Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Fig 7 - by B. Ulfhake (6293984)

Fig 8 - by B. Ulfhake (6293984)

Fig 6 - by B. Ulfhake (6293984)

Antibiotic Resistome Changes Associated with Different Types of Corrosion Inhibitors When Chlorine is Used as a Disinfectant by Lee K. Kimbell (21520910)

Fig 12 - by B. Ulfhake (6293984)

Fig 18 - by B. Ulfhake (6293984)

Relationships between stable isotopes and nitrate anomalies. by Antonio Bode (1473376)

Fig 11 - by B. Ulfhake (6293984)

Circadian rhythmicity of in-cage activity of male (upper panel) and female (lower panel) mice at the four sites. by B. Ulfhake (6293984)

Minute-based frontality and latrine positions day-by-day across cage-change cycles. by B. Ulfhake (6293984)

Fig 1 - by B. Ulfhake (6293984)

Boxplots of average NH₃ ppm in cages with four female or four male mice (see key for male and female) across five cage changing cycles at KI, LUMC and UGA. by B. Ulfhake (6293984)

Position of latrine(s). by B. Ulfhake (6293984)

Fig 2 - by B. Ulfhake (6293984)

Response times. by Luke E. Hallum (10428478)

“…<p>(<b>A</b>) CG247X response times. The leftmost gray box (labelled “0%”) encompasses four points showing mean response times for transitions from source luminance = 0% to destination luminances = 25, 50, 75, and 100% (x axis). …”

Bacterial growth load (CFUs) and average of NH₃ ppm across the cage-change cycle in cages changed bi-weekly (filled circles) vs. weekly (open circles). by B. Ulfhake (6293984)