Image5_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…The 14–22 amide (myr) PKA inhibitor alone elicits ER Ca²⁺ release, and subsequent treatment with D,L-methadone does not cause additional ER Ca²⁺ release, indicating that PKA inhibition is a key step in D,L-methadone-induced ER Ca²⁺ release and can bypass the D,L-methadone-OPRM1-AC-cAMP step. …”

The GTPase RalA Regulates Different Steps of the Secretory Process in Pancreatic β-Cells by Sanda Ljubicic (257524)

“…Silencing of this GTPase in INS-1E cells by RNA interference led to a decrease in secretagogue-induced insulin release. …”

Decreased BK responsiveness of p38 activation is evident in both PS-1 and PS-2 FAD mutant AD fibroblasts. by Graziella Mendonsa (374346)

Image_2_Serum Zinc-α2-Glycoprotein Levels Were Decreased in Patients With Premature Coronary Artery Disease.JPEG by Meijuan Liu (4924417)

“…At the cutoff value of 7.955 μg/mL serum ZAG, the sensitivity and specificity for differentiating patients with PCAD from controls were 50.5 and 78.0%, respectively. The combination of ZAG with other clinical variables including age, gender, BMI, SBP, FBG, TC, HDL-C, Cr, and Urea had significantly improved the diagnosis accuracy with a sensitivity of 82.6%, a specificity of 95.0%, and AUC of 0.957 (95% CI, 0.940–0.975, p < 0.05).…”

Image_1_Serum Zinc-α2-Glycoprotein Levels Were Decreased in Patients With Premature Coronary Artery Disease.JPEG by Meijuan Liu (4924417)

“…At the cutoff value of 7.955 μg/mL serum ZAG, the sensitivity and specificity for differentiating patients with PCAD from controls were 50.5 and 78.0%, respectively. The combination of ZAG with other clinical variables including age, gender, BMI, SBP, FBG, TC, HDL-C, Cr, and Urea had significantly improved the diagnosis accuracy with a sensitivity of 82.6%, a specificity of 95.0%, and AUC of 0.957 (95% CI, 0.940–0.975, p < 0.05).…”

Table_1_Serum Zinc-α2-Glycoprotein Levels Were Decreased in Patients With Premature Coronary Artery Disease.DOCX by Meijuan Liu (4924417)

“…At the cutoff value of 7.955 μg/mL serum ZAG, the sensitivity and specificity for differentiating patients with PCAD from controls were 50.5 and 78.0%, respectively. The combination of ZAG with other clinical variables including age, gender, BMI, SBP, FBG, TC, HDL-C, Cr, and Urea had significantly improved the diagnosis accuracy with a sensitivity of 82.6%, a specificity of 95.0%, and AUC of 0.957 (95% CI, 0.940–0.975, p < 0.05).…”

Stepwise addition of DMSO. by Renquan Ruan (721497)

Overexpression of GFP-tagged ZFP36L2 decreases LHR mRNA endogenously expressed in MLTC-1 cells. by Christopher B. Ball (564991)

Conceptual diagram summarising the three main steps of the analyses. by Nina McLean (4872268)

Lentivirus-mediated FGFR1 overexpression in A549 cells significantly decreased influenza A virus replication. by Xin Liu (43569)

Lead Exposure Inhibits Fracture Healing and Is Associated with Increased Chondrogenesis, Delay in Cartilage Mineralization, and a Decrease in Osteoprogenitor Frequency-5 by Jonathan J. Carmouche (71816)

vFLIP maintains intestinal barrier integrity in a short term model <i>in vivo</i>. by Barbara Ruder (8379354)

A decreased yield of RNP1, RNP2 and RNP5 formation in the presence of protein aGAR1 is counteracted by RNA-S by Bruno Charpentier (9519)

A Bcl-2-BH4 double-glycine variant (I14G/V15G) has a decreased by Giovanni Monaco (452223)

Fig 5 - by Dennis Ochola (11626912)

Comparing the flow distribution within A-V and V-A-V structures derived from the same vascular bed. by Fatemeh Mirzapour-Shafiyi (10981427)

Time concordance metrics for all TFs, pathways as well as genes using both a minimal |logFC| of 0.5 and 1. by Anika Liu (8411805)

Chest radiograph course of a patient in group 3. by Jin Young Kim (271185)

Subjects:

Chest radiograph course of a patient in group 4. by Jin Young Kim (271185)

Subjects:

PPP2R5C HepKD in <i>db/db</i> mouse liver improves insulin sensitivity, decreases hyperglycemia, but worsens the dyslipidemia. by Yong-Sheng Cheng (803758)

“…<p><b>(A)</b> Hyperglycemia in <i>db/db</i> mice is decreased upon hypatocyte-specific PPP2R5C knockdown with adeno-associated virus. …”