Metallization of a Hypervalent Radical Dimer: Molecular and Band Perspectives by John S. Tse (1321242)

“…Variable pressure and temperature conductivity measurements on the bisthiaselenazolyl radical dimer [<b>1a</b>]₂ have established the presence of a weakly metallic state over the pressure range 5−9 GPa. …”

Passive transfer of humanized anti-NS1 mAb 33D2 into DENV-inoculated mice decreases viral titer and NS1 level in mouse sera. by Sen-Mao Tien (12481273)

Elimination of persistent <i>P</i>. <i>c</i>. <i>chabaudi</i> infection decreases memory T cell numbers in <i>Icos</i>^-/- mice. by Leah E. Latham (8781863)

Relationships between expression of lipogenic transcriptional regulators and liver STAT5b activity status. by Keiyu Oshida (692817)

“…Increase or decrease in gene expression was defined as ≥ 1.5-fold or ≤ -1.5-fold, respectively. …”

Table_2_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.docx by Xiao-yang Gong (13103400)

“…</p>Results<p>To the best to our knowledge, we present for the first time an overview of the genomic mutation spectrum of early-stage laryngeal cancers. A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Image_2_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.tif by Xiao-yang Gong (13103400)

“…</p>Results<p>To the best to our knowledge, we present for the first time an overview of the genomic mutation spectrum of early-stage laryngeal cancers. A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Table_4_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.docx by Xiao-yang Gong (13103400)

“…</p>Results<p>To the best to our knowledge, we present for the first time an overview of the genomic mutation spectrum of early-stage laryngeal cancers. A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Table_1_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.docx by Xiao-yang Gong (13103400)

“…</p>Results<p>To the best to our knowledge, we present for the first time an overview of the genomic mutation spectrum of early-stage laryngeal cancers. A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Image_1_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.tif by Xiao-yang Gong (13103400)

“…</p>Results<p>To the best to our knowledge, we present for the first time an overview of the genomic mutation spectrum of early-stage laryngeal cancers. A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Table_3_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.docx by Xiao-yang Gong (13103400)

“…</p>Results<p>To the best to our knowledge, we present for the first time an overview of the genomic mutation spectrum of early-stage laryngeal cancers. A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Graphic representation of the relation between the mean values of alveolar volume, calculated by the quintile method, and those of the corresponding DLCO, in healthy individuals (p... by Renato Prediletto (86307)

“…</p><p></p> The alveolar volume does not show any remarkable change when related to the expired volume in healthy individuals (only 300 ml), at variance with those of COPD patients. In addition, DLCO decreases by 1.5 mmol/min/mmHg with respect to the slight changes of the alveolar volume in healthy individuals, whereas it increases by less than 1 mmol/min/mmHg for a total increase of 2.5 litres of alveolar volume in COPD patients from TLC to RV.…”

Effect of expressing ^H2F1 WT or Znf5 C2>A2 on the REH2 steady-state abundance. by Vikas Kumar (153353)

“…<p><b>(A)</b> Western blots of extracts with tagged ^H2F1 WT (lanes 1–2) or Z5 C2>A2 (Z5; lanes 3–4). …”

Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture by Pekka Kallunki (398041)

“…MRP2 was induced by 27 compounds followed by MDR1 (16) > BCRP (9) > OCT1 (8) > OATP1B1 (5) > MRP3 (2).</p><p>3. CYP3A4 appeared to be down-regulated (≥2-fold decrease in mRNA expression) by 53 compounds, 10 for CYP2B6, 6 for OCT1, 4 for BCRP, 2 for CYP1A2 and OATP1B1 and 1 for MDR1 and MRP2.…”

CRISPRi knockdown of Lon protease to increase half-life. by Nicholas A. Rossi (3622865)

“…Negative and positive values indicate relative changes in concentration compared to the mean. <b>(B)</b> Analytical solutions for the variability of a protein as a function of differing half-lives. …”

AR-induced downstream signaling cascades were recapitulated in membrane-LRs of HUVECs cells, upon KSHV infection. by Xing Wang (154377)

“…<p>(a, b) PP1-induced decreasing expression of pEphA2 at Ser897 is rescued by DHT treatment upon KSHV infection. …”

Table 1_A national population-based study of mortality and risk factors in COVID-19-hospitalized patients in Spain (2020–2021).docx by José-Manuel Ramos-Rincón (10428656)

“…Hospitalization rates dropped from 697/100,000 people to 411/100,000, and in-hospital mortality (IHM) decreased from 16.2 to 11.5% (adjusted odds ratio [AOR]: 0.71, 95% CI: 0.70–0.73, p < 0.001). …”

Synthesis and Properties of the Heterospin (<i>S</i>₁ = <i>S</i>₂ = ¹/₂) Radical-Ion Salt Bis(mesitylene)molybdenum(I) [1,2,5]Thiadiazol... by Nikolay A. Pushkarevsky (1565458)

“…Low-temperature interaction of [1,2,5]­thiadiazolo­[3,4-<i>c</i>]­[1,2,5]­thiadiazole (<b>1</b>) with MoMes₂ (Mes = mesitylene/1,3,5-trimethylbenzene) in tetrahydrofuran gave the heterospin (<i>S</i>₁ = <i>S</i>₂ = ¹/₂) radical-ion salt [MoMes₂]⁺[<b>1</b>]⁻ (<b>2</b>) whose structure was confirmed by single-crystal X-ray diffraction (XRD). …”

Decreased Caffeine-Induced Locomotor Activity via Microinjection of CART Peptide into the Nucleus Accumbens Is Linked to Inhibition of the pCaMKIIa-D₃R Interaction by Qiang Fu (129583)

“…After repeated oral administration of caffeine (30 mg/kg) for five days, microinjection of CART peptide (0.08 μM/0.5 μl/hemisphere) into the NAc affected locomotor behavior. …”

Table_5_Resistant Potato Starch Alters the Cecal Microbiome and Gene Expression in Mice Fed a Western Diet Based on NHANES Data.xlsx by Allen D. Smith (8798879)

“…To address this, mice were fed a Total Western Diet (TWD) based on National Health and Nutrition Examination Survey (NHANES) data that mimics the macro and micronutrient composition of a typical American diet for 6 weeks and then supplemented with 0, 2, 5, or 10% of the RS2, resistant potato starch (RPS), for an additional 3 weeks. …”

Disorder predictions for the Bex protein family in human: A) Bex1 and Bex2; B) Bex3 and Bex5; C) Bex4. by Eva M. Fernandez (610643)