Image7_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet4_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet3_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet7_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image2_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image6_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Sections of testis from 6 month old male medaka stained with H&E. by Hilary D. Miller (29470)

“…F: Animal exposed to 10.0 µg/L EE2 for 14 days has a severe thickening of the interstitium, increased vacuolization, and an overall decrease in germinal epithelium. …”

Replacement of chicken skin with canola oil in chicken nuggets by Sandra Tiemi Seó (16453032)

“…There was a decrease in AI (T0%-raw vs. T100%-fried, 0.39 vs. 0.10) and IT (T0%-raw vs. …”

Limb phenotypes and lung histology of <i>Fgf10</i>-CRISPR F0 embryos at E16.5. by Munenori Habuta (9525357)

“…In type I and type II embryos, there is a significant decrease in the number compared with that of wild type. …”

Increase in decidual VEGF expression is associated with increase in macrophage number and dramatic upregulation of M2 markers in the decidua. by Karen C. Wheeler (4760370)

“…Scale bars: A-D, 100 μm and E-H, 40 μm. I, qPCR analysis of VEGF and M1 (CXCL10, CCR7, and IL12) and M2 (CD206, CD163, and CCL17) markers in first trimester decidual tissue compared with secretory phase endometrium. …”

The <i>Citrobacter rodentium</i> type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses by Cedric N. Berger (4544008)

“…<i>rodentium</i>. This overlapped with a decrease in STAT3 phosphorylation in IECs. Importantly, while the reduced CCH and abundance of antimicrobial proteins during Δ<i>espO</i> infection did not affect <i>C</i>. …”

DataSheet1_Arctic stratosphere changes in the 21st century in the Earth system model SOCOLv4.pdf by Pavel Vargin (16809465)

“…In the late 21st century, the strengthening of the zonal mean meridional heat flux with a maximum of up to 20 K m/s (∼25%) in the upper stratosphere close to 70°N in January–February is obtained in the moderate scenario of GHG emission, while only a slight increase in this parameter over 50 N–60 N with the maximum up to 5 K m/s in the upper stratosphere and a decrease with the comparable values over the high latitudes is revealed in the severe GHG emission scenario. …”

Toxic activity of AS56 on the larval feeding behavior of <i>S. exigua.</i> by Niayesh Shahmohammadi (21262234)

“…(B) A choice test involving L3 larvae treated with either DMSO or AS56, as well as diets treated with DMSO or AS56, was conducted using a Y-tube olfactometer. …”

Data_Sheet_1_Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic In... by Matthew R. Barron (8533815)

“…<p>Inflammation is considered a mechanistic driver of Alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (NFTs). …”

<i>TcPiezo-CKO</i> responses to hypoosmotic stress. by Guozhong Huang (673424)

“…(D) Tet-induced <i>TcPiezo2 Tet-OFF</i> cells (+Tet) had a significant decrease of intracellular Ca²⁺ rise, compared to non-induced cells (-Tet). 100 µ M EGTA was added to remove extracellular Ca^2<i>+</i>, abolishing Ca²⁺ entry, as indicated. …”

Motion of FisB clusters is not coupled to cell wall synthesis, or pH and voltage gradients across the cell membrane. by The PLOS Biology Staff (11836235)

“…Upon treatment with fosfomycin, GFP-Mbl filaments stop moving, which is reflected as a decrease in asymmetry (<i>p</i> = 0.0044), whereas mGFP-FisB’s motion is unaffected (<i>p</i> = 0.8655). …”

Knockdown of TP53 increases apoptosis induction by low concentration sagopilone. by Sebastian Winsel (222664)

“…White bars indicate the mean percentage of cells characterized by decrease of ΔΨm (ΔΨm low) and black bars indicate cells with ΔΨm low and high propidium iodine signal (PI+) due to plasma membrane rupture. …”

EFFECT OF WATER DEFICIT AND ABSCISIC ACID ON PHOTOSYNTHETIC AND ANTIOXIDANT METABOLISM IN SEEDLINGS OF Calophyllum brasiliense (CAMBESS.) by Lucas Coutinho Reis (6511265)

“…The decrease in stomatal conductance was accompanied by a decrease in photosynthetic and transpiration rates, but seedlings treated with 10 µM ABA presented a higher photosynthetic rate than the remaining treatments under water deficit. …”

Muscle fiber CSAs of the soleus and EDL muscles in the GH-administered SDRs treated with dexamethasone, BCAA or both. by Hikaru Nishida (757003)

“…Dex-treated group. D. Dex elicited a decrease in the CSAs of the EDL muscles in the GH-treated SDRs. …”

Data_Sheet_1_Enhancement of Cellulase Production in Trichoderma reesei via Disruption of Multiple Protease Genes Identified by Comparative Secretomics.docx by Yuanchao Qian (3433313)

“…Furthermore, three target proteases (tre81070, tre120998, and tre123234) were simultaneously deleted by one-step genetic transformation. The triple deletion strain ΔP70 showed a 78% decrease in protease activity and a six-fold increase in cellulase activity at late fermentation stages. …”