Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest by Lin Piao (4452487)

“…In both heart and brain, CA increased lactate concentrations (1.9-fold and 3.1-fold increase, respectively, <i>P</i><0.01), decreased PDH enzyme activity (24% and 50% reduction, respectively, <i>P</i><0.01), and increased PDK protein expressions (1.2-fold and 1.9-fold, respectively, <i>P</i><0.01). …”

Pooling observations. by Stijn Bruneel (8113409)

Percent differences between the fixed and climate adaptive harvest management strategies in mean biomass and cumulative harvest at different time intervals in the simulations. by Jameal F. Samhouri (10136090)

“…<p>Percent differences in mean biomass and cumulative harvest between the fixed and climate adaptive harvest management strategies for 16-year time intervals throughout the 50-year simulations in populations subject to a gradual decrease in (a) carrying capacity, (c) productivity, (e) both carrying capacity and productivity, or a gradual increase in (b) carrying capacity, (d) productivity, (f) both carrying capacity and productivity. …”

Improvement of physical and sensory properties of whipping cream by replacing sucrose with rebaudioside A, isomalt and maltodextrin by Mohamad Hossein AHOUEI (5996381)

“…Samples containing different amounts of rebaudioside A, isomalt and maltodextrin (50% Rebaudioside A+50%Isomalt, 50% Rebaudioside A +50%Maltodextrin, 50% Rebaudioside A +25%Isomalt+25% Maltodextrin, 60% Rebaudioside A +40%Isomalt, 60% Rebaudioside A +40% Maltodextrin, 60% Rebaudioside A +20%Isomalt+20% Maltodextrin) were stored for two months. …”

Improvement of physical and sensory properties of whipping cream by replacing sucrose with rebaudioside A, isomalt and maltodextrin by Mohamad Hossein AHOUEI (5996381)

“…Samples containing different amounts of rebaudioside A, isomalt and maltodextrin (50% Rebaudioside A+50%Isomalt, 50% Rebaudioside A +50%Maltodextrin, 50% Rebaudioside A +25%Isomalt+25% Maltodextrin, 60% Rebaudioside A +40%Isomalt, 60% Rebaudioside A +40% Maltodextrin, 60% Rebaudioside A +20%Isomalt+20% Maltodextrin) were stored for two months. …”

Image1_Phytochemical and toxicological evaluation of Zephyranthes citrina.JPEG by Muhammad Haseeb Ur Rehman (13848379)

“…Uric acid was raised at a dose of 100 mg/kg. In acute toxicity, at 2000 mg/kg, creatinine and uric acid increased while urea levels decreased. …”

IC₅₀ values of REJO SP mutants vs. WT by MAbs targeting V2i, V3, V2q, and the CD4bs and by CD-IgG2. by Chitra Upadhyay (817121)

“…IC₅₀ (μg/ml) values that increase or decrease by >3 fold and p<0.05 as compared to that of WT by the same MAbs or CD4-IgG2 are shown in red and blue. …”

Advantages of our purification method over silica column purification and phenol-chloroform extraction. by Zhe F. Tang (21021785)

“…<p>(A) Sizes of select bands in the 1kb+ ladder for quick reference. …”

Fig 6 - by Xiu-Qi Chen (13832389)

Proportion of parental line (A receptor and R pollinator) seeds improving rice hybrid production by Adriano Stephan Nascente (4647931)

“…Treatments included six proportions of seeds of the INTA Puita (0.75, 1.5, 3.0, 6.0, 12.0, and 24.00%) mixture with seeds of line 464 A (99.25, 98.50, 97.00, 94.00, 88.00, and 76%, respectively). …”

(A) Soil bin experiment site; (B) Air cannon cracking effect^‌‌. by Xia Li (14984)

Additional measures to characterize (A) actin filament and (B) motor protein organization in simulations using baseline parameter values (Table 1). by Maria-Veronica Ciocanel (9565099)

“…The parameter values used are <i>d</i>_step = 6 nm, <i>k</i>_head.bind = 0.2/s, <i>F</i>_s = 100 pN, range_heads = 15–30 (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1010026#pcbi.1010026.t001" target="_blank">Table 1</a>). …”

Fig 2 - by Mengnan Lu (12128694)

The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy by Simon J. A. van Kuijk (2938218)

“…<div><p>Carbonic anhydrase IX (CAIX) is a tumor-specific protein that is upregulated during hypoxic conditions where it is involved in maintaining the pH balance. …”

Effects of riluzole on <i>I_NaP</i> and <i>I_NaT</i> in A-type neurons of the compressed DRG. by Rou-Gang Xie (179362)

“…<p>(A) Traces of <i>I_NaP</i> (bottom) induced by increasing applied voltage (top) in a compressed DRG neuron in the absence (control) and presence of riluzole (2, 10, 50 µM). …”

Dehydrozingerone Improves Mood and Memory in Diabetic Mice via Modulating Core Neuroimmune Genes and Their Associated Proteins by Anuradha Kesharwani (21386000)

“…Additionally, anomalies in the glutamine-glutamate/GABA cycle could exacerbate diabetes-related cognitive deficits. Treatment with DH had a variety of advantages, including decreased neuroinflammation and neuronal cell death as well as the promotion of critical genes and proteins necessary to promote cognitive performance. …”

Illustration of household-based strategy. by Callum Shaw (15628313)

Excel spreadsheet containing, in separate sheets, the underlying numerical data and statistical analysis for Figs 1–7 and all supplemental figures. by Brandon F. Keele (7450001)

Barcode distribution and plasma viral load dynamics of 3 noncontrolling RMs. by Brandon F. Keele (7450001)