Bcl-xL siRNA effectively knocks down Bcl-xL mRNA and protein and induces platelet apoptosis. by Shifang Yu (721211)

“…<p>Leukocyte-depleted apheresis platelets (LDPs) were transfected with siBcl-xL or negative control siRNA (siNC) at a final concentration of 50 nM. LDPs without transfection were used as blank controls (control). …”

Characterization of advanced glycation end products and their receptor (RAGE) in an animal model of myocardial infarction by Bianca de Moraes Fracasso (6199568)

“…A decrease in yellowish-brown AGEs in heart homogenate was found, which was confirmed by immunodetection of N-ε-carboxymethyl-lysine. …”

Parasympathetic blockade by methylatropine prevents bradycardia during seizure and in the immediate post-ictal period. by William P. Schilling (7522238)

“…<b>D:</b> The change in heart rate for individual mice in the absence of methylatropine is shown. Note the rapid decrease in heart rate in the clonic period with a further decrease by the end of the tonic period. …”

DataSheet1_Simultaneous silencing of juvenile hormone metabolism genes through RNAi interrupts metamorphosis in the cotton boll weevil.PDF by Daniel D. N. Vasquez (14721448)

“…PEI nanoparticles increased targeted gene silencing compared with naked dsRNAs (up to 80%), whereas CS-TPP-dsRNA nanoparticles decreased gene silencing (0%–20%) or led to the same level of gene silencing as the naked dsRNAs (up to 50%). …”

Interplay of gene expression regulation between <i>PRKCZ</i>, <i>IGF1R</i>, and <i>ITGB3</i>. by Kelly K. Y. Seto (723216)

“…To examine if transcript expression of <i>ITGB3</i> is directly regulated by IGF1-signalling, SKOV3 cells were treated with IGF1 (50 ng/ml). (B) The addition of IGF1 had no effect on empty vector control but significantly increased the transcript expression of <i>ITGB3</i> in the PRKCZ-expressing clones when compared to their non-treated counterpart (*<i>p</i> < 0.05). …”

Differentially expressed genes in <i>Tnfr</i>-deficient glomeruli compared to wildtype after TNF stimulation. by Anela Taubitz (433585)

“…<p>Expression profiling by microarrays was performed on isolated glomeruli from wildtype, <i>Tnfr1,2</i>−/−, <i>Tnfr1</i>−/− and <i>Tnfr2</i>−/− mice after stimulation with 50 ng/ml TNF for 12 hours ex vivo. <b>A:</b> Significance analysis using SAM detected differential regulation of 290 unique genes in <i>Tnfr1,2</i>−/− glomeruli with at least 1.5-fold difference compared to wildtype (black data points). 219 genes were down-regulated (upper left), and 71 genes were up-regulated (lower right). …”

Both CCR4 antagonist (227013) and MEK1/2 inhibitor (PD98059) attenuate the effect induced by C19 and C27. by Yaqi Tan (730337)

“…<p>HUVCEs were cultured for 24 h in media that was added with tumor necrosis factor-α (10 ng/ml) alone or plus C19 (10 nM), C27 (10 nM), 227013 (2 μM), or PD98059 (50 μM). …”

Table_1_Harnessing the Potential of Native Microbial Communities for Bioremediation of Oil Spills in the Iberian Peninsula NW Coast.docx by Maria L. Bôto (10690125)

“…Only a few genera contributed for more than 50% of this genetic potential for aromatic compounds degradation in the enriched communities, namely Alcanivorax, Thalassospira, and Pseudomonas spp. …”

Table_3_Harnessing the Potential of Native Microbial Communities for Bioremediation of Oil Spills in the Iberian Peninsula NW Coast.docx by Maria L. Bôto (10690125)

“…Only a few genera contributed for more than 50% of this genetic potential for aromatic compounds degradation in the enriched communities, namely Alcanivorax, Thalassospira, and Pseudomonas spp. …”

<b>Effect of Marked Weight Loss on Adipose Tissue Biology in People with Obesity and Type 2 Diabetes</b> by Dmitri Samovski (305400)

