Development of a Rapidly Dissolvable Oral Pediatric Formulation for Mefloquine Using Liposomes by Wei-Lun Tang (4014314)

“…The dosage form for Mef is mostly available as adult tablets, and thus children under the age of 5 suffer from poor medication adherence. We have developed a stable, rapidly dissolvable, and palatable pediatric formulation for Mef using liposomes composed of 1,2-distearoyl-<i>sn</i>-glycero-3-phosphocholine (DSPC) and cholesterol with a mean diameter of ∼110 nm. …”

QLT-0267 Increases Nuclear Area and Multinucleated Cells in a Concentration-Dependent Manner. by William K. A. Sikkema (574881)

“…The changes in multinucleated cells tracked with changes in size for Y79 cells. A maximum concentration effect was observed at 12.5 µM for both cell lines and a surprising decrease in multinucleated cells was observed at 20 and 25 µM (relative to 12.5 µM). …”

Rad51 paralogs and the risk of unselected breast cancer: A case-control study by Peter Grešner (3533093)

“…In <i>Xrcc3</i>, the ⁴⁵⁴¹A/⁹⁶⁸⁵A haplotype was found to be significantly associated with reduced BrC risk (OR = 0.5; 95% CI: 0.3–0.9; p<0.05). …”

Immunofluorescent staining of TMEM43 and IC disc proteins in HL-1 cells stably expressing wild-type and mutant TMEM43. by Vinayakumar Siragam (455948)

Data_Sheet_1_A Novel CD3G Mutation in a Taiwanese Patient With Normal T Regulatory Function Presenting With the CVID Phenotype Free of Autoimmunity—Analysis of all Genotypes and Ph... by Wen-I Lee (474051)

“…This patient had the common variable immunodeficiency (CVID) phenotype and received regular immunoglobulin infusions over 20-years; he gradually developed nodular regenerative hyperplasia over a 5-year period. Distinct from the previously reported CD3G mutations, which mainly present as autoimmunity, the novel CD3G deletion (c.del213A) in our patient caused an obvious decrease in switched memory B cells and diminished CD40L expression. …”

Table_1_Triglyceride affects the association between estimated glomerular filtration rate and the onset of non-alcoholic fatty liver disease: A second analysis of a Chinese cohort... by Haofei Hu (8534712)

“…Further, compared to non-HTG subjects with eGFR ≥ 116.56 ml/min/1.73 m², participants with HTG and eGFR < 82.88 ml/min/1.73 m² had about a fourfold increase in the risk (HR = 4.852 95% CI: 3.943–5.970) of NAFLD.…”

Impact on child acute malnutrition of integrating a preventive nutrition package into facility-based screening for acute malnutrition during well-baby consultation: A cluster-rando... by Elodie Becquey (3822208)

“…We hypothesized that the integration of a preventive package including age-appropriate behavior change communication (BCC) on nutrition, health, and hygiene practices and a monthly supply of small-quantity lipid-based nutrient supplements (SQ-LNSs) to the monthly screening would increase AM screening and treatment coverage and decrease the incidence and prevalence of AM.…”

STEM: a tool for the analysis of short time series gene expression data-2 by Jason Ernst (24617)

“…The data was sampled at five time points 0 h, .5 h, 3 h, 6 h, and 12 h. The data set was filtered to contain only the 2989 genes with no missing data (though STEM can handle missing data without filtering, see ) that exhibited a .8 log base two fold increase or decrease for at least one time point. …”

Resistive room temperature LPG sensor based on a graphene/CdO nanocomposite by Goutham S.

“…The electrical resistance measurement at a constant bias voltage of 0.5 V. The sensor of type CdO/graphene (1 wt.%) exhibits a sensitivity of 600 ppm of LPG at 27 C. …”
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DataSheet1_Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach.pdf by Punyabhorn Rattanacheeworn (11447329)

“…AUC and C_max GMR (95%CI) of atorvastatin, another CYP3A substrate, was increased 2.14 (1.52–3.02) fold in healthy elderly and 4.15 (2.98–5.79) fold in elderly patients with CKD, indicating decreased CYP3A activity related to ageing. …”

African Swine Fever Virus Uses Macropinocytosis to Enter Host Cells by Elena G. Sánchez (158471)

“…Inhibition of these key regulators of macropinocytosis, as well as treatment with the drug EIPA, results in a considerable decrease in ASFV entry and infection. …”

The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen by Betty Luong (5738027)

“…The accumulation of collagen was accompanied by a strong decrease of the expression and activity of the protease cathepsin B. …”

Effects of mismatched crRNAs on Cas12a-mediated phage defense. by Michael A. Schelling (15295682)

“…<p>(A) Schematic of crRNA expression and processing by FnCas12a and crRNA phage target locations. crRNA mismatches were introduced by mutating individual nucleotides in the spacer sequence. …”

Steady-state fluorescence studies provide additional support to the A region Model 3. by Sylvain Maenner (255271)

“…<p>In (A, B, and C), the binding sites of oligonucleotides P1 to P6 used in the FRET experiments are shown for the three 2-D structures of the A region corresponding to Models 1, 2, and 3. …”

Model response characteristics produced as a result of adjusting AMPA and NMDA conductance levels. by Cal F. Rabang (191595)

“…<p>Y-axis values correspond to AMPA conductance (0 – 20 nS), X-axis values correspond to ratio of NMDA to AMPA conductance (0, .5, 1, 1.5, 2, 2.5, 3). Values of AMPA conductance and NMDA:AMPA ratio chosen for Large and Small IC inputs are identified by a white L and S on the 100 ms color plots, respectively. …”

Lovastatin treatment results in actin disorganization and inhibits VEGF induced rhoA activation. by Tong T. Zhao (361937)

“…<p>A, Actin cytoskeletal organization was visualized using rhodamine-conjugated phalloidin following 24 hr 0.5, 2 and 5 µM lovastatin treatments of HUVEC. …”

PrA conditioning reduced PBMC IP-10 secretion <i>in vitro</i>. by Maomao Zhang (393240)

“…The highest dose induced a significant decrease in viable cell count, therefore, only 5 nM and 20 nM concentrations were used in subsequent experiments. …”

Ligand-dependent stability of a 240 kDa protein can be probed by FASTpp. by David Minde (470117)

“…A gradual decrease in the band intensity at higher temperatures indicates unfolding. …”

A COX inhibitor does not prevent the development of tactile allodynia after nerve injury. by Shigeo Hasegawa (249454)

“…The COX-1 inhibitor SC-560 (20 nmol/10 µl) administered through a catheter whose tip was positioned near the L5 DRG once daily for 14 days did not suppress the development of nerve injury-induced a decrease in the paw withdrawal threshold of tactile stimulation using von Frey filaments. …”

Single Molecule Nanospectroscopy Visualizes Proton-Transfer Processes within a Zeolite Crystal by Zoran Ristanović (1359162)

“…In this work, the Brønsted-acid-catalyzed oligomerization of styrene derivatives was used for the first time as a single molecule probe reaction to study the reactivity of individual zeolite H-ZSM-5 crystals in different zeolite framework, reactant and solvent environments. …”