Lucanthone promotes APE1 cleavage in presence of protease inhibitor. by Mamta D. Naidu (205011)

“…An arrow indicates the corresponding increase in APE1 25 kDa fragment in last two lanes with a decrease in 35.5 kDa APE1 protein.</p>…”

Validation of target gene knockdown at mRNA and protein levels. by Rajshekhar Y. Gaji (417441)

“…<p>A. The percent decrease in mRNA levels of target genes transfected with gene-specific siRNA were determined using q-RT PCR 72 h post-transfection. …”

Immmocytochemistry of DMT1−IRE, DMT1+IRE, Fpn1 and TfR1 proteins in cortical neurons. by Fang Du (232423)

“…<p>Cells were treated with L-DOPA (0, 1, 5, 10, 100, 200 µM) in DMEM+5%FBS for 16 hours and then immunostained for DMT1−IRE (A), DMT1+IRE (B), Fpn1 (C) or TfR1 (D) antibodies. …”

Table1_Facing the Challenges of Developing Fair Risk Scoring Models.pdf by Gero Szepannek (11564443)

“…Regulatory requirements as given by the Basel Committee on Banking Supervision (BCBS) or the EU data protection regulations have led to an increasing interest and research activity on understanding black box machine learning models by means of explainable machine learning. Even though this is a step into a right direction, such methods are not able to guarantee for a fair scoring as machine learning models are not necessarily unbiased and may discriminate with respect to certain subpopulations such as a particular race, gender, or sexual orientation—even if the variable itself is not used for modeling. …”

DataSheet1_Facing the Challenges of Developing Fair Risk Scoring Models.ZIP by Gero Szepannek (11564443)

“…Regulatory requirements as given by the Basel Committee on Banking Supervision (BCBS) or the EU data protection regulations have led to an increasing interest and research activity on understanding black box machine learning models by means of explainable machine learning. Even though this is a step into a right direction, such methods are not able to guarantee for a fair scoring as machine learning models are not necessarily unbiased and may discriminate with respect to certain subpopulations such as a particular race, gender, or sexual orientation—even if the variable itself is not used for modeling. …”

Image_1_EGTA Can Inhibit Vesicular Release in the Nanodomain of Single Ca2+ Channels.JPEG by Yukihiro Nakamura (735502)

“…In proximity to a channel, the vesicular sensor is often saturated for a long voltage step, but not for a brief Ca²⁺ influx typically evoked by an action potential. …”

Transcriptional and Proteomic Analysis of the <em>Aspergillus fumigatus ΔprtT</em> Protease-Deficient Mutant by Shelly Hagag (171495)

“…Penetration of the pulmonary epithelium is a key step in the infectious process. <em>A. fumigatus</em> produces extracellular proteases to degrade the host structural barriers. …”

Single neuron preferences. by Simon Nougaret (17980269)

“…(C) Average response for each run of 3 subpopulations of neurons: all the neurons that respond to the appearance of the scene (left), and among these, neurons that prefer the first run with an increase in firing rate (center), and neurons that prefer the first run with a decrease in firing rate (right). Neural activity is aligned to the presentation of the scene (start of the Delay epoch), binned in a 200-ms window with a 25-ms step between each point, and normalized for each neuron by subtracting the mean activity and dividing by the standard deviation both calculated in a baseline period (−400 ms until the appearance of the scene). n = number of neurons. …”

Fitness and distribution of cell types. by Joshua R. Christie (725052)

“…The decrease in heteroplasmy in <i>B</i>₁<i>B</i>₂ cells between generations 0–100 is an artifact of introducing <i>U</i>₁ at a frequency of 0.01 (the influx of <i>U</i>₁ gametes homoplasmic for the wild type haplotype converts some heteroplasmic <i>B</i>₁ and <i>B</i>₂ gametes into homoplasmic gametes, which increases the proportion of homoplasmic <i>B</i>₁<i>B</i>₂ cells). …”

