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9241
Antibodies to PfRH5 and PfCyRPA modify temporal aspects of the pre- and post-invasion phases of <i>Plasmodium falciparum</i> into human RBCs.
Published 2023“…<p>(A-E) The invasion steps being monitored from live cell videos of antibody-treated parasites are indicated on the y-axes. …”
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9242
Unwinding of DsrA+S complex
Published 2011“…</p><p>© 2007 The Author(s)</p> () Schematic representation of I+DsrA melting by Hfq. () 25 nM I+DsrA complex was prepared in T50 buffer. …”
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9243
Lysine Mutation of the Claw-Arm-Like Loop Accelerates Catalysis by Cellobiohydrolases
Published 2019“…Lysine mutation of Thr393 in <i>Talaromyces emersonii</i> CBHI (<i>Te</i>Cel7A) performed similarly. Lysine approaches the catalytic area and stabilizes the Michaelis complex, potentially affecting glycosylation, the rate-limiting step of the catalytic cycle. …”
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9244
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9245
Iron(III) Complexes of Tripodal Monophenolate Ligands as Models for Non-Heme Catechol Dioxygenase Enzymes: Correlation of Dioxygenase Activity with Ligand Stereoelectronic Properti...
Published 2009“…Also, when the substituents on the phenolate arm are varied to tune the Lewis acidity of iron(III) center, the reaction rate decreases with decrease in Lewis acidity and, interestingly, extradiol cleavage is also observed when the Lewis acidity is decreased further by incorporating a 3,5-dimethylphenolate arm as in <b>6</b>.…”
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9246
Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor
Published 2015“…We recently reported that amino acids (a.a.) 50-250 of the NTD are capable of modulating AR nucleocytoplasmic trafficking. …”
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9247
Mixed Ligand Copper(II) Complexes of <i>N</i>,<i>N</i>-Bis(benzimidazol-2-ylmethyl)amine (BBA) with Diimine Co-Ligands: Efficient Chemical Nuclease and Protease Activities and Cyto...
Published 2012“…The highest efficiency of <b>3</b> to cleave both DNA and protein in the presence of H<sub>2</sub>O<sub>2</sub> is consistent with its strong hydrophobic interaction with the biopolymers. The IC<sub>50</sub> values of <b>1</b>–<b>4</b> against cervical cancer cell lines (SiHa) are almost equal to that of cisplatin, indicating that they have the potential to act as effective anticancer drugs in a time-dependent manner. …”
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9248
Mixed Ligand Copper(II) Complexes of <i>N</i>,<i>N</i>-Bis(benzimidazol-2-ylmethyl)amine (BBA) with Diimine Co-Ligands: Efficient Chemical Nuclease and Protease Activities and Cyto...
Published 2012“…The highest efficiency of <b>3</b> to cleave both DNA and protein in the presence of H<sub>2</sub>O<sub>2</sub> is consistent with its strong hydrophobic interaction with the biopolymers. The IC<sub>50</sub> values of <b>1</b>–<b>4</b> against cervical cancer cell lines (SiHa) are almost equal to that of cisplatin, indicating that they have the potential to act as effective anticancer drugs in a time-dependent manner. …”
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9249
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9250
DataSheet1_Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disord...
Published 2021“…In a second, independent study sample of 50 patients who underwent amitriptyline therapy of 75 mg twice daily, a significant trend of increasing amitriptyline plasma concentrations with decreasing OCT1 activity was observed (p = 0.018), while nortriptyline plasma concentrations were unaffected by the OCT1 genotype. …”
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9251
Self-renewal and differentiation of neural stem/progenitor cells.
Published 2015“…Error bars represent SD. Scale bars, 50 μm. <b>K and L,</b> Neurosphere formation from cortical cells isolated from <i>Nestin;Epha4</i><sup><i>fx/fx</i></sup> cortex in the presence of FGF2 alone, clustered ephrin-A1 alone, or FGF2 plus clustered ephrin-A1. …”
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9252
ConPADE: Genome Assembly Ploidy Estimation from Next-Generation Sequencing Data
Published 2015“…<div><p>As a result of improvements in genome assembly algorithms and the ever decreasing costs of high-throughput sequencing technologies, new high quality draft genome sequences are published at a striking pace. …”
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9253
Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells
Published 2017“…Cisplatin IC<sub>50</sub> in A549Pt (parental) and A549cisR (cisplatin resistant) cells was 13 μM and 47 μM, respectively. …”
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9254
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9255
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9256
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9257
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9258
Data_Sheet_1_HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis.docx
Published 2021“…No significant association with ankylosing spondylitis was observed for the PCSK9 score (OR, 0.89; 95% CI, 0.68–1.16) and the NPC1L1 score (OR, 1.50; 95% CI, 0.39–5.77). For the LDL score, genetically determined per mmol/L decrease in LDL cholesterol levels led to a reduced risk of ankylosing spondylitis (OR, 0.64; 95% CI, 0.43–0.94), with significant heterogeneity and pleiotropy in the estimate. …”
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9259
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9260