Revealing Cooperation between Knotted Conformation and Dimerization in Protein Stabilization by Molecular Dynamics Simulations by Yan Xu (14594)

“…In addition to the knotted conformation, dimerization further improves the protein stability by restricting the α1−α5 separation, which is defined as a leading step for protein unfolding. These results provide important insights into the structure–function relationship of dimerization in knotted proteins.…”

Intermolecular Failure of L-type Ca²⁺ Channel and Ryanodine Receptor Signaling in Hypertrophy by Ming Xu (151206)

“…<div><p>Pressure overload–induced hypertrophy is a key step leading to heart failure. The Ca²⁺-induced Ca²⁺ release (CICR) process that governs cardiac contractility is defective in hypertrophy/heart failure, but the molecular mechanisms remain elusive. …”

Lc exerts anti-inflammatory effect on LPS-activated macrophage cell line RAW 264.7. by Zuzana Zakostelska (328326)

“…*P<0.05: the means were compared against a hypothetical mean of 100% by one sample t-test (B) The effect of Lc on NF-κB binding activity in LPS-stimulated RAW 264.7 cells. …”

Cell culture optimization: effect of collagen on chordoma cell growth (Batch 1) by Nindo Punturi (14025993)

“…</b>) U-CH1 cells undergo morphological changes and a decrease in proliferation when grown in the absence of collagen, as compared to U-CH1 cells grown on a collagen-coated surface. …”

Fis binding site modifications, Langevin dynamics simulations of DNA breathing, and EMSA experiments, the first set. by Kristy Nowak-Lovato (101951)

“…<p>(A) Langevin dynamics simulations demonstrating suppressed local DNA breathing dynamics in the FIS1S sequence (compare to FIS1 in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002881#pcbi-1002881-g002" target="_blank">Figure 2</a>). …”

Characteristic plots of directionality. by Stefan Schöneich (359006)

“…Each data point is mean response of 100 stimulus repetitions. Black dots represent data from directional tests. …”

Systematic review of evidence for the impact and effectiveness of the 1-3-7 strategy for malaria elimination by Richard J. Maude (9416228)

“…</p><h2>Conclusion </h2><p dir="ltr">Overall, the 1-3-7 approach was effectively implemented with a concomitant decrease in cases in malaria elimination settings, however, it was not possible to quantify impact as it was not implemented in isolation. …”

Total neutrophil and total macrophage concentrations for inflammatory mediator inhibition by different inhibitor concentrations. by Sridevi Nagaraja (833270)

“…We simulated chronic inflammation by increasing the initial platelet concentration by 100 fold, increasing the macrophage influx rate parameter by 1.5 fold, and simultaneously decreasing the platelet degradation rate parameter by 1.5 fold. …”

FA and glucose oxidations in SCD1-overexpressed cardiac myocytes. by Hiroki Matsui (330019)

“…<p>(A): FA oxidation was significantly increased in rat neonatal cardiac myocytes treated with 100 µM palmitic acid (PA). …”

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…Finally, when the primer had a 3‘-OH, a fluorescence decrease with a rate equal to the rate of nucleotide incorporation was observed with both 0 and +1 position reporters. …”

<em>Bacillus anthracis</em> Interacts with Plasmin(ogen) to Evade C3b-Dependent Innate Immunity by Myung-Chul Chung (226513)

“…PLG-bound spores were capable of exhibiting anti-opsonic properties by cleaving C3b molecules <em>in vitro</em> and in rabbit bronchoalveolar lavage fluid, resulting in a decrease in macrophage phagocytosis. Our findings represent a step forward in understanding the mechanisms involved in the evasion of innate immunity by <em>B. anthracis</em> through recruitment of PLG resulting in the enhancement of anti-complement and anti-opsonization properties of the pathogen.…”

An Inducible Cell-Cell Fusion System with Integrated Ability to Measure the Efficiency and Specificity of HIV-1 Entry Inhibitors by Alon Herschhorn (198447)

“…<div><p>HIV-1 envelope glycoproteins (Envs) mediate virus entry by fusing the viral and target cell membranes, a multi-step process that represents an attractive target for inhibition. …”

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…Finally, when the primer had a 3‘-OH, a fluorescence decrease with a rate equal to the rate of nucleotide incorporation was observed with both 0 and +1 position reporters. …”

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…Finally, when the primer had a 3‘-OH, a fluorescence decrease with a rate equal to the rate of nucleotide incorporation was observed with both 0 and +1 position reporters. …”

RES complex is associated with intron definition and required for zebrafish early embryogenesis by Juan Pablo Fernandez (5478497)

“…<div><p>Pre-mRNA splicing is a critical step of gene expression in eukaryotes. …”

Multistep Interactions between Ibuprofen and Lipid Membranes by Simou Sun (3089832)

“…Ibuprofen (IBU) interacts with phosphatidylcholine membranes in three distinct steps as a function of concentration. In a first step (<10 μM), IBU electrostatically adsorbs to the lipid headgroups and gradually decreases the interfacial potential. …”

Multistep Interactions between Ibuprofen and Lipid Membranes by Simou Sun (3089832)

“…Ibuprofen (IBU) interacts with phosphatidylcholine membranes in three distinct steps as a function of concentration. In a first step (<10 μM), IBU electrostatically adsorbs to the lipid headgroups and gradually decreases the interfacial potential. …”

Multistep Interactions between Ibuprofen and Lipid Membranes by Simou Sun (3089832)

“…Ibuprofen (IBU) interacts with phosphatidylcholine membranes in three distinct steps as a function of concentration. In a first step (<10 μM), IBU electrostatically adsorbs to the lipid headgroups and gradually decreases the interfacial potential. …”

Multistep Interactions between Ibuprofen and Lipid Membranes by Simou Sun (3089832)

“…Ibuprofen (IBU) interacts with phosphatidylcholine membranes in three distinct steps as a function of concentration. In a first step (<10 μM), IBU electrostatically adsorbs to the lipid headgroups and gradually decreases the interfacial potential. …”

Multistep Interactions between Ibuprofen and Lipid Membranes by Simou Sun (3089832)

“…Ibuprofen (IBU) interacts with phosphatidylcholine membranes in three distinct steps as a function of concentration. In a first step (<10 μM), IBU electrostatically adsorbs to the lipid headgroups and gradually decreases the interfacial potential. …”