Evolution of active membrane properties over time in iPSC-derived neurons plated on POL. by Deborah Prè (5659969)

“…<p>A) Representative traces of voltage clamp recordings showing fast inward currents followed by long-lasting outward currents in a cell at day 55, due to voltage steps in 10 mV increments (shown in the upper panel). …”

TSS-targeted siRNA abolishes the heparanase expression in cancer cells. by Guosong Jiang (182435)

“…The symbols (# and Δ) indicate a significant decrease from untransfected control (mock) and a significant increase from pGL3/Basic, respectively.…”

Presentation_2_Transcriptional Regulation of Stearoyl-Acyl Carrier Protein Desaturase Genes in Response to Abiotic Stresses Leads to Changes in the Unsaturated Fatty Acids Composit... by M. Luisa Hernández (60159)

“…In addition, darkness caused the down-regulation of SAD genes transcripts, together with a decrease in the UFA content of chloroplast lipids. …”

Two Glycosylation Sites in H5N1 Influenza Virus Hemagglutinin That Affect Binding Preference by Computer-Based Analysis by Wentian Chen (125316)

“…The binding of hemagglutinin (HA) on the viral surface to host sialic acid (SA) receptors is a requisite step in the infection process. Phylogenetic analysis reveals that H5N1 viruses can be divided into 10 clades based on their HA sequences, with most human IVs centered from clade 1 and clade 2.1 to clade 2.3. …”

Presentation_1_Randomized Controlled Trial of Modified Nasobiliary Fixation and Drainage Technique.PPTX by Na Mi (1592458)

“…The modified “tube-nose-ear” three-step technique was performed after surgery. The clinical efficacy of a modified nasobiliary fixation and drainage technique was evaluated and compared between the test group and the control group.…”

Presentation_1_Transcriptional Regulation of Stearoyl-Acyl Carrier Protein Desaturase Genes in Response to Abiotic Stresses Leads to Changes in the Unsaturated Fatty Acids Composit... by M. Luisa Hernández (60159)

“…In addition, darkness caused the down-regulation of SAD genes transcripts, together with a decrease in the UFA content of chloroplast lipids. …”

Met-depleted mosquitoes exhibit metabolic defects. by Yuan Hou (767606)

“…<p>(A) A decrease in the glycogen levels was observed in Met-depleted adult female mosquitoes, as measured by colorimetry (<i>left</i>) and PAS staining (<i>right</i>). …”

Revealing Cooperation between Knotted Conformation and Dimerization in Protein Stabilization by Molecular Dynamics Simulations by Yan Xu (14594)

“…In addition to the knotted conformation, dimerization further improves the protein stability by restricting the α1−α5 separation, which is defined as a leading step for protein unfolding. These results provide important insights into the structure–function relationship of dimerization in knotted proteins.…”

Revealing Cooperation between Knotted Conformation and Dimerization in Protein Stabilization by Molecular Dynamics Simulations by Yan Xu (14594)

“…In addition to the knotted conformation, dimerization further improves the protein stability by restricting the α1−α5 separation, which is defined as a leading step for protein unfolding. These results provide important insights into the structure–function relationship of dimerization in knotted proteins.…”

Intermolecular Failure of L-type Ca²⁺ Channel and Ryanodine Receptor Signaling in Hypertrophy by Ming Xu (151206)

“…<div><p>Pressure overload–induced hypertrophy is a key step leading to heart failure. The Ca²⁺-induced Ca²⁺ release (CICR) process that governs cardiac contractility is defective in hypertrophy/heart failure, but the molecular mechanisms remain elusive. …”

Fis binding site modifications, Langevin dynamics simulations of DNA breathing, and EMSA experiments, the first set. by Kristy Nowak-Lovato (101951)

“…<p>(A) Langevin dynamics simulations demonstrating suppressed local DNA breathing dynamics in the FIS1S sequence (compare to FIS1 in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002881#pcbi-1002881-g002" target="_blank">Figure 2</a>). …”