p21 is regulated by AR and required for cellular senescence. by Yelena Mirochnik (179447)

“…Tubulin was used as a loading control (A). Note the decrease in Rb phosphorylation and p21 increase in DHT-treated cells at every time point. …”

Inhibition of CICR by ryanodine reduced the sI_AHP amplitude at steady state in RyR3 +/+ and RyR3 −/− mouse CA1 pyramidal neurons. by Angelo Tedoldi (6547616)

“…(<b>H</b>) Time course of the sI_AHP amplitude in the same RyR3 −/− neuron as shown in D-F. (<b>I)</b> Overall decrease in the sI_AHP amplitude summarized in a box-and-whiskers plot, showing comparable reduction by ryanodine in RyR3 +/+ (mean ± SEM: 39.0 ± 6.9%; median = 36.2%, n = 7) and RyR3 −/− neurons (mean ± SEM: 36.9 ± 9.4%; median = 33.4%, n = 5) (P = 0.9).…”

PPARγ-mediated transactivation activity as well as receptor binding activity of falcarindiol. by Atanas G. Atanasov (27419)

“…<p>(<b>A</b>) HEK-293 cells, transiently transfected with a human PPARγ expression plasmid, a luciferase reporter plasmid (tk-PPREx3-luc) and EGFP as internal control, were treated with different concentrations of pioglitazone or falcarindiol (0.1–30 µM) for 18 h. …”

Data_Sheet_1_Where Might We Find Ecologically Intact Communities?.docx by Andrew J. Plumptre (8140635)

“…Additionally, using habitat/density distribution data for 15 large mammals we also make an initial assessment of areas where mammal densities are reduced, showing a further decrease in surface area to 2.8% of the land surface that could be considered functionally intact. …”

Table1_Changes in prenatal testing during the COVID-19 pandemic.docx by Sara C. Handley (10908161)

“…Mean gestational age for second trimester anatomy ultrasounds increased from the pre-pandemic to COVID-19 period (Highmark 19.4 vs. 19.6 weeks; Penn: 20.1 vs. 20.4 weeks; Yale: 18.8 vs. 19.2 weeks, all p < 0.001). There was a detectable decrease in the proportion of patients who completed the anatomy survey <20 weeks' gestation across datasets, which did not persist at <23 weeks' gestation. …”

Table_2_High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension.docx by Yicheng Yang (12319574)

“…</p>Results<p>Finally, a total of 216 patients with PH were included and the medians for betaine plasma levels in the total patients group, low betaine, and high betaine groups were 49.8 (39.0, 68.3) μM, 39.0 (33.5, 44.7) μM, and 68.1 (57.8, 88.7) μM, respectively. …”

Evaluation and application of summary statistic imputation to discover new height-associated loci by Sina Rüeger (606696)

“…For fixed false positive rates of 0.001, 0.01, 0.05, using <i>summary statistics imputation</i> yielded a decrease in statistical power by 9, 43 and 35%, respectively. …”

DataSheet_1_Biophysical contexture of coastal biofilm-sediments varies heterogeneously and seasonally at the centimeter scale across the bed-water interface.docx by Xindi Chen (6485522)

“…The overall EPS secretion in spring and summer was generally at high level than that in autumn and winter, with the maximum value of 5~6 times higher. Interestingly, the stratification of biological and physical properties followed a fixed relationship, where with the decrease of the grain size D₅₀, the EPS content increased exponentially, and this relationship was independent of temporal or spatial variation. …”

Data Sheet 1_25-year trajectories of physical activity and atrial fibrillation risk: results from the ARIC study.docx by Tongxin Wang (2524945)

“…</p>Conclusion<p>Maintaining moderate levels of physical activity is associated with a lower risk of AF, while a decrease in activity from moderate to light levels increases the risk. …”

Table_1_Early apixaban administration considering the size of infarction and functional outcome in acute ischemic stroke.DOCX by Min Hwan Lee (1657279)

“…Early initiation of apixaban was independently associated with favorable outcomes (odds ratio: 2.75, 95% confidence interval: 1.44–5.28, p = 0.002).</p>Conclusion<p>Our findings suggest that early initiation of apixaban, tailored to infarct size, could serve as a viable strategy to enhance functional outcomes. …”

