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19861
Table1_Optimizing tacrolimus dosing in Hispanic renal transplant patients: insights from real-world data.DOCX
Published 2024“…The estimated apparent clearance was 13.7 L/h for a typical patient weighing 70 kg and at 30% hematocrit, demonstrating a 40% decrease in clearance compared to other patient populations. …”
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19862
Data_Sheet_1_Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells.PDF
Published 2023“…Analysis of the effect of boldine (25–600 μM) on different types of primary human GBM cells (GBM59, GBM96, and U87-MG) showed a concentration-dependent decrease in GBM cell growth. …”
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19863
Image2_Optimizing tacrolimus dosing in Hispanic renal transplant patients: insights from real-world data.JPEG
Published 2024“…The estimated apparent clearance was 13.7 L/h for a typical patient weighing 70 kg and at 30% hematocrit, demonstrating a 40% decrease in clearance compared to other patient populations. …”
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19864
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19865
Development and Validation of an Immunoassay for Quantification of Topoisomerase I in Solid Tumor Tissues
Published 2012“…Cellular response to Top1 inhibitors is complex, but Top1 target engagement is a necessary first step in this process. This paper reports the development and validation of a quantitative immunoassay for Top1 in tumors.…”
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19866
Glycerol biosynthesis and CO<sub>2</sub> production.
Published 2015“…<p>Glycerol biosynthesis from dihydroxyacetone phosphate is a two-step process. The first step which is catalyzed by the Gpd enzyme, is rate limiting for the production of glycerol. …”
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19867
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19868
The therapeutic effects of human bone marrow-derived mesenchymal stem cells (MSCs) in IL-1RaKO mice.
Published 2018“…Scale bar: 200 μm (50×), 100 μm (100×), and 50 μm (200×). (D) Synovial hyperplasia and cellular infiltrate were each scored on a scale of 0–3. …”
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19869
Increased active Rap1 in Rasa3<sup>−/−</sup> megakaryocytes.
Published 2014“…Two independent experiments (quantification of 50 megakaryocytes per experiment,) with mean ± SEM are presented. …”
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19870
Altered Astrocytic Swelling in the Cortex of α-Syntrophin-Negative GFAP/EGFP Mice
Published 2014“…Similarly, evaluation of relative α changes showed a significantly smaller decrease in α-syntrophin knockout mice only during severe pathological conditions, but not during mild stimuli. …”
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19871
Table1_Baseline Plasma Metabotype Correlates With Direct-Acting Antiviral Therapy Nonresponse for HCV in HIV–HCV Coinfected Patients.XLSX
Published 2022“…Post therapy, 62 plasma metabolites (12 upregulated and 50 downregulated, FC±1.5, p < 0.05) differentiated nonresponders from responders and highlighted a significant increase in the steroid and histidine metabolism and significant decrease in tryptophan metabolism and ascorbate and pyruvate metabolism in the nonresponders. …”
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19872
Partial silencing of GFP requires both EhRNaseIII and ScaAgo1.
Published 2015“…FACS histogram of GFP fluorescence in the indicated strains show a decrease in GFP fluorescence in strain expressing EhRNaseIII using the strong GFP silencing hairpin but only in the strain expressing ScaAgo1. …”
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19873
datasheet1_In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis.docx
Published 2020“…In vitro incubation with LASSBio-1386 reduced the percentage of Leishmania-infected macrophages and the number of intracellular parasites (EC<sub>50</sub> = 9.42 ± 0.64 µM). Also, in vivo treatment of BALB/c mice infected with L. amazonensis resulted in a decrease of lesion size, parasitic load and caused histopathological alterations, when compared to vehicle-treated control. …”
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19874
MK-2206 induced cytotoxicity, inhibited proliferation and was able to overcome the protective effects of the tumor microenvironment.
Published 2012“…<p>When we cultured MM cell lines with indicated concentrations of MK-2206 for 48 hrs we observed dose dependent decrease in <b>A)</b> viability as observed by MTT assays and <b>B)</b> tritiated thymidine uptake indicative of inhibition of proliferation albeit with differences in the sensitivity of cell lines to MK-2206. …”
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19875
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19876
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19877
Allelopathic Effects of Different Plant Water Extracts on Yield and Weeds of Wheat
Published 2018“…In this study, mixtures of allelopathic water extracts of sorghum + sunflower and sorghum + sunflower + mulberry were sprayed each at 12, 15, 18 and 21 L ha-1 at 40 and 55 days after sowing in wheat to control wild oats (Avena fatua), little seed canary grass (Phalaris minor), lamb’s quarters (Chenopodium album) and swine cress (Coronopus didymus). A synthetic herbicide Affinity 50 WP (Carfentrazone-ethyl 0.75% + Isoproturon 50% applied at 1000 g a.i., ha-1) and a weedy check were kept as a control treatment. …”
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19878
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19879
Translation studies with single-molecule resolution.
Published 2019“…The bottom plot shows the temporal dynamics of FRAP, where it can be observed by the abrupt decrease in intensity and a recovery time (<i>τ</i><sub><i>FRAP</i></sub>) correlated with the gene length. …”
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19880
EFFECTS OF SOIL WATER AVAILABILITY AND ORGANIC MATTER CONTENT ON FRUIT YIELD AND SEED OIL CONTENT OF CASTOR BEAN1
Published 2021“…On each experimental unit measuring 100 m2, 50 plants were cultivated with a spacing of 2 m × 1 m (24 useful and 26 border plants). …”