Post-Translational Control of IL-1β via the Human Papillomavirus Type 16 E6 Oncoprotein: A Novel Mechanism of Innate Immune Escape Mediated by the E3-Ubiquitin Ligase E6-AP and p53... by Martina Niebler (440620)

“…Hence, attenuation of IL-1β by the HPV16 E6 oncoprotein in immortalized cells is apparently a crucial step in viral immune evasion and initiation of malignancy.…”

Nearly 1000 Protein Identifications from 50 ng of <i>Xenopus laevis</i> Zygote Homogenate Using Online Sample Preparation on a Strong Cation Exchange Monolith Based Microreactor Co... by Zhenbin Zhang (1444888)

“…Dramatically improved performance was produced by coupling the reactor to a longer separation capillary (∼100 cm) and a Q Exactive HF mass spectrometer. 975 protein groups and 3749 peptides were identified from 50 ng of <i>Xenopus</i> protein using the online sample preparation method.…”

Table 1_Danggui Buxue Decoction attenuates 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone—induced lung cancer growth in A/J mice by suppressing HIF-1α/VEGF-mediated angiogenesis.do... by Wu Chen (569414)

“…</p>Methods<p>Potential therapeutic targets of DBD against LC were identified through database mining (OMIM, TTD, GeneCards) using topological analysis. A/J mice received intraperitoneal injections of NNK (100 mg/kg) to induce lung tumors. …”

Data Sheet 1_Global, regional, and national trends in ischaemic stroke burden and risk factors among adults aged 20 + years (1990–2021): a systematic analysis of data from the Glob... by Sibo Liu (9975065)

“…</p>Results<p>From 1990 to 2021, the global age-standardized prevalence of IS decreased from 1,309 (95% UI 1,151 to 1,481) to 1,266 (95% UI 1,120 to 1,423) cases per 100,000 population, with an average annual decrease of −0.12%. …”

Datasheet1_Impact of hypertensive heart disease, risk factors, and age-period-cohort models across 204 nations and regions from 1990 to 2019: a global perspective from the 2019 glo... by Guoliang Gao (2910503)

“…The APC model revealed an association between mortality rates and age, with a decreasing mortality risk over time and improved survival rates for a later birth cohort.…”

DataSheet_1_A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intrav... by Katherine E. R. Smith (17308126)

“…</p>Methods<p>We developed an OV with a Vesicular Stomatitis Virus (VSV) vector modified to express interferon-beta (IFN-β) and Tyrosinase Related Protein 1 (TYRP1) (VSV-IFNβ-TYRP1), and conducted a Phase 1 clinical trial with a 3 + 3 design in patients with MUM. …”

Fractions of Selaginella convoluta (Arn.) Spring (Selaginellaceae) attenuate the nociceptive behavior events in mice by L. A. R. Oliveira-Macêdo (6625403)

“…<div><p>Abstract Selaginella convoluta (Arn.) Spring is a species popularly known as “jericó”, and used in folk medicine as analgesic and anti-inflammatory. …”

Fractions of Selaginella convoluta (Arn.) Spring (Selaginellaceae) attenuate the nociceptive behavior events in mice by L. A. R. Oliveira-Macêdo (6625403)

“…<div><p>Abstract Selaginella convoluta (Arn.) Spring is a species popularly known as “jericó”, and used in folk medicine as analgesic and anti-inflammatory. …”

Adenoviral Type 5 (Ad5) vector expression in a host organ panel in tumor bearing immunodeficient <i>Rag2^−/−</i>, and <i>hCAR:Rag2^−/−</i> composite mice.... by Zhi Hong Lu (389413)

“…A and B: n = 5–6 mice, combined from 3–6 independent experiments, C and D: n = 3–4 mice combined from 3–4 independent experiments Magnification: 100X, Red: endomucin/CD31, Green: EGFP immunofluorescence, Blue: DAPI.…”

Essential oil of Pterodon polygalaeflorus Benth attenuates nociception in mice by A.N. Coelho-de-Souza (5837000)

“…At 30 mg/kg, EOPPgfl also decreased thermally stimulated nociception. Nociception may be related to inflammatory and antiedematogenic activity and at doses ranging 10–100 mg/kg, EOPPgfl blocked dextran- and carrageenan-induced edema. …”

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-... by Schumacher, Austin E.

