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step decrease » sizes decrease (Expand Search), teer decrease (Expand Search)
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5641
Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells
Published 2024“…Herein, a series of celastrol urea derivatives were developed based on its cocrystal structure with PRDX1, with the aim of pursuing a PRDX1-specific inhibitor. …”
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5642
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5643
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5644
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5645
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5646
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5647
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5648
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5649
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5650
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5651
Aβ42-induced down-regulation of K<sub>v</sub>4 protein is mediated by a proteasome and lysosome-dependent pathway.
Published 2015“…The K<sub>v</sub>2-K<sub>v</sub>3 DR component was recorded using a prepulse of -45 mV to completely inactivate K<sub>v</sub>4 channels, before stepping to a test potential of +50 mV; the K<sub>v</sub>4 current was then isolated by subtracting this DR component from the total whole-cell current elicited from a prepulse of -125 mV, stepping to a test potential of +50 mV. …”
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5652
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5653
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5654
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5655
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines
Published 2017“…Using high-throughput screening, a chemical library containing natural products was interrogated for inhibition of the RGS17–Gα<sub>o</sub> interaction. …”
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5656
Histograms showing natural genetic variation of life history traits using adjusted means.
Published 2013“…<p>(a) Primary dormancy (days): measured by number of days required to reach 50% of germination (DSDS50). …”
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5657
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5658
Image_2_TRIM50 Suppresses Pancreatic Cancer Progression and Reverses the Epithelial-Mesenchymal Transition via Facilitating the Ubiquitous Degradation of Snail1.tif
Published 2021“…Tripartite motif-containing 50 (TRIM50) is a member of the TRIM family, but little is known regarding its expression and potential functional roles in cancer. …”
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5659
Image_1_TRIM50 Suppresses Pancreatic Cancer Progression and Reverses the Epithelial-Mesenchymal Transition via Facilitating the Ubiquitous Degradation of Snail1.tif
Published 2021“…Tripartite motif-containing 50 (TRIM50) is a member of the TRIM family, but little is known regarding its expression and potential functional roles in cancer. …”
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5660
Image_3_TRIM50 Suppresses Pancreatic Cancer Progression and Reverses the Epithelial-Mesenchymal Transition via Facilitating the Ubiquitous Degradation of Snail1.tif
Published 2021“…Tripartite motif-containing 50 (TRIM50) is a member of the TRIM family, but little is known regarding its expression and potential functional roles in cancer. …”