“…</p><p dir="ltr"><b>Results: </b>Weight loss: <a href="" target="_blank">i) </a><a href="" target="_blank">decreased adipose tissue </a>expression of genes related to extracellular matrix remodeling; ii) decreased adipose tissue expression of SERPINE 1 which encodes plasminogen activator inhibitor-1 (PAI-1); iii) did not decrease adipose tissue immune cell content or expression of genes involved in inflammation; iv) decreased adipose tissue ceramide content; v) decreased plasma <a href="" target="_blank">PAI-1 </a>and leptin concentrations and increased plasma high-molecular weight (HMW) adiponectin; and vi) decreased plasma small extracellular vesicle (sEV) concentration and the sEV content of microRNAs proposed to inhibit insulin action, and completely reversed the inhibitory effect of plasma sEVs on insulin signaling in myotubes.…”

Cell-tracking analysis of ME180 cells upon PilC1- or PilC2-mediated infection. by Philippe C. Morand (260255)

“…<p>ME180 cells were infected (MOI 50) with strains Nm604a or Nm910f that express constitutively either PilC1 or PilC2, and tracked throughout the experiment. …”

DataSheet1_Investigations of potential non-amino acid SNAT2 inhibitors.docx by Sebastian Jakobsen (17732745)

“…In contrast to the previous publication, MMTC showed no inhibition of SNAT2-mediated ³H-Gly uptake in PC-3 cells at a concentration of 1 or 5 μM, despite a published IC₅₀ of 0.8 µM. …”

Insecticide activity and toxicity of the three <i>Alpinia</i> species essential oils against stored-product insects by Jia-Zhu Wang (17498633)

“…While the EO of <i>A. oxyphylla</i> rhizome (EOAOR) exhibited the highest contact toxicity to <i>L. serricorne</i> (LD₅₀ = 8.06 μg/ adult). …”

Table_2_Harnessing the Potential of Native Microbial Communities for Bioremediation of Oil Spills in the Iberian Peninsula NW Coast.docx by Maria L. Bôto (10690125)

“…Only a few genera contributed for more than 50% of this genetic potential for aromatic compounds degradation in the enriched communities, namely Alcanivorax, Thalassospira, and Pseudomonas spp. …”

Biodiversity adaptation indicators averaged globally by partnership scale. by William B. Monahan (313511)

“…Following basic tenets of conservation biology, partnerships promote climate change adaptation by increasing area (A) and environmental heterogeneity (B-D). They also decrease climate-area velocity (E,F) by increasing spatial variation in temperature or precipitation. …”

Changes in capability of cell invasion and alterations in expression of angiogenic, invasive, and survival factors in glioblastoma cells after photofrin based PDT. by Mrinmay Chakrabarti (284359)

“…A significant reduction in the number of invaded cells indicated the decrease in invasive capability of the cells after dose-dependent photofrin based PDT. …”

Optical coherence tomography angiography findings in malignant hypertensive retinopathy by Berna Dogan (5762903)

“…Visual acuity was 20/63 in the right eye and 20/50 in the left eye. Fundus examination revealed signs of hypertensive retinopathy; thus, a multidisciplinary approach was adopted for the diagnosis and treatment of this patient. …”

Confocal images showing inhibition of BrdU incorporation in BV-2 microglial cells treated with HDAC inhibitor. by Nimmi Baby (524594)

“…The number of BrdU positive cells (E,G);arrows) decreased at 24 h after HDAC inhibitor treatment. Scale bars: 50 µm. …”

FLCN is necessary for the VHL-mediated tumor suppression. by Prabhat Bastola (438804)

“…<p>ShRNA-induced knockdown of FLCN promotes tumor formation by 786-O cells with reconstituted VHL. <b>A.</b> Western blot demonstrating a decrease in FLCN protein expression in cells stably expressing three different FLCN shRNAs as compared to cells transfected with scramble (Scr) control. …”

EDCC analysis of circadian microarray data. by Pavlos Stephanos Bekiaris (4732863)

“…ZT0-ZT4 (morning), ZT4-ZT8 (midday), ZT8-ZT12 (evening), ZT12-ZT16 (early night), ZT16-ZT20 (midnight), ZT20-ZT0 (before dawn). B) Decrease of standard deviations of randomized CREs in percent plotted against the number of randomized CREs used (10, 50, 100, 500, and 1000 random CREs, respectively). …”