Early blockade of CB1 and/or CB2 receptors reduces the density of serotonergic fibres below the lesion site. by Angel Arevalo-Martin (298990)

“…(E) Quantification of the area occupied by serotonin shows a significant decrease in AM630- and AM281/AM630-treated rats and a strong trend to decrease in AM281-treated rats, that is close to statistical significance (p = 0.06). …”

Effects of variation in D1R-sensitivity on the WM-robustness in terms of signal-to-noise ratio (SNR). by Melissa Reneaux (833810)

“…<p>Similar to the PB, increase in <i>D</i>1<i>R</i>_<i>sens</i> causes a consistent decrease in the SNR of any individual level of sustained activity either sampled from the pre-peak (A) or from the post-peak (B) set of the modulation profile of cortical sustained <i>a</i>_<i>PN</i> activity. …”

C1 shows similar results on macrophages as for microglia and does not interfere with cell activity, proliferation, and cell death are not affected in non-stimulated conditions. by Philipp Jordan (9364068)

“…Treatment with DMSO did not show a significant decrease. <b>e)</b> When stimulated with 100 μg/mL PolyIC for 24 hours using the same protocol as referred above the cells undergo a reduction of metabolic activity after treatment with 0.025 μM C1 compared to DMSO stimulation (p = 0.0053) and the positive control (p = 0.0138). …”

Supplementary file 1_Global burden and trends of adverse effects of medical treatment, 1990–2021: an analysis from the global burden of disease study 2021.docx by Keqing Zhang (326894)

“…By 2036, it is forecast that ASIR will decrease to 72.33 (19.40–125.27) per 100,000 persons-year, and ASDR will decrease to 40.98 (21.52–60.43) per 100,000 persons-year.…”

Graphic summary of the experimental design. by Tainá Rocha de Almeida (8207727)

“…Fish sampling was performed at T0, T31, T87, T154 and T253 days after the beginning of the photophase initial decrease (induction of the reproductive cycle). For each sampling point, sexual steroids and Vitellogenin levels were measured in the plasma and a histological follow up of the oogenesis progression was performed. …”

EWS results for the prevalence of the Alpha-like pathogen show successful anticipation of the epidemic transition. by Joshua Looker (21390948)

“…<p>Columns show proportion infectious over time, effective reproduction number, variance between the mean-detrended simulations and time-of-detection distribution for the 10,000 simulations run for each of the four modelling scenarios (rows, constant , increasing , decreasing and a step-decrease in ) for the Alpha-like pathogen.…”

HIV knowledge and its correlation with the Undetectable = Untransmittable slogan in Brazil by Rayane C. Ferreira (13936302)

“…<div><p>ABSTRACT Knowledge about HIV transmission and prevention is a necessary step for adopting preventive behaviors. …”

Influences of stocking density and dietary probiotic supplementation on growing Japanese quail performance by KHALID M. MAHROSE (6572441)

“…Increasing level of probiotic up to 0.04 g/kg led to a significant decrease in dressing percentage by about 2.7 % compared to the control. …”

Curation of heavy metal corpus validates assigned DRS. by Allan Peter Davis (121500)

“…There is a progressive decrease in the percentage of curated articles with DRS <100. …”

Fluorescence intensity quantification of O4 and MBP and immunohistological assessment of oligodendrocyte markers. by Georgia Panagiotakos (76482)

“…At 6 months post radiation, a spike in O4 levels is followed by a significant decrease that persists until one year and thereafter. …”

CLINICAL AND ECONOMIC IMPACT OF GENETIC AND NON-GENETIC FACTORS ON INR NORMALIZATION IN PRE-OPERATIVE MANAGEMENT OF WARFARIN PATIENTS by ELJILANY, ISLAM AHMED SAYED AHMED

“…To optimize the period of preprocedural warfarin interruption to decrease the incidence of bleeding in case of bridging and the incidence of thromboembolism in case of non-bridging, a study was conducted to determine the influence of CYP2C9, VKORC1, CYP4F2, FII, and FVII genetic polymorphisms and non-genetic factors on INR decline in a cohort of Arabs undergoing a procedure that requires warfarin interruption and developing an algorithm to tailor the duration of warfarin interruption before the procedure. …”
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Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF-5 by Ken-ichi Fujita (83343)

