Contrast modulates the cone frequency response—sum of sinusoids (SoS) stimuli. by Marcus H. C. Howlett (3921143)

Potent 5‑Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction by Wenjuan Zhou (115285)

“…After finding a novel inhibitor <b>DC-1</b> with IC₅₀ = 1.2 μM, we performed a series of chemical optimizations, which finally led to the discovery of a potent thiazole containing 5-cyano-6-phenylpyrimidin-based inhibitor <b>DC-2</b> (IC₅₀ = 15 nM). …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

Absence of the ER Cation Channel <i>TMEM38B</i>/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta by Wayne A. Cabral (589450)

“…The disturbed Ca²⁺ flux causes ER stress and increased BiP, and dysregulates synthesis of proband type I collagen at multiple steps. Collagen helical lysine hydroxylation is reduced, while telopeptide hydroxylation is increased, despite increased LH1 and decreased Ca²⁺-dependent FKBP65, respectively. …”

Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma by Bo Li (112195)

“…Herein, we report the structure-guided development of a series of covalent inhibitors of FAK. …”

Solvent accessible surface area. by Jingran Wen (4047724)

Solvent-polyQ hydrogen bond count. by Jingran Wen (4047724)

Table_11_Tramadol’s Inhibitory Effects on Sexual Behavior: Pharmacological Studies in Serotonin Transporter Knockout Rats.PDF by Diana C. Esquivel-Franco (5455082)

Solvent-polyQ hydrogen bond count at the atomic level. by Jingran Wen (4047724)

Intra-polyQ hydrogen bonding. by Jingran Wen (4047724)

BRSV RNA detected in nasal swabs of cows that were naturally re-infected four years after a previous natural BRSV infection (n = 7, reinfection) and cows that were naturally infect... by Sara Hägglund (580500)

Data_Sheet_3_Exploring the active ingredients and pharmacological mechanisms of the oral intake formula Huoxiang Suling Shuanghua Decoction on influenza virus type A based on netwo... by Ruying Tang (14036640)

Data_Sheet_14_Exploring the active ingredients and pharmacological mechanisms of the oral intake formula Huoxiang Suling Shuanghua Decoction on influenza virus type A based on netw... by Ruying Tang (14036640)

Data_Sheet_2_Exploring the active ingredients and pharmacological mechanisms of the oral intake formula Huoxiang Suling Shuanghua Decoction on influenza virus type A based on netwo... by Ruying Tang (14036640)

Number of intra-polyQ hydrogen bonds vs. the number of solvent-polyQ hydrogen bond. by Jingran Wen (4047724)

Secondary structure of polyQ fragments of different lengths. by Jingran Wen (4047724)

CONSORT diagram. by Aurélie Chabanon (5562944)

Mitochondrial proteins <i>in situ</i> tagged with BioID2. by Jan Pyrih (229124)

Psychomotor development of patients with SMA type 2 and 3. by Aurélie Chabanon (5562944)