Effects of Cotadutide on Metabolic and Hepatic Parameters in Adults with Overweight or Obesity and Type 2 Diabetes Mellitus: A 54-Week Randomized Phase 2b Study by Rajaa Nahra (10359535)

“…<p><b>Research Design and Methods:</b> In this phase 2b study, 834 adults with BMI ≥25kg/m² and type 2 diabetes inadequately controlled with metformin (glycated hemoglobin A1c [HbA1c] of 7.0%─10.5% [53─91 mmol/mol]) were randomized to double-blind cotadutide 100µg (n=100), 200µg (n=256), or 300µg (n=256), placebo (n=110), or open-label liraglutide 1.8mg (n=110), all administered subcutaneously (NCT03235050). …”

Table_1_Metabolites changes of a low-temperature and low-salt fermented Chinese kohlrabi during fermentation based on non-targeted metabolomic analysis.DOCX by Zhiping Zhao (779373)

“…<p>A low-temperature and low-salt industrially fermented Chinese kohlrabi (LSCK) was developed in this study, with the salt usage decreased by approximately 70% compared to the traditional high-salt fermented Chinese kohlrabi (HSCK). …”

Refractive Profiles in Children Receiving School-Based Eye Exams Following Vision Screening from a Large School-Based Vision Program in 2016 to 2022 by Andrew M. Nguyen (20176426)

“…Main outcomes included any refractive error (at least −0.50D myopia, +0.50 hyperopia, 1.00D astigmatism, or 1.00D anisometropia), clinically significant refractive error (CSRE; more severe refractive error with decreased vision), and refractive amblyopia risk (RAR). …”

Table2_A novel 3D biofabrication strategy to improve cell proliferation and differentiation of human Wharton’s jelly mesenchymal stromal cells for cell therapy and tissue engineeri... by Cristina Blanco-Elices (11563117)

“…Instead, the 3D system retained the expression of typical phenotypic markers of HWJSC, including CD73, CD90, CD105, NANOG and OCT4, and biosynthesis markers such as types-I and IV collagens, with significant increase of some of these markers, especially in the FA100 group. Finally, our analysis of 8 cell signaling molecules revealed a significant decrease of GM-CSF, IFN-g, IL2, IL4, IL6, IL8, and TNFα, suggesting that the 3D culture system did not induce the expression of pro-inflammatory molecules.…”

Table1_A novel 3D biofabrication strategy to improve cell proliferation and differentiation of human Wharton’s jelly mesenchymal stromal cells for cell therapy and tissue engineeri... by Cristina Blanco-Elices (11563117)

“…Instead, the 3D system retained the expression of typical phenotypic markers of HWJSC, including CD73, CD90, CD105, NANOG and OCT4, and biosynthesis markers such as types-I and IV collagens, with significant increase of some of these markers, especially in the FA100 group. Finally, our analysis of 8 cell signaling molecules revealed a significant decrease of GM-CSF, IFN-g, IL2, IL4, IL6, IL8, and TNFα, suggesting that the 3D culture system did not induce the expression of pro-inflammatory molecules.…”

Presentation_1_Development of a Novel Assay Based on Plant-Produced Infectious Bursal Disease Virus VP3 for the Differentiation of Infected From Vaccinated Animals.PPTX by Alessio Bortolami (8737425)

“…The His-VP3 ELISA was validated with a panel of 180 reference sera and demonstrated to have 100% sensitivity (95% CI: 94.7–100.0) and 94.17% specificity (95% CI: 88.4–97.6). …”

Comparisons of GnRH antagonist protocol versus GnRH agonist long protocol in patients with normal ovarian reserve: A systematic review and meta-analysis by Ruolin Wang (1556374)

“…</p><p>Conclusion</p><p>GnRH-ant protocol substantially decreased the incidence of OHSS without influencing the pregnancy rate and live birth rate compared to GnRH-a long protocol among patients with normal ovarian reserve.…”

Supplementary Material for: Effects of Weighted Hula-Hooping Compared to Walking on Abdominal Fat, Trunk Muscularity, and Metabolic Parameters in Overweight Subjects: A Randomized... by Lahelma M. (6830396)