“…Total RNA was extracted and mRNA levels of M-CSF were determined using real-time RT-PCR. Data are shown as means ± SD based on 5 independent experiments. Number signs and asterisks indicate significant changes (< 0.005) compared to untreated cells and Wnt3a-treated cells, respectively. , Dkk1 restores Wnt3a-dependent decrease in M-CSF protein secreted into the extracellular milieu. …”

Proposed metabolic framework for taxane biosynthesis in the <i>Taxus</i> root. by Da Cheng Hao (216777)

“…<p>The committed step of Taxol (paclitaxel) biosynthesis is catalyzed by taxa-4(5),11(12)-diene synthase (TS), a diterpene cyclase responsible for transforming the ubiquitous isoprenoid intermediate geranylgeranyl diphosphate (GGPP) to the parent olefin with a taxane skeleton. …”

Potential mechanisms. by Iwan Zimmermann (117942)

“…Channel gating (described by the efficacy equilibrium constant <i>E</i>) is impaired when the channel is bound to divalent ions (yellow circles, <i>E</i>_Ca²⁺). The decrease in agonist efficacy is likely to be due to a change in the rate of opening, as shown by the size of the arrows in the last step of the reaction. …”

Effects of administration regimen on antitumor activity, TK activity and viral replication. by Daniel Abate-Daga (200715)

“…Group A received 4 doses of 2×10¹⁰ vp ICOVIR5-TK-L on days 0, 1, 7 and 8, and 6 ip doses of 100 mg/kg GCV on days 4, 5, 6, 11, 12 and 13. …”

Combination effect of bradycardia, ApoE4 allele and increased vessel stiffness. by Christina Rose Kyrtsos (810935)

“…There was a small decrease in the number of neurons at the final simulation endpoint (<10%). …”

RS modifies the BRL effects in RC cell population cultures. by Yuji Yoshiko (245190)

“…<p>Cells in osteogenic medium were chronically treated with or without BRL in combination with or without RS or fenofibrate for 14 days. (A and B) A combination of 100 nM BRL and 1–2.5% RS elicits a reciprocal increase in adipocytes (A) and decrease in bone nodules (B). …”

Data_Sheet_1_Dynamic patterns of postprandial metabolic responses to three dietary challenges.pdf by Patrick Weinisch (13848769)

“…We used fuzzy c-means clustering to group these metabolites into eight clusters based on commonalities of their dynamic response patterns, with each cluster following one of four primary response patterns: (i) “decrease-increase” (valley-like) with fatty acids and acylcarnitines indicating the suppression of lipolysis, (ii) “increase-decrease” (mountain-like) including a cluster of conjugated bile acids and the glucose/insulin cluster, (iii) “steady decrease” with metabolites reflecting a carryover from meals prior to the study, and (iv) “mixed” decreasing after the glucose challenge and increasing otherwise. …”

Table_1_Production, Storage Stability, and Susceptibility Testing of Reuterin and Its Impact on the Murine Fecal Microbiome and Volatile Organic Compound Profile.docx by Christoph Castellani (5940710)

“…</p><p>Results: The supernatant contained 13.4 g/L reuterin (3-hydroxypropionaldehyde; 3-HPA). 3-HPA content remained stable at −20°C for 35 days followed by a slow decrease of its concentration. Repeated freezing/thawing caused a slow 3-HPA decrease. …”

Image_1_Production, Storage Stability, and Susceptibility Testing of Reuterin and Its Impact on the Murine Fecal Microbiome and Volatile Organic Compound Profile.pdf by Christoph Castellani (5940710)

“…</p><p>Results: The supernatant contained 13.4 g/L reuterin (3-hydroxypropionaldehyde; 3-HPA). 3-HPA content remained stable at −20°C for 35 days followed by a slow decrease of its concentration. Repeated freezing/thawing caused a slow 3-HPA decrease. …”