3‑Hydroxypyridin-4(1<i>H</i>)‑one Derivatives as <i>pqs</i> Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in <i>Pseudomonas aeruginosa</i> by Zhi-Ying Miao (9388615)

“…The most potent derivative <b>16e</b> was identified as a selective inhibitor of the <i>pqs</i> system (IC₅₀ = 3.7 μM) and its related virulence factor pyocyanin (IC₅₀ = 2.7 μM). …”

DNA quality and quantity during the course of IHC staining of FFPE thin sections. by Naoki Einaga (2551768)

The synthetic lethality of the <i>erd1</i>Δ mutation with the Neo1p-depleted <i>cfs1</i>Δ mutation is not caused by reduced levels of cytoplasmic Pi. by Mamoru Miyasaka (9187916)

“…Cells were grown and spotted, as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0236520#pone.0236520.g001" target="_blank">Fig 1B</a>, in YPGA (galactose) or YPDA (glucose) medium with either 20 mM Pi or 50 mM Pi and then incubated at 30°C for 1.5 d. …”

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Management of Recurrent Bronchopleural Fistula: A Multidisciplinary Approach for A Reconstructive Challenge by Karishma Chandarana (4607131)

“…<p> </p> <p>Urgent pneumonectomy for benign disease is rare but highly morbid, with a perioperative mortality approaching 50 percent. …”

Enrichment in genes with concordant responses vs. non-concordant responses between the survival profiling and transcriptome profiling experiments. by Alexandra Ketcham (492291)

Temporal and spatial variation of potassium balance in agricultural land at national and regional levels in China by Yingxia Liu (792213)

“…<div><p>Linking potassium (K) balance to soil fertility creates a valuable indicator for sustainability assessment in agricultural land-use systems. …”

Hemodynamic parameters. by Paulina Kania-Olejnik (19797617)

“…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …”

Tricuspid annular dimensions. by Paulina Kania-Olejnik (19797617)

“…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …”

Regional tricuspid annular perimeter. by Paulina Kania-Olejnik (19797617)

“…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …”

Preventing value increases for the N matrix (analogous to blocking LTP in D2-SPNs) hinders discrimination learning. by Kim T. Blackwell (10915047)

Deciphering the T790M/L858R-Selective Inhibition Mechanism of an Allosteric Inhibitor of EGFR: Insights from Molecular Simulations by Miaomiao Li (483829)

“…The findings might pave the way for designing allosteric drugs targeting EGFR mutant lung cancer patients, which also takes a step forward in terms of drug resistance caused by protein mutations.…”

Deciphering the T790M/L858R-Selective Inhibition Mechanism of an Allosteric Inhibitor of EGFR: Insights from Molecular Simulations by Miaomiao Li (483829)

“…The findings might pave the way for designing allosteric drugs targeting EGFR mutant lung cancer patients, which also takes a step forward in terms of drug resistance caused by protein mutations.…”

TcdA-induced Rac1 glucosylation and cytotoxicity are dynamin-dependent. by Ramyavardhanee Chandrasekaran (3394916)

“…RT-PCR confirms that siRNA treatment resulted in a decrease in Dyn-1 mRNA expression. <b>(B) Pharmacological inhibition of dynamin GTPases prevents Rac1 modification by TcdA</b>. …”

DataSheet_1_Spliceostatin C, a component of a microbial bioherbicide, is a potent phytotoxin that inhibits the spliceosome.docx by Joanna Bajsa-Hirschel (3902302)

“…SPC inhibited the growth of Arabidopsis thaliana seedlings with an IC50 value of 2.2 µM. The seedlings exposed to SPC displayed a significant response with decreased root length and number and inhibition of gravitropism. …”

Aim 2 CBO Personnel Surveys. by Natasha Crooks (11047706)

“…</p><p><b>Trial Registration:</b> ClinicalTrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT06266416" target="_blank">NCT06266416</a></p></div>…”

SPIRIT Schedule. by Natasha Crooks (11047706)

“…</p><p><b>Trial Registration:</b> ClinicalTrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT06266416" target="_blank">NCT06266416</a></p></div>…”