“…WALK but not HULA significantly lowered systolic blood pressure and increased HDL cholesterol while HULA significantly decreased LDL cholesterol. <b><i>Conclusions:</i></b> Hula-hooping with a weighted hula-hoop can be used to decrease abdominal fat % and increase trunk muscle mass in overweight subjects. …”

Table 1_Global burden of childhood otitis media attributable to secondhand smoke from 1990 to 2021: a systematic analysis of the global burden of disease study 2021.docx by Bei Li (90587)

“…</p>Results<p>The global YLDs due to childhood otitis media attributable to SHS decreased by 17.65% in 1990–2021. The ASYR decreased by 28.78%, from 5.49 [95% uncertainty interval (UI): 2.38–9.9] per 100,000 to 3.91 (95% UI: 1.66–7.23) per 100,000. …”

DataSheet3_“Tranq-dope” overdose and mortality: lethality induced by fentanyl and xylazine.DOCX by Mark A. Smith (21079)

“…Notably, a nonlethal dose of xylazine (100 mg/kg) produced an approximately 100-fold decrease in the estimated LD₅₀ for fentanyl. …”

DataSheet2_“Tranq-dope” overdose and mortality: lethality induced by fentanyl and xylazine.DOCX by Mark A. Smith (21079)

“…Notably, a nonlethal dose of xylazine (100 mg/kg) produced an approximately 100-fold decrease in the estimated LD₅₀ for fentanyl. …”

DataSheet1_“Tranq-dope” overdose and mortality: lethality induced by fentanyl and xylazine.DOCX by Mark A. Smith (21079)

“…Notably, a nonlethal dose of xylazine (100 mg/kg) produced an approximately 100-fold decrease in the estimated LD₅₀ for fentanyl. …”

Data_Sheet_1_Differential Inhibition of Platelet Reactivity by Dual Therapy With Aspirin and Low-Dose Rivaroxaban in Peripheral Arterial Disease: A Pilot Study.pdf by Kerstin Jurk (755323)

“…ASA plus rivaroxaban treatment resulted in a significantly decreased thrombin peak in PRP for two triggers, namely, low concentration of tissue factor (TF) and thrombin, compared to ASA monotherapy. …”

Correlation between fat fraction and M2BPGi. by Eun-Hee Nah (11751972)

“…<div><p>Background</p><p>A healthy lifestyle is the most important method for managing nonalcoholic fatty liver disease (NAFLD). …”

CONSORT flow diagram. by Eun-Hee Nah (11751972)

“…<div><p>Background</p><p>A healthy lifestyle is the most important method for managing nonalcoholic fatty liver disease (NAFLD). …”

Luciferase activity and S/MAR MCs are slowly lost over time in labeled cell populations. by John A. Ronald (451321)

“…All clones showed a trend (p = 0.18) towards decreased normalized luciferase expression over long periods of time in culture. …”

<i>Ssdp</i> influences head and wing development. by Safa Salim (9186786)

“…Vertical white dashed line represents the width measurement. Scale bar = 100 μm in the immunofluorescence images. In scatter plots, each dot represents the mean value for a single wing disc. …”

Data_Sheet_1_Increased Expression of 9-Cis-Epoxycarotenoid Dioxygenase, PtNCED1, Associated With Inhibited Seed Germination in a Terrestrial Orchid, Phaius tankervilliae.PDF by Yung-I. Lee (5521739)

“…After 90 DAP, seed maturation was accompanied by a decrease in water content and a concomitant increase in ABA content and PtNCED1 mRNA level along with a marked decrease in germination percentage. …”

Data_Sheet_1_Introducing a Novel Approach for Evaluation and Monitoring of Brain Health Across Life Span Using Direct Non-invasive Brain Network Electrophysiology.docx by Noa Zifman (7357349)

“…MD patients display a pronounced decrease in global and inter-hemispheric frontal connectivity compared to healthy controls. …”

Data_Sheet_2_Increased Expression of 9-Cis-Epoxycarotenoid Dioxygenase, PtNCED1, Associated With Inhibited Seed Germination in a Terrestrial Orchid, Phaius tankervilliae.PDF by Yung-I. Lee (5521739)

“…After 90 DAP, seed maturation was accompanied by a decrease in water content and a concomitant increase in ABA content and PtNCED1 mRNA level along with a marked decrease in germination percentage. …”