Net work vs phase of activation and lattice spacing. Top) We simulated work loops in the half sarcomere model at phases of activation of 0 to 0.95 in 0.05 increments, as well as over lattice spacings from 12 to 18 nm and plotted the new work for each condition. Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately.... by Travis Carver Tune (21012349)

“…Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately. …”

The number of Brn3a-expressing cells in retino-collicular co-cultures decreases between DIV4 and DIV12. by Sylvie Voyatzis (332702)

“…(B, C) The density of cells immunoreactive for Brn3a undergoes a reduction of ∼68% between DIV4 and DIV7, and a further decrease of ∼22% between DIV 7 and DIV12. …”

Klf5 expression is down-regulated in the ruptured human and experimental AAA. by Dong Ma (584680)

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

A simple stochastic step model explains Reactive Oxygen Species production in cell populations undergoing senescence and in immortal cells. by Conor Lawless (183686)

“…<p>A) Hypothesis: Schematic representation of a step increase in phenotype for 100 cells. …”

Growth curves (A, strain AWRI R2 (A); B, strain BH8 (B); C, strain Freddo (F)) and accumulated fermentation system mass loss(D, strain A; E, strain B; F, strain F) of <i>S</i>. <i>... by Xiang-yu Sun (748032)

Mitochondrial protein acetylation correlates with a decrease in sirtuin 3 levels. by Mercedes García-Roche (6459200)

Increased expression of Fz5 receptor matched with a decrease in NeuN immunoreactivity at 16w. by Carlos González-Fernández (2794207)

First STEPS: Primary Outcomes of a Randomized, Stepped-Care Behavioral Clinical Trial for Parents of Young Children with New Onset Type 1 Diabetes by Marisa E. Hilliard (5937860)

“…This study evaluated First STEPS, a stepped-care behavioral intervention designed to support parents’ psychosocial functioning and promote children’s glycemic outcomes.…”

Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Preliminary dose-response experiments. by Noelia Torremadé (3687523)

Knock-down of <i>PYCR1</i> decreases growth of CRC cell lines. by Saif Sattar Alaqbi (12055053)

Knock-down of <i>PYCR1</i> decreases proliferation of CRC cell lines. by Saif Sattar Alaqbi (12055053)

Effects of specific anti-miRs for the five miRNAss on the IC50 of cisplatin (A) and paclitaxel (B) in Hec1A cells. by Taek Sang Lee (494682)

Ulk2 morphants have a decreased extension/retraction ratio. by Stacey Lee (647217)

() Cyclic voltammogram for blank, HS-NTA coated step, Ni-NTA coated step and MutS immobilized step in the presence of 5 mM by Minseon Cho (63333)

“…After immobilization of HS-NTA, is increased (open diamond), then formation of Ni-NTA complex causes a decrease of . After immobilization of protein, is re-increased due to interference degree of for the condition of electrode surface. () Blank in the presence of 5 mM . () Cyclic voltammogram and () Nyquist plots measured after the reaction of AT homoduplex and GT heteroduplex. …”

Kinetic Insights into Ammonia Decomposition over Rhodium: A Combined Experimental, Modeling, and Theoretical Study by Fanggang Zhang (22312742)

“…The results demonstrated that reaction rates initially increased with pressure but subsequently exhibited a slight decrease at higher pressures. A thermodynamically consistent microkinetic model consisting of 12 elementary steps was developed, incorporating pressure-dependent adsorption behavior of ammonia. …”

25OHD₃ does not induce vascular calcification in CYP27B1^-/- mice with CKD. by Noelia Torremadé (3687523)

25OHD₃ restores calcium and PTH levels in CYP27B1^-/- mice with CKD. by Noelia Torremadé (3687523)