Interplay of gene expression regulation between <i>PRKCZ</i>, <i>IGF1R</i>, and <i>ITGB3</i>. by Kelly K. Y. Seto (723216)

“…To examine if transcript expression of <i>ITGB3</i> is directly regulated by IGF1-signalling, SKOV3 cells were treated with IGF1 (50 ng/ml). (B) The addition of IGF1 had no effect on empty vector control but significantly increased the transcript expression of <i>ITGB3</i> in the PRKCZ-expressing clones when compared to their non-treated counterpart (*<i>p</i> < 0.05). …”

Both CCR4 antagonist (227013) and MEK1/2 inhibitor (PD98059) attenuate the effect induced by C19 and C27. by Yaqi Tan (730337)

“…<p>HUVCEs were cultured for 24 h in media that was added with tumor necrosis factor-α (10 ng/ml) alone or plus C19 (10 nM), C27 (10 nM), 227013 (2 μM), or PD98059 (50 μM). …”

Circulating Th17.1 cells as candidate for the prediction of therapeutic response to abatacept in patients with rheumatoid arthritis: An exploratory research by Shinji Maeda (445222)

“…These novel findings may represent a significant step in the pursuit of precision medicine.…”

Ethyl pyruvate inhibits oxidation of LDL in vitro and attenuates oxLDL toxicity in EA.hy926 cells by Christine Rossmann (4350973)

“…The aim of our study was to investigate whether EP is capable of inhibiting the oxidation of LDL, a crucial step in atherogenesis. Additionally, we examined whether EP attenuates the cytotoxic effects of highly oxidized LDL in the human vascular endothelial cell line EA.hy926.…”

Data_Sheet_1_Combining Lovastatin and Minocycline for the Treatment of Fragile X Syndrome: Results From the LovaMiX Clinical Trial.docx by Camille Champigny (2541178)

“…Significant improvement was noted on the primary outcome measure with a 40% decrease on ABC-C global score with the combined therapy. …”

Chemical structure and properties of screen identified hits. by Simon R. Stockwell (180885)

“…<p><b>A) Compound chemical structures.</b> Compounds are arranged in order of decreasing potency. …”

Riccardin D inhibited angiogenesis in intestinal polyps. by Hui-Ping Liu (290636)

Table_1_Novel Volumetric and Surface-Based Magnetic Resonance Indices of the Aging Brain – Does Male and Female Brain Age in the Same Way?.XLSX by Przemysław Podgórski (7325084)

“…</p><p>Results: In men and women, a decrease in GM and WM volumes and an increase in CSF volume seem to progress slowly since the age of 45. …”

Characterization of advanced glycation end products and their receptor (RAGE) in an animal model of myocardial infarction by Bianca de Moraes Fracasso (6199568)

“…A decrease in yellowish-brown AGEs in heart homogenate was found, which was confirmed by immunodetection of N-ε-carboxymethyl-lysine. …”

Time-frequency analysis comparing encoding of items presented in the left or right visual hemifield. by Malte Kobelt (22086553)

Table_1_Harnessing the Potential of Native Microbial Communities for Bioremediation of Oil Spills in the Iberian Peninsula NW Coast.docx by Maria L. Bôto (10690125)

“…Only a few genera contributed for more than 50% of this genetic potential for aromatic compounds degradation in the enriched communities, namely Alcanivorax, Thalassospira, and Pseudomonas spp. …”

Table_3_Harnessing the Potential of Native Microbial Communities for Bioremediation of Oil Spills in the Iberian Peninsula NW Coast.docx by Maria L. Bôto (10690125)

“…Only a few genera contributed for more than 50% of this genetic potential for aromatic compounds degradation in the enriched communities, namely Alcanivorax, Thalassospira, and Pseudomonas spp. …”

<b>Effect of Marked Weight Loss on Adipose Tissue Biology in People with Obesity and Type 2 Diabetes</b> by Dmitri Samovski (305400)

“…</p><p dir="ltr"><b>Results: </b>Weight loss: <a href="" target="_blank">i) </a><a href="" target="_blank">decreased adipose tissue </a>expression of genes related to extracellular matrix remodeling; ii) decreased adipose tissue expression of SERPINE 1 which encodes plasminogen activator inhibitor-1 (PAI-1); iii) did not decrease adipose tissue immune cell content or expression of genes involved in inflammation; iv) decreased adipose tissue ceramide content; v) decreased plasma <a href="" target="_blank">PAI-1 </a>and leptin concentrations and increased plasma high-molecular weight (HMW) adiponectin; and vi) decreased plasma small extracellular vesicle (sEV) concentration and the sEV content of microRNAs proposed to inhibit insulin action, and completely reversed the inhibitory effect of plasma sEVs on insulin signaling in myotubes.…”

DataSheet1_Investigations of potential non-amino acid SNAT2 inhibitors.docx by Sebastian Jakobsen (17732745)

“…In contrast to the previous publication, MMTC showed no inhibition of SNAT2-mediated ³H-Gly uptake in PC-3 cells at a concentration of 1 or 5 μM, despite a published IC₅₀ of 0.8 µM. …”

Insecticide activity and toxicity of the three <i>Alpinia</i> species essential oils against stored-product insects by Jia-Zhu Wang (17498633)

“…While the EO of <i>A. oxyphylla</i> rhizome (EOAOR) exhibited the highest contact toxicity to <i>L. serricorne</i> (LD₅₀ = 8.06 μg/ adult). …”

Table_2_Harnessing the Potential of Native Microbial Communities for Bioremediation of Oil Spills in the Iberian Peninsula NW Coast.docx by Maria L. Bôto (10690125)

“…Only a few genera contributed for more than 50% of this genetic potential for aromatic compounds degradation in the enriched communities, namely Alcanivorax, Thalassospira, and Pseudomonas spp. …”

The inhibitory effect of hUC-MSCs on intrahepatic cholangiocarcinoma. by Juan Liu (6492)

“…Compared with that of the control, the cell proliferation rate decreased 38.58% (**<i>P</i><0.05; A). Colony-forming assays showed that there were significantly fewer colony-forming units of HCCC-9810 cells treated with conditioned media from hUC-MSCs than that of control cells. …”

Optical coherence tomography angiography findings in malignant hypertensive retinopathy by Berna Dogan (5762903)

“…Visual acuity was 20/63 in the right eye and 20/50 in the left eye. Fundus examination revealed signs of hypertensive retinopathy; thus, a multidisciplinary approach was adopted for the diagnosis and treatment of this patient. …”

Confocal images showing inhibition of BrdU incorporation in BV-2 microglial cells treated with HDAC inhibitor. by Nimmi Baby (524594)

“…The number of BrdU positive cells (E,G);arrows) decreased at 24 h after HDAC inhibitor treatment. Scale bars: 50 µm. …”

FLCN is necessary for the VHL-mediated tumor suppression. by Prabhat Bastola (438804)

“…<p>ShRNA-induced knockdown of FLCN promotes tumor formation by 786-O cells with reconstituted VHL. <b>A.</b> Western blot demonstrating a decrease in FLCN protein expression in cells stably expressing three different FLCN shRNAs as compared to cells transfected with scramble (Scr) control. …”