Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation حسب Kai-li Liu (11378101)

"…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …"

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation حسب Kai-li Liu (11378101)

"…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …"

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation حسب Kai-li Liu (11378101)

"…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …"

Management of Recurrent Bronchopleural Fistula: A Multidisciplinary Approach for A Reconstructive Challenge حسب Karishma Chandarana (4607131)

"…<p> </p> <p>Urgent pneumonectomy for benign disease is rare but highly morbid, with a perioperative mortality approaching 50 percent. …"

Enrichment in genes with concordant responses vs. non-concordant responses between the survival profiling and transcriptome profiling experiments. حسب Alexandra Ketcham (492291)

Temporal and spatial variation of potassium balance in agricultural land at national and regional levels in China حسب Yingxia Liu (792213)

"…<div><p>Linking potassium (K) balance to soil fertility creates a valuable indicator for sustainability assessment in agricultural land-use systems. …"

Hemodynamic parameters. حسب Paulina Kania-Olejnik (19797617)

"…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …"

Tricuspid annular dimensions. حسب Paulina Kania-Olejnik (19797617)

"…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …"

Regional tricuspid annular perimeter. حسب Paulina Kania-Olejnik (19797617)

"…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …"

Preventing value increases for the N matrix (analogous to blocking LTP in D2-SPNs) hinders discrimination learning. حسب Kim T. Blackwell (10915047)

Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan. حسب Brian Onken (86790)

"…On day 15, <i>fbp-1(RNAi)</i> decreases swimming rates by 44%, and <i>pck-2(RNAi)</i> animals moved too slowly to measure (or were dead) (marked as N/A). …"

Deciphering the T790M/L858R-Selective Inhibition Mechanism of an Allosteric Inhibitor of EGFR: Insights from Molecular Simulations حسب Miaomiao Li (483829)

"…The findings might pave the way for designing allosteric drugs targeting EGFR mutant lung cancer patients, which also takes a step forward in terms of drug resistance caused by protein mutations.…"

Deciphering the T790M/L858R-Selective Inhibition Mechanism of an Allosteric Inhibitor of EGFR: Insights from Molecular Simulations حسب Miaomiao Li (483829)

"…The findings might pave the way for designing allosteric drugs targeting EGFR mutant lung cancer patients, which also takes a step forward in terms of drug resistance caused by protein mutations.…"

TcdA-induced Rac1 glucosylation and cytotoxicity are dynamin-dependent. حسب Ramyavardhanee Chandrasekaran (3394916)

"…RT-PCR confirms that siRNA treatment resulted in a decrease in Dyn-1 mRNA expression. <b>(B) Pharmacological inhibition of dynamin GTPases prevents Rac1 modification by TcdA</b>. …"

DataSheet_1_Spliceostatin C, a component of a microbial bioherbicide, is a potent phytotoxin that inhibits the spliceosome.docx حسب Joanna Bajsa-Hirschel (3902302)

"…SPC inhibited the growth of Arabidopsis thaliana seedlings with an IC50 value of 2.2 µM. The seedlings exposed to SPC displayed a significant response with decreased root length and number and inhibition of gravitropism. …"

Aim 2 CBO Personnel Surveys. حسب Natasha Crooks (11047706)

"…</p><p><b>Trial Registration:</b> ClinicalTrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT06266416" target="_blank">NCT06266416</a></p></div>…"

SPIRIT Schedule. حسب Natasha Crooks (11047706)

"…</p><p><b>Trial Registration:</b> ClinicalTrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT06266416" target="_blank">NCT06266416</a></p></div>…"

Study Timeline. حسب Natasha Crooks (11047706)

"…</p><p><b>Trial Registration:</b> ClinicalTrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT06266416" target="_blank">NCT06266416</a></p></div>…"

FUEL Curriculum: Health Promotion Topics. حسب Natasha Crooks (11047706)

"…</p><p><b>Trial Registration:</b> ClinicalTrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT06266416" target="_blank">NCT06266416</a></p></div>…"

Beware the Stick: A Case of a Fractured Nasopharyngeal COVID-19 Screening Swab Lost to a Patient’s Distal Airways حسب Karishma Chandarana (4607131)

"…During swabbing through the tracheostomy tube, the plastic swab-stick snapped in half, and the distal end was lost into the airway.<br><br>A noticeable decrease in oxygenation saturations and increased respiratory effort were escalated to the on-call emergency team. …"