Interactive Model Implementation using Artistoo. by Leonie van Steijn (10142786)

Graphs of the dimensional changes of the lens from the 20-year-old donor. by Ronald A. Schachar (16674576)

Adhesion growth dynamics influence adhesion cluster size and localisation, cell speed and MSD. by Leonie van Steijn (10142786)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Schematic representation of the effect of adhesion on cell propulsion strength. by Leonie van Steijn (10142786)

Persistence times obtained from fitting MSD with Fürth with translational diffusion (Eq 2) against adhesion area for different values of <i>p</i>_<i>s</i> and λ<sub><i>ad... by Leonie van Steijn (10142786)

S1 Movie legend - by Ronald A. Schachar (16674576)

“…When equatorial zonular (Ez) force was increased in 3.125 x 10^-6 N steps while the anterior zonular (Az) and posterior zonular (Pz) forces were decreased in 3.125 x 10^-6 N steps, COP was evaluated. …”

MSD for initial and extended model with fits of Eqs 2 and 4. by Leonie van Steijn (10142786)

Overview of the adhesion processes within the model. by Leonie van Steijn (10142786)

Model implementation in Tissue Simulation Toolkit. by Leonie van Steijn (10142786)

Adhesion growth dynamics influence adhesion cluster size and localisation, cell speed and MSD. by Leonie van Steijn (10142786)

Simulations of the model without adhesion-propulsion feedback. by Leonie van Steijn (10142786)

Overview of the motility modes possible in the model and which parameters govern the transitions between them. by Leonie van Steijn (10142786)

Simulations of the model with adhesion-propulsion feedback. by Leonie van Steijn (10142786)

Fitted values of <i>α</i> from Eq 4 for different values of λ_<i>adh</i> and <i>p</i>_<i>s</i>. by Leonie van Steijn (10142786)

Effect of perimeter constraint, λ_<i>P</i> and cell-medium interfacial energy <i>J</i>_{<i>cell</i>,<i>medium</i>} on cell behaviour. by Leonie van Steijn (10142786)

Mean speed, diffusion coefficient, and mean adhesive area change by increasing <i>p</i>_<i>s</i> and λ_<i>adh</i>. by Leonie van Steijn (10142786)