Pharmacological inhibition of cell death pathways protects neurons against glutamate-induced cell death. by Ujval Anilkumar (4598182)

“…Traces show that blocking key cell death signalling pathways protected neurons against excitotoxicity. B) A heat map of the median population of viable cells 24 h following glutamate excitation (100 μM) illustrates the protective effect of these drugs against glutamate-induced cell death. …”

Transcriptome-Wide Assessment of Human Brain and Lymphocyte Senescence by Mun-Gwan Hong (271202)

“…Few methodological approaches offer the means to explore this question on as broad a scale as gene expression profiling. Here, we have evaluated mRNA expression profiles as a function of age in two populations; one consisting of 191 individuals with ages-at-death ranging from 65–100 years and with post-mortem brain mRNA measurements of 13,216 genes and a second with 1240 individuals ages 15–94 and lymphocyte mRNA estimates for 18,519 genes.…”

Initiation of Methylglucose Lipopolysaccharide Biosynthesis in Mycobacteria by Devinder Kaur (264278)

“…Disruption of <em>MSMEG_5084</em> in <em>M. smegmatis</em> resulted in a dramatic decrease in MGLP synthesis directly attributable to the almost complete abolition of glucosyl-3-phosphoglycerate synthase activity in this strain. …”

Distance from the optimal direction for different levels of reward probabilities. by Jyotika Bahuguna (729510)

“…<p>A) DDM (a, v) and behavioral (RT, accuracy) parameters for reward probabilities: 100% (red), 95% (pink), 90% (yellow) and 75% (khaki) measured for 150 networks. …”

Cell cycle analysis of dinaciclib in apoptotic-proficient and apoptotic-deficient cell lines. by Robert N. Booher (640925)

“…<p>(A) Apoptotic-deficient CA46 cells and apoptotic-proficient Kasumi-1 cells were treated for 24 hr with dinaciclib (100 nM) or mitotic inhibitor paclitaxel (3 µM). …”

TLR4 took part in HMGB1-induced activation of NF- by Fu-ping Wang (5659540)

“…Compared to the HMGB1 stimulation, TLR-4 neutralizing antibody pretreatment resulted in a decrease in NF-kB protein level as well as in phospho-IkBα level, while a concomitant increase in the cytosolic IkBα protein level. …”

Histamine activates both transient and persistent [Ca]_i responses. by Iustin V. Tabarean (302441)

“…The TRPC channel blocker SKF96365 (100 µM) decreases the histamine activated [Ca]_i plateau but does not affect the transient increase activated by the neurotransmitter. …”

Pyrvinium inhibits Wnt signaling. by Sarika Saraswati (236578)

“…(<b>D</b>) Pyrvinium stimulates CK1α activity. CK1α (100 nM) was incubated with recombinant casein (100 nM) plus or minus pyrvinium (10 nM) in a kinase reaction containing [γ³²P]ATP followed by SDS-PAGE and exposure to PhosphoImager screen. …”

KIR specificity is protective against viruses evolving MHC-like decoys. by Paola Carrillo-Bustamante (469426)

“…(A) The MHC down-regulating virus (red line) is fitter than the wild type virus (blue line), infecting more individuals and resulting in a larger decrease of the total population size (grey line). …”

Mutation of LUSH^D118 does not affect the responses of OR67d neurons to cVA. by Carolina Gomez-Diaz (408669)

“…There are no statistically significant differences in cVA sensitivity due to genotype (ANOVA, <i>p</i> = 0.1183). There is a small but significant decrease in cVA-sensitivity at 100% cVA stimulation for LUSH^D118A when compared to LUSH^wt (<i>p</i><0.05; Tukey's multiple comparison tests). …”

Complexity for ephaptic-off and ephaptic-on networks. by Gabriel Moreno Cunha (20390408)

“…Both models were simulated for N = 100. (b) Complexity for different synaptic intensity. …”

Effects of ABP135_G1-G3 on actin filament severing. by Dong Qian (419482)

“…<p>A total of 2 μM preformed CapG capped pyrene actin filaments was diluted to 100 nM in S2 buffer with various concentrations of ABP135_G1-G3, and immediately, the decrease in pyrene fluorescence intensity that accompanied actin depolymerization was monitored for 300 s.…”

Newborn screening process, illustrating specimen collection through result reporting. by Marci K. Sontag (8662200)

“…NewSTEPs 360 supported state/territorial NBS programs to address challenges associated with the pre-analytical and analytical phases of the NBS process by implementing various activities, including 1) providing education to birthing centers and midwives about the importance of timely collection and shipment of specimens; 2) shortening transit time by optimizing shipping methods; 3) expanding laboratory operating hours to decrease the time from specimen receipt to results reporting; 4) improving the efficiency of laboratory workflows; and 5) developing a health information technology infrastructure to improve the transmission of electronic demographic information, laboratory orders, and results between the NBS laboratory and health care providers.…”

Integrative model incorporating transcript, phospho-protein, and metabolite changes across the strain panel. by Kevin S. Myers (424665)

“…Metabolites measured previously [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008037#pgen.1008037.ref029" target="_blank">29</a>] are colored to indicate an increase (orange) or decrease (magenta) in abundance in Y128 versus Y22-3 grown anaerobically on xylose. …”

Fig 3 - by Alexa Petrucciani (13262165)

“…We divide the simulations into two groups with traditional CFU greater than 6000 (differentially controlled simulations) or less than or equal to 6000 (similarly controlled simulations) at time step 550 (about day 2.29). b) Due to the overlap in the experimental data for CFU, some spheroid and traditional simulations perform similarly. c) The similarly controlled runs have a higher baseKillingProbability than the differentially controlled runs. …”

CK2 Phosphorylates Sec31 and Regulates ER-To-Golgi Trafficking by Mayuko Koreishi (101892)

“…Sec31 is a component of the outer layer of COPII coat and has been identified as a phosphoprotein. …”

<b>Organic farming drives higher diversity of beetles, with more predators and less pests</b> by Bounsanong Chouangthavy (14433156)

“…Concerning the abundance and family richness of beetles for each month, there was an increase from January to March, followed by a slight decrease until July. It is clearly seen that our finding shows significant evidence to assist as a step toward to contribute government policy, particularly to the Ministry of Agriculture, which plays a crucial role in promoting and supporting the development of organic agriculture in Lao PDR. …”

UCH-L5 regulates inflammasome activity in human macrophages. by Evangel Kummari (719636)

“…<p><b>(A). Exposure of THP-1 macrophages to b-AP15 inhibitor leads to decrease in IL-1β upon inflammasome activation.…”

Presence of energy-dependent and Sodium-driven transporters in parent strain of <i>V. fluvialis</i>. by Priyabrata Mohanty (325471)

“…<b>B.</b> Decrease in the levels of intracellular concentration of ethidium bromide in the parent strain in the presence of 100 mM NaCl. …”

Pain stretching behavior during labor. by Ting Yang (189879)

“…Dams from sevoflurane or xenon groups had a significant decrease of stretches compared to control group. …”