Secreted Amyloid Precursor Protein β and Secreted Amyloid Precursor Protein α Induce Axon Outgrowth In Vitro through Egr1 Signaling Pathway by Stéphanie Chasseigneaux (231744)

“…</p> <h3>Methodology/Principal Findings</h3><p>Final concentrations of 50 to 150 nM bacterial recombinant sAPPα or sAPPβ added to primary neuronal cultures after 1 day in vitro decreased cell adhesion 24 hours later and primary dendrite length 96 hours later. 150 nM sAPPα and sAPPβ induced a similar increase of axon outgrowth, although this increase was already significant at 100 nM sAPPα. …”

ErbB signaling is implicated in generation of neurons and mitoses in the sub-ventricular zone. by Tomomi Sato (301255)

“…Dotted circle, OT. Scale bar, 100 μm. <b>B</b>. Quantification of <i>pou4f1-hsp70l</i>:GFP intensity in the OT for the experiment shown in A (mean ± s.e.m.; **<i>P</i> < 0.01, ***<i>P</i> < 0.001; n = 8, 10, 16 for AG1478, AG43, DMSO, respectively). …”

DAAP1 depletion results in reduced attachment. by Melissa C. Steele-Ogus (12295373)

“…Unattached cells had a greater decrease in DAAP1 expression (38% ± 6) than attached cells (23% ± 2). …”

Soluble klotho blocks DAG stimulation of exocytotic insertion of pre-docked TRPC6 vesicles. by Jian Xie (629484)

“…<p>(A, B) Tetanus toxin (TTX) acts on synaptobrevin (“Sb2” for synaptobrevin-2) to decrease surface expression of TRPC6 channels. …”

Temporal evolution of the dynamic cell compression within Matrigel-coated micro-piston devices. by Sevgi Onal (10871856)

“…<p>Time-lapse live cell imaging with 100 ms per frame was recorded for ladder pressure increase from 0 kPa up to 15.6 kPa and a short cycle at 15.6 kPa with gradual increase (from 0 kPa to 15.6 kPa) and decrease (from 15.6 kPa to 0 kPa) in 30 s for each. …”

Changes in the Bacterial Community Structure of Remediated Anthracene-Contaminated Soils by Laura Delgado-Balbuena (3211080)

“…On the one hand, application of earthworms removed most of the contaminant from the arable soil and had a strong effect on the bacterial community structure, i.e. a decrease in the relative abundance of the Acidobacteria, Chloroflexi and Gemmatimonadetes, and an increase in that of the Proteobacteria compared to the unamended soil. …”

Quantitative image analysis of ovaries from <i>mir-202 -/-</i> juvenile females. by Stéphanie Gay (5733569)

“…The number of small follicles (50–100 μm) is significantly higher compared to wild-type, while the number of follicles in the larger diameter class (200–350 μm) tends to decrease. …”

Caspase-8 activity modulation. by Eva Capdevila-Busquets (683895)

“…Overexpression of PSMC3IP or EPSTI1 in TRAIL-treated MDA-MB-231 <b>(A)</b> and MCF-7 cells <b>(B)</b> decrease caspase-8 activity based on the MYC-tag empty transfection vector (Vector) as control. …”

Conceptual view of the generator function. by Gregory J. Gerling (422901)

“…Then, in three cases with inputs of step stresses, (B) a single step increase in stress σ1 evokes current output I1, which is the sum of slowly inactivating current ISI and rapidly inactivating current IRI, (C) three sequentially delivered step stresses show that current decays but builds upon the prior magnitude, and (D) a single step decrease in stress from σn to σn+1 evokes an immediate decrease in current followed by a slower decay. …”

GlVps depletion affects AcPh localization and activity. by Maria R. Rivero (141332)

“…The graph on the left shows the quantitative fluorescent measurements of ELF97 (acid phosphatase activity). A significant decrease in mean fluorescence in AS cells is observed when compared with Ctrol cells (*p<0,0001). …”