“…In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. …”
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Solid-State N–H···O/O–H···N Tautomerism in Resonance-Assisted 1‑(Arylazo)-2-Naphthols and Its Through-Space <i>π* ← π</i> Perturbation in TCNQ Cocrystals. A Variable-Temperature X‑... by Gastone Gilli (1927528)

“…It is shown that cocrystallization with TCNQ induces two main effects: (i) in TCNQ itself, a significant change from quinoid to aromatic geometry, from which a CT of some 0.40 <i>e</i> can be estimated; (ii) in azonaphthols, a shift of the N–H···O ⇄ N···H–O equilibrium toward the pure N–H···O tautomer, accompanied by a decrease of π-delocalization inside the conjugated ···HN–NC–CO··· resonant fragment. …”

Temporal development of coverage of <i>Termitomyces</i> diversity by GenBank ITS sequences based on optimal clustering parameters (thick lines) as well as a selection of suboptimal... by Huxley M. Makonde (380019)

“…The suboptimal threshold values were varied between 1% and 5% in steps of 1% and are either arranged in decreasing or increasing order, depending on the context; see the text for further details. …”

RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis by M. J. A. M. Clausen (2966817)

“…Our data revealed that promoter methylation is a mechanism resulting in downregulation of RAB25 expression in pN+ OOSCC and decreased expression is associated with lymph node metastasis. …”

Data_Sheet_1_Impact on plant productivity under low-fertility sandy soil in arid environment by revitalization of lentil roots.pdf by Mohamed A. Abd El-hady (13197339)

“…Thus, P rates were applied at four rates 0 (P0; control), 50 (P1), 75 (P2), and 100 (P3) kg phosphorus pentoxide (P₂O₅) ha^–1. …”

Data Sheet 1_Global, regional, and national burden and trends of intracerebral hemorrhage among adolescents and young adults aged 15–39 years from 1990 to 2021: a comprehensive tre... by Xuanchen Liu (12188147)

“…Prevalence rates also decreased from 124.44 to 94.58 per 100,000. Mortality rates and DALYs exhibited similar downward trends. …”

Time-Response EEG activity of SR9009 during the dark phase Mice were dosed with SR9009 at different time points (ZT15, ZT18, ZT21) on separate days in order to generate a Time-Resp... by Ariadna Amador (2560231)

Parametric analysis of evoking KCs by directly versus indirectly depolarizing RE. by Rachel A. Mak-McCully (634502)

“…B, When stimulating 6 PY neurons projecting to all RE neurons, the spindling in all three populations drops 100 ms after stimulation is applied at a level of 20pA or higher (red asterisk). …”

The goal-reaching success rate 〈<i>P</i>_<i>R</i>〉 as a function of motion noise <i>D</i>_<i>m</i> and neural noise <i>D</i>_<i>s</i>. by Shogo Yonekura (4672330)

“…As shown in panels <b>(C)</b> and <b>(F)</b>, if <i>K</i> is large enough to realize a 100% success rate, the <i>P</i>_<i>R</i> monotonically decreases with <i>D</i>_<i>m</i>. …”

The effect of the genetic deletion of P2rx7 on ATP-evoked tritiated (A, C) and endogenous (B) glutamate efflux (D) mRNA expression and (E–I) immunofluorescence staining of the NR2B... by Cecilia Csölle (425362)

“…After a 60-min preperfusion, the basal extracellular [³H]Glu efflux was lower in P2rx7−/− mice. 6-min perfusion of ATP (10 mM) resulted in a transient increase in the efflux of [³H]Glu in P2rx7+/+ mice, which peaked at 6 min after ATP administration and gradually decreased to baseline levels after 12 min. …”