronchoalveolar lavage fluid, resulting in a decrease in macrophage phagocytosis. Our findings represent a step forward in understanding the mechanisms involved in the evasion of innate immunity by <em>B. anthracis</em> through recruitment of PLG resulting in the enhancement of anti-complement and anti-opsonization properties of the pathogen.…”

An Inducible Cell-Cell Fusion System with Integrated Ability to Measure the Efficiency and Specificity of HIV-1 Entry Inhibitors by Alon Herschhorn (198447)

“…<div><p>HIV-1 envelope glycoproteins (Envs) mediate virus entry by fusing the viral and target cell membranes, a multi-step process that represents an attractive target for inhibition. …”

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…Finally, when the primer had a 3‘-OH, a fluorescence decrease with a rate equal to the rate of nucleotide incorporation was observed with both 0 and +1 position reporters. …”

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…Finally, when the primer had a 3‘-OH, a fluorescence decrease with a rate equal to the rate of nucleotide incorporation was observed with both 0 and +1 position reporters. …”

RES complex is associated with intron definition and required for zebrafish early embryogenesis by Juan Pablo Fernandez (5478497)

“…<div><p>Pre-mRNA splicing is a critical step of gene expression in eukaryotes. …”

Multistep Interactions between Ibuprofen and Lipid Membranes by Simou Sun (3089832)

“…Ibuprofen (IBU) interacts with phosphatidylcholine membranes in three distinct steps as a function of concentration. In a first step (<10 μM), IBU electrostatically adsorbs to the lipid headgroups and gradually decreases the interfacial potential. …”

Multistep Interactions between Ibuprofen and Lipid Membranes by Simou Sun (3089832)

“…Ibuprofen (IBU) interacts with phosphatidylcholine membranes in three distinct steps as a function of concentration. In a first step (<10 μM), IBU electrostatically adsorbs to the lipid headgroups and gradually decreases the interfacial potential. …”

Multistep Interactions between Ibuprofen and Lipid Membranes by Simou Sun (3089832)

“…Ibuprofen (IBU) interacts with phosphatidylcholine membranes in three distinct steps as a function of concentration. In a first step (<10 μM), IBU electrostatically adsorbs to the lipid headgroups and gradually decreases the interfacial potential. …”

Multistep Interactions between Ibuprofen and Lipid Membranes by Simou Sun (3089832)

“…Ibuprofen (IBU) interacts with phosphatidylcholine membranes in three distinct steps as a function of concentration. In a first step (<10 μM), IBU electrostatically adsorbs to the lipid headgroups and gradually decreases the interfacial potential. …”

Multistep Interactions between Ibuprofen and Lipid Membranes by Simou Sun (3089832)

“…Ibuprofen (IBU) interacts with phosphatidylcholine membranes in three distinct steps as a function of concentration. In a first step (<10 μM), IBU electrostatically adsorbs to the lipid headgroups and gradually decreases the interfacial potential. …”

The defects of OB in Lgl1 mutants. by Zhenzu Li (3108309)

“…Scale bars represent 1mm in Ac and 200 μm(0), 100 μm (a,c) and 50 μm (b,d) in C.</p>…”

Increased susceptibility to H₂O₂ production and cell death in TrxR2 deficient cells. by Pamela Lopert (114596)

“…At 100 µM, 300 µM and 1 mM PQ concentrations there was a significant increase in H₂O₂ released in the deficient cells compared to mock controls (n = 6) * = p<0.05 as determined 2-way ANOVA. …”

Regulation of spine neck resistance does not generate robust changes in synaptic efficacy. by Allan T. Gulledge (325673)

“…<p>A) Top, ball-and-stick model neuron with 100 spines (200 MΩ neck resistance) along the dendrite. …”

Modulating CFTR expression may limit SHS induced bacterial survival. by Inzer Ni (707909)

“…(D) CSE treatment (in 3C) significantly (**p<0.01) inhibits bacterial phagocytosis, while VRT-532 is unable to restore SHS impaired phagocytosis. (E) In a separate experiment (as described in 3C), media (100μl) was collected, spread on agar plates, and then incubated overnight at 37°C. …”

Hydrodynamic Characterization of Phase Separation in Devices with Microfabricated Capillaries by Anand N. P. Radhakrishnan (6823991)

“…The trailing edge of the liquid slugs (receding meniscus) approached the advancing meniscus at a constant speed, thus leading to a linear decrease of the liquid slug length. …”

Hydrodynamic Characterization of Phase Separation in Devices with Microfabricated Capillaries by Anand N. P. Radhakrishnan (6823991)

“…The trailing edge of the liquid slugs (receding meniscus) approached the advancing meniscus at a constant speed, thus leading to a linear decrease of the liquid slug length. …”