<i>Mecp2</i> deficient neurons and astroglia cells have significantly more chromocenters than wild type cells. by Bianca Bertulat (126768)

“…All analyzed samples show a highly significant (p<0.0001) difference of mean values. …”

Effect of CPP (Light) on GPDH activity in 3T3-L1 preadipocytes. by Kasumi Fujita (10271129)

“…<p>The activity of GPDH was calculated using the extinction coefficient of NADH, 6.22 mM^-1 cm^-1, and was calculated based on the decrease in NADH every 3 min. Enzyme activity is expressed as a value relative to the control (100%). …”

Reconsolidation and extinction after different strengths of training. by Remus Osan (3639754)

“…Bars indicate freezing in vehicle (dark blue) and anisomycin (light blue) groups before (left set) and after (right set) reexposure with <i>t</i> = 4 (mean ± S.E.M. of 100 simulations). As occurs in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023113#pone-0023113-g003" target="_blank">Figure 3C</a>, freezing is decreased by anisomycin administration, indicating reconsolidation blockade. …”

One-way sensitivity analysis to all model parameters. by Anna Miquel-Cases (2635486)

“…The NMB remained cost-effective at all parameters values tested, except at specificity of 55% and sensitivity of 100%, were the NMB became negative. Furthermore, an increase in the proportion of relapses and deaths in the conventional-NACT strategy, an increase in the costs of the R health-state and a decrease in the costs of NX markedly increased cost-effectiveness.…”

Fig 2 - by Nathalie Lavenne-Collot (11262998)

“…</p><p></p><p></p><p>- When both sides are at 100%, the light intensity is progressively decreased in 10% steps on the HC’s side, while it remains at 100% on the AN patient’s side.…”

Color space representation across different CNN layers and different CNN architectures. by JohnMark Taylor (8329326)

“…The averaged correlation over all objects for each layer is plotted in a line graph on the right of each scenario. In the first scenario, the color space structure within each object differs substantially across processing, resulting in a large decrease in correlation across layers. …”

Dissecting Variation in Biomass Conversion Factors across China’s Forests: Implications for Biomass and Carbon Accounting by Yunjian Luo (550803)

“…Moreover, stronger climatic effects were found on BCFs for functional components (i.e. branch, foliage and root) than BCFs for combined components (i.e. aboveground section and whole trees). A general trend for BCFs was observed to decrease and then increase from low to high soil fertility. …”

Datasheet1_Outcomes among patients undergoing transcatheter aortic valve replacement with very low baseline gradients.docx by Faisal Rahman (11048519)

“…Background<p>While there is evidence that patients with low-flow, low-gradient aortic stenosis (AS) benefit from transcatheter aortic valve replacement (TAVR), data are lacking regarding outcomes of patients with a very low gradient (VLG).</p>Methods<p>In this retrospective, single-center study of patients with severe AS who underwent TAVR, three groups were defined using baseline mean aortic valve gradient: VLG (≤25 mmHg), low gradient (LG, 26–39 mmHg), and high gradient (HG, ≥40 mmHg). …”

Multiple modes of modulation of PC simple spikes during light activation of ChR2 specifically expressed in GCs. Light activation of GCs results in inhibition and/or activation of P... by Wolfgang Kruse (619565)

“…Laser power was set to 10 mW, resulting in 2.5 mW in front of light fiber. (E) Mean increase of simple spike rate from 13 PCs showing excitation during light application and mean decrease of activity of 12 PCs showing inhibition during light application. …”

Effects of adenosine receptor-specific antagonists on responses to hypoxia at E9.5 and E12.5. by Daniela L. Buscariollo (140729)

“…<p>A and B: Specimens were treated with DPCPX, an A1AR-specific antagonist at 10 nM (A: E9.5, n = 15; B: E12.5, n = 23), SCH-58261, an A2aAR-specific antagonist at 100 nM (A: E9.5, n = 15; B: E12.5, n = 19), or vehicle (A: E9.5, n = 27; B: E12.5, n = 42) at 15 min (arrows), and exposed to hypoxia (gray boxes). …”