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Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD)
Published 2020“…Wild-type C57BL/6 mice were exposed to 6 months of second-hand smoke in a full-body chamber. Surfactant lipids were decreased by 60% in subjects with COPD. …”
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Table_1_Dimethyl Sulfoxide Decreases Levels of Oxylipin Diols in Mouse Liver.xlsx
Published 2019“…Liver tissue from male mice (C57Bl6/N) that were either untreated or injected with 1% DMSO at 18 weeks of age was analyzed for oxylipin levels using ultrahigh performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). A decrease in oxylipin diols from linoleic acid (LA, C18:2n6), alpha-linolenic acid (ALA, C18:3n3) and docosahexeanoic acid (DHA, C22:6n3) was observed 2 h after injection with DMSO. …”
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Elementary Steps in Olefin Metathesis: Nickelacyclobutanes via Cycloaddition to Nickel Carbenes
Published 2025“…This is the sole example to date of an obervable NiCB generated via cycloaddition, beyond the fluorinated examples. Computations pinpoint a decreased energy barrier to cycloreversion, relative to reductive elimination or β-H elimination, as the core requirement to achieve metathesis. …”
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Enalaprilat and losartan decrease erythroid precursors frequency in cells from patients with polycythemia vera
Published 2023“…After the discovery of a mutation in the Janus kinase 2 (<i>JAK</i>2<sup>V617F</sup>), JAK2 inhibitors have been tested as second-line therapies. …”
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DataSheet2_Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5−/− mice, decreases plasma cholesterol and epididymal fat deposition.pdf
Published 2022“…<p>We previously showed that Fmo5<sup>−/−</sup> mice exhibit a lean phenotype and slower metabolic ageing. …”
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DataSheet1_Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5−/− mice, decreases plasma cholesterol and epididymal fat deposition.PDF
Published 2022“…<p>We previously showed that Fmo5<sup>−/−</sup> mice exhibit a lean phenotype and slower metabolic ageing. …”
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Image1_Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models.jpg
Published 2022“…We also found that the knockdown and knockout (KO) of KIFf5B significantly decreased the tau stability, and overexpression of KIF5B in KIF5B-KO cells significantly increased the expression of phosphorylated and total tau levels. …”