Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

KS1 and KS2 combined RNA-seq experiment differentially expressed genes: <i>Kmt2d</i>^<i>-/-</i> vs <i>Kmt2d</i>^<i>+/+</i>, Day 7. by Christine W. Gao (18794576)

Developmental toxicity induced by 2 μg/ml propofol. by Yali Ge (417371)

Superposition of conserved PARG1 C1-RhoGAP domains bound to RhoA protein. by Zen Kouchi (14898435)

RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice by Jaime Gutiérrez (401710)

“…<div><p>Fibroblasts are critical for wound contraction; a pivotal step in wound healing. They produce and modify the extracellular matrix (ECM) required for the proper tissue remodeling. …”

Impact of age on sharing of top 5000 TCRβ clones. by Sarah A. Johnson (11355817)

Serum cholesterol concentrations in hyperthyroid cats and euthyroid controls. by Molly A. Bechtold (18794251)

Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency by Caiping Zhang (6745976)

Genetic deletion of Bin1 in neurons alters neuronal activation <i>in vivo</i>. by Kathleen M. McAvoy (7224863)

PPM1A facilitates both nuclear distribution and transcription potency of YAP/TAZ. by Ruyuan Zhou (10197187)

“…<b>(B–D)</b> Transcription potency of YAP (5 ng), which was suppressed by coexpression of MST1 (50 ng) (B), LATS1 (500 ng) (C), or MAP4K1 (50 ng) (D), was markedly recovered by cotransfection of wild-type PPM1A but not the enzyme-dead PPM1A (D239N). …”

Effect of different nitrate levels on spinach. by Kangning Han (12001445)

“…This study aimed to elucidate the regulatory mechanisms of nitrate stress tolerance in spinach (<i>Spinacia oleracea</i> L.). We studied the effects of exogenous application of 15 (control), 50, 100, 150, 200, and 250 mM NO₃^- on spinach growth, physiology, and photosynthesis. …”

Inhibition of FleA by 2EHex or fucose results in a loss of mucin binding and greatly reduced phagocytosis by macrophages. by Sheena C. Kerr (495450)

“…<p>(A) Structures of fucopyranoside compounds. (B) Amount of compound required to inhibit binding of labeled FleA to mucin by 50% (IC50 [μM]). …”

Result of whole-mount <i>in situ</i> hybridization at 48 hpf. by Yali Ge (417371)

(A, B) Western blot analysis of lysates from the two clones with the TrkB-BAC minigene (77−5 and 77−6) before and after deglycosylation and probed with an antibody recognizing TrkB... by Francesco Tomassoni-Ardori (22216521)

Parallel testing of (a) cell vitality with MTT- and (b) membrane disruption with the LDH-assay at different time points (2 min, 15 min, 30 min, 2 h, 4 h, 24 h) and concentrations (... by Lars Steinstraesser (20161)

“…<p>The membrane integrity of the cells after incubation with [D]-K₃H₃L₉ at the LD₅₀ in 2 and 4 multiples showed a parabolic curve progression with over hundred percent LDH release after 24 h. …”

Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Annulation of Aryl Halides to Furnish Indolines by Yuanfeng Li (217864)

“…This dearomative Heck protocol, which tolerates a broad variety of functional groups, is amenable to the generation of optically active indoline derivatives bearing all-carbon quaternary stereogenic centers in one step in moderate to excellent yields, with excellent diastereoselectivities (>20:1) and enantioselectivities (up to >99% ee). …”

Effect of NaCl on the oligomeric mass/size of <i>M</i>. <i>leprae</i> HSP18. by Sandip Kumar Nandi (713237)

Initial placements distributions, conditional on field. by Sergey V. Popov (6719075)