Table_1_Investigating the Association Between the Caecal Microbiomes of Broilers and Campylobacter Burden.DOCX by Ioannis Sakaridis (5246462)

“…There was no clear link between Campylobacter counts and Firmicutes, Bacteroidetes, or Tenericutes levels in the 16S rRNA operational taxonomic unit (OTU)-based analysis of the caecal microbiome, but samples with high Campylobacter counts (>9 log CFU g^-1) contained increased levels of Enterobacteriaceae. A decrease in Lactobacillus abundance in chicken caeca was also associated with high Campylobacter loads. …”

Image_4_Maternal prebiotic supplementation impacts colitis development in offspring mice.TIF by Amélie Lê (14331069)

“…In addition, maternal prebiotic supplementation induced an overabundance of eight bacterial families and a decrease in the butyrate caecal concentration in DSS-treated offspring.…”

Image 3_Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-vil... by Kyosuke Kobayashi (21526655)

“…Regarding cell differentiation, LAB suppressed the downregulation of LGR5, VIL1, LYZ and MUC2 by cytokines. Moreover, they ameliorated reduced mucin 2 protein production and decreased the number of mucin 2-positive cells. …”

Table_1_Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway.XLSX by Phuong Doan (245894)

“…Furthermore, we identified 3,714 genes with significant changes at the transcriptional level in response to THTMP. Further, a transcriptional analysis (RNA-seq) revealed that THTMP targeted the p53 signaling pathway specific genes causing DNA damage and cell cycle arrest at G1/S phase explained by the decrease of cyclin-dependent kinase 1, cyclin A2, cyclin E1 and E2 in glioma cells. …”

Image_2_Monochromatic Blue Light Activates Suprachiasmatic Nucleus Neuronal Activity and Promotes Arousal in Mice Under Sevoflurane Anesthesia.TIF by Daiqiang Liu (9250967)

“…</p><p>Results: Unlike the lack of effect on the induction time, MBL shortened the emergence time and the EEG recordings showed cortical arousal during the recovery period. MBL resulted in a significant decrease in BSR and a marked increase in EEG power at all frequency bands except for the spindle band during 2.5% sevoflurane anesthesia. …”

Image_4_Galantamine ameliorates hyperoxia-induced brain injury in neonatal mice.TIF by Nahla Zaghloul (636747)

“…Treated hyperoxic group showed a significant increase of choline acetyl transferase (ChAT) expression and a decrease of acetyl choline esterase activity, thus increasing acetyl choline levels in hyperoxia environment. …”

Validation of ASEs dysregulated in infected cells. by Simon Boudreault (2480881)

“…The analysis was performed on 16 selected ASEs (Abi1, Cwc22, Eif4a2, Hnrnpa2b1, Il34, Srsf3, Srsf5, Alkbh1, Cdkn2aip, Cflar, Hif1a, Mdm2, Serbp1, Sfswap, Smc2, Tbp). …”

Image_3_Maternal prebiotic supplementation impacts colitis development in offspring mice.TIF by Amélie Lê (14331069)

“…In addition, maternal prebiotic supplementation induced an overabundance of eight bacterial families and a decrease in the butyrate caecal concentration in DSS-treated offspring.…”

Upper-crust thermal evolution of the Patagonian Precordillera basement (Argentina): insights from fission track, (U-Th)/He thermochronology and geodynamic significance by Paulo Marcos (7459064)

“…This first stage might have resulted from coupled tectonothermal processes consisting of extensional faulting and high-temperature gradient. Subsequently, a relatively fast temperature decrease (2.75–5°C/My) for the late Early Cretaceous to Paleocene is likely related to a compressive stage associated with the growth of the early Andean Orogen. …”

High-Pressure Oxidation of an Ammonia–Methanol Mixture: An Experimental and Modeling Study by Haochen Zhan (9584884)

“…Experiments were conducted in a flow reactor at 5.0 MPa between 650 and 1250 K under different equivalence ratios. …”