Pyrvinium inhibits Wnt signaling. by Sarika Saraswati (236578)

“…(<b>B</b>) Pyrvinium (100 nM) decreases transcript levels of endogenous Wnt target genes Myc, Dkk-1, and Axin2 as assessed by real-time PCR. …”

Kinetic characterizations of AChR blockade by PQ1–5. by Wan-Chen Lin (658261)

“…<p>(A) Single-channel currents of the AChR in the presence of 100 µM Ach ±5 µM <b>PQ5</b>. …”

Effect of TAK-242 on LPS-induced inhibition of myogenesis. by Yuko Ono (1443175)

“…(B) TAK-242 partially reversed the LPS-induced decrease in myogenic index. Cells were treated as described in (A). …”

Increased susceptibility to H₂O₂ production and cell death in TrxR2 deficient cells. by Pamela Lopert (114596)

“…At 100 µM, 300 µM and 1 mM PQ concentrations there was a significant increase in H₂O₂ released in the deficient cells compared to mock controls (n = 6) * = p<0.05 as determined 2-way ANOVA. …”

Effects of HFD on adipose macrophage infiltration, hypertrophy, and injury in NOX2-FL and mNOX2-KO mice. by Jennifer K. Pepping (4330654)

“…<b>(D)</b> Expression of GADD153/CHOP and GRP78 in tissue homogenates prepared from epididymal adipose depots. Data depict mean ± SEM expression in HFD mice presented as % values in CD mice (100% line on graph). *** indicates significant (p < 0.001) increases in expression in HFD-fed NOX2-FL mice compared to CD-fed NOX2-FL mice, while ### indicates significant (p < 0.001) decreases in expression in HFD-fed mNOX2-KO mice as compared to HFD-fed NOX2-FL mice.…”

Characterization of <em>Abcc4</em> Gene Amplification in Stepwise-Selected Mouse J774 Macrophages Resistant to the Topoisomerase II Inhibitor Ciprofloxacin by Béatrice Marquez (193669)

“…Molecular cytogenetics experiments showed that this overexpression is linked to <em>Abcc4</em> gene overrepresentation, grading from a partial trisomy of Chr 14 at the first step of selection (cells exposed to 100 µM ciprofloxacin), to low-level amplifications (around three copies) of <em>Abcc4</em> locus on 1 or 2 Chr 14 (cells exposed to 150 µM ciprofloxacin), followed by high-level amplification <em>of Abcc4</em> as homogeneous staining region (hsr), inserted on 3 different derivative Chromosomes (cells exposed to 200 µM ciprofloxacin). …”

Retinal structural changes well correlated with the ERG findings. by Victoria Peshti (3966533)

“…<p>(A) Representative retinal sections stained with hematoxylin and eosin demonstrate marked decrease of retinal thickness in KO eyes by the age of 6 months with further thinning by 10 months. …”

Antibacterial activity of rHPL. by Sim-Kun Ng (495657)

“…Control plate (0 µM) was defined as 100%-viable cells. Cell mortality was calculated as the decrease in the colony number compared with the control plate. …”

Pharmacological Wnt inhibition mimics β-catenin silencing in suppressing regenerative potential. by Chang Chen (30907)

“…<p><b>(A-D)</b> Wnt inhibitory factor-1 (WIF-1) treatment phenocopies β-catenin siRNA effects, including wound closure reduction (AB), invasion capacity decrease (CE), and proliferation decline <b>(D)</b>. …”

Flow cytometry analysis of apoptosis. by Igor Santos Fonte Bôa (838040)

“…<p>A) Dot plots showing the apoptosis ratios of kidney cells from Control (n = 4), CIN (n = 6), NAC (n = 6), V10 (n = 4), V100 (n = 4) and V300 (n = 4) groups subdivided into cortex (left panel) and medulla cells (right panel). …”

Random forest identifies metabolites that significantly distinguishes between WT and dKO group of mice. by Samit Ganguly (1792294)

“…RFA identified two groups (WT and KO) with 100% accuracy in both CSF (A) and plasma (B). Metabolites were plotted against their Mean Decrease in Accuracy, calculated by RFA. …”

<i>γ-Mtb</i>-mediated TF induction and TNF-α secretion is mostly independent of CD14. by Hema Kothari (306093)

“…Data is depicted as fold increase in TF activity over control (<b>B</b>) TNF-α levels as determined in ELISA. ns, not statistically significant; # indicates statistically significant decrease compared to LPS alone (<i>P</i><0.05). Data are mean ± SEM (n = 3–6).…”

Inhibition of KDM expression <i>in vivo</i>. by Hanitriniaina Rabeony (596171)

“…Skin sections were stained with Hematoxylin and immunodetection of cytokeratin 10, loricrin, filaggrin, involucrin and S100A7 was performed. Scale bar 100 µm. Results are from one experiment representative of three.…”

Specific induction of FABP4 in neovessels during OIR. by Magali Saint-Geniez (269693)

“…(C) Quantification of circulating FABP4 demonstrated a significant decrease of serum FABP4 levels in OIR P17 WT mice compared to control room air (RA). …”

Elevations of HIF-1α mRNA and protein expressions by HMGB1 and their inhibition by cilostazol. by Hye Young Kim (135983)

“…(C) Time (3, 6, 12, and 24 hr)-dependent increases in HIF-1α protein levels in the presence of 100 ng/ml of HMGB1. (D) Concentration-dependent decrease of HMGB1 (100 ng/ml)-induced HIF-1α protein by cilostazol (CSZ; 1, 10 and 30 µM) and resveratrol (RES, 20 µM). …”

Actin/calmodulin/tubulin, phosphatidylinositol (4,5)-bisphosphate, and ER-Golgi trafficking, are required for asymmetrical inheritance of protein aggregates. by Jia Song (495396)

“…Data are plotted as the mutants' deviation from the wild type in aggregate inheritance (open bars; 100% increase means a two-fold increase in the aggregate inheritance values compared to wild type strains) and removal (black bars; 100% decrease means a two-fold decrease in the inheritance values compared to wild type strains). …”

External bases do not catalyze some McLOV proteins. by Kaley K. El-Arab (733285)

“…In contrast, a Thr27Ile demonstrates spectra consistent with LOV chemistry (E) with a 100-fold decrease in the rate of adduct decay (F). …”

Human movement can disrupt the success of an elimination program. by Milen Nikolov (3360782)

“…Line indicates the mean and shaded area the range observed over 100 samples from the joint posterior distribution of 10 best-fit habitat availability pairs for each cluster. …”

The proportion of homomeric GluR1 AMPA receptors in the post-synaptic sites is not altered following LTP induction. by Agnès Villers (316323)

“…(B) NASPM was added either 45 minutes (filled circles, n = 3) or 1 h45 (open circles, n = 4) after LTP induction by a single train of high-frequency stimulation (100 Hz, 1 s). …”

Simulated Data Accuracy Curves by Mitchell Guttman (78794)

“…At a SNR = 2 we detect 100% true positives with almost no false positives.…”