Table_5_Analysis of the Neuroproteome Associated With Cell Therapy After Intranigral Grafting in a Mouse Model of Parkinson Disease.XLSX by Hassan Dakik (8921816)

“…Protein expression was compared in non-grafted brain to 1 and 7 days after intranigral grafting of E12.5 embryonic ventral mesencephalon (VM). We found a total of 277 deregulated proteins after transplantation, which are enriched for lipid metabolism, oxidative phosphorylation and PD, thus confirming that our animal model is similar to human PD and that the presence of grafted cells modulates the expression of these proteins. …”

Image_5_Analysis of the Neuroproteome Associated With Cell Therapy After Intranigral Grafting in a Mouse Model of Parkinson Disease.TIF by Hassan Dakik (8921816)

“…Protein expression was compared in non-grafted brain to 1 and 7 days after intranigral grafting of E12.5 embryonic ventral mesencephalon (VM). We found a total of 277 deregulated proteins after transplantation, which are enriched for lipid metabolism, oxidative phosphorylation and PD, thus confirming that our animal model is similar to human PD and that the presence of grafted cells modulates the expression of these proteins. …”

Activated CD4+ CD45RO+ memory T-cells decrease secretion of soluble caspase-1 and P2X7R mRNA expression in monocytes leading to a reduced response upon ATP binding. by Vanessa Beynon (153924)

“…A significant decrease of soluble Caspase-1 in the supernatant of cells co-cultured with activated memory T-cells was observed both in the presence and absence of IFNβ; b) intracellular levels of pro-IL-1β measured with an ELISA specific for the immature precursor of IL-1β showed a significant increase in pro-IL-1β levels in the presence of human activated CD4+CD45RO+ memory T-cells (n = 3), cell lysates from adherent monocytes were obtained after removal of non-adherent T-cells after addition of LPS and prior to incubation with ATP c) the ratio of intracellular pro-IL-1β to released soluble Caspase-1 is significantly increased in the presence of human activated CD4+CD45RO+ memory T-cells (n = 3). d) <i>P2X7R</i> mRNA expression in monocytes cultured overnight with activated CD4+CD45RO+ memory T-cells is decreased with and without addition of exogenous IFNβ (n = 3), mRNA was isolated from adherent monocytes after removal of non-adherent T-cells after addition of LPS and prior to incubation with ATP (Data are shown as means ± SD of duplicate cultures; *p<0.05; **p<0.01 employing repeated measures ANOVA with post-hoc Bonferroni adjustment for multiple comparisons to avoid random correlations); e) Ca²⁺-influx measurement in monocytes cultured with activated human CD4+CD45RO+ memory T-cells in the presence of IFNβ demonstrates the absence of slow sustained Ca²⁺-influx mediated by ATP binding to the purinergic P2X7-receptor (representative of 3 independent experiments); f) Annexin V staining of monocytes coincubated with T-cells and stimulated with LPS was measured by flow cytometry (representative flow cytometry histogram of n = 5).…”

Manipulations of DILP5 expression in larval tubules also affect lifespan during stress. by Jeannette A. E. Söderberg (221671)

“…Knockdown by C324/Dilp5-RNAi increased median lifespan by almost 25% (P<0.01 to both controls; Log rank test; n = 30 for the different genotypes) and over expression by C324/UAS-Dilp5 decreased lifespan by the same amount (P<0.001 to both controls; n = 30 for the different genotypes).…”

GhostV2Bottleneck. by Cuiying Yu (18437285)

“…To mitigate these possible hazards and decrease their probability, this study proposes a lightweight object detection method for hazardous chemical vehicles based on the YOLOv7-tiny model.The method first introduces a lightweight feature extraction structure, E-GhostV2 network, into the trunk and neck of the model to achieve effective feature extraction while reducing the burden of the model. …”

<i>Zfp804A</i> mRNA expression in the developing rat brain. by Katja Hvid Hinna (766041)

“…(C) Relative <i>Zfp804A</i> expression within the rat hippocampus. Expression is significantly increased in the adult rat compared to P5 (*<i>P</i><0.05). …”

Experimental setup and spike sorting. by Lear Cohen (15353793)

Table_5_Diversity and function of soybean rhizosphere microbiome under nature farming.xlsx by Dominic V. A. Agyekum (14693605)

Change in influenza vaccination uptake from May 2020 to October 2024 (weighted). by Hannah Melchinger (20234665)

Data referring to Fig 5. by Noemi Sgammeglia (16317431)

Correlations between soil chemical properties. by Fengzhen Fu (17720636)

“…Compared with CK treatment, plant height and aboveground biomass of T increased by 158.73% and 240.13%, respectively; 2) Cellulose and lignin improved soil structure, and soil porosity, and decreased soil compaction (21.95%); 3) Compared with CK treatment, T treatment decreased soil pH by 0.5 units, total salt content decreased by 30.95%, exchangeable Na⁺ decreased by 63.00%, and exchangeable sodium percentage (<i>ESP</i>) decreased by 61.51%. …”

Irradiated mice have a systemic surge in immature myeloid cells that is essential for mitigation. by Ewa D. Micewicz (235071)

Video5.mp4 by Jun Sun (48981)

Chromosome ensemble in the A549 cells. by Xiakun Chu (151393)

Image_5_Brucella abortus BspJ Is a Nucleomodulin That Inhibits Macrophage Apoptosis and Promotes Intracellular Survival of Brucella.JPEG by Zhongchen Ma (9631427)

C4BP binding to <i>N</i>. <i>gonorrhoeae</i> is necessary and sufficient for the serum-mediated decrease in bacterial association with neutrophils. by Lacie M. Werner (14710419)

Data of Fig 5C. by Xianyu Piao (145967)

“…The expression and localization of SjCL1 were analyzed by qRT-PCR, western blotting and immunofluorescence assays. Among these five rSjCLs, only the immunization with rSjCL1 conferred partial protection to the mice against <i>S. japonicum</i> infection, resulting in a reduction in worm burden by 34.9% ~ 38.0% and a decrease of egg burden by 46.2% ~ 48.3%. …”

Image 5_Using sodium glycodeoxycholate to develop a temporary infant-like gut barrier model, in vitro.pdf by Francesca Bietto (21511316)

“…The treatment also reduced the key tight junction protein, occludin, at the cell membrane, and increased acidic mucins and extracellular alkaline phosphatase activity. Additionally, GDC decreased cAMP, suggesting its mechanism of action was via activation of a G-protein coupled receptor. …”

A comparison of therapies with anti-PCSK9 antibodies and small-molecule inhibitors. by Yuri Efremov (11450672)

DataSheet5_Identification of circulating metabolites linked to the risk of breast cancer: a mendelian randomization study.CSV by Xiaosheng Zhu (9101853)