Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways... by So Youn Park (141327)

“…Time-dependent increases in the expression of JAK2 phosphorylated at Tyr1007/1008 (P-JAK2) in activated N2a Swe cells. <b>C</b> and <b>D</b>. Concentration-dependent decreases in P-JAK2 expression by taxifolin (10 ~ 50 μM), cilostazol (10 ~ 50 μM), and 20 μM AG490 (a JAK2 inhibitor) determined after culture in medium containing 1% FBS for 3 hr. …”

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication by Peili Hou (4737219)

“…However, how SARS-CoV-2 mediates the subversion of the macroautophagy/autophagy pathway remains largely unclear. In this study, we demonstrate that overexpression of the SARS-CoV-2 ORF7a protein activates LC3-II and leads to the accumulation of autophagosomes in multiple cell lines, while knockdown of the viral <i>ORF7a</i> gene via shRNAs targeting <i>ORF7a</i> sgRNA during SARS-CoV-2 infection decreased autophagy levels. …”

Spatiotemporal spike sorting on multi-electrode array (MEA) data: Uniform Manifold Approximation and Projection (UMAP) vs. SpyKING CIRCUS (SC). by Daniel Suárez-Barrera (22676654)

“…The average F1 score matrix from different MEA recordings shows a similar gradual decrease, emphasizing UMAP’s ability to detect signals at larger distances from the GT neuron. …”

Loss of <i>amx</i> causes shortening of lifespan and age-dependent neurophysiological defects. by Jose L. Salazar (3233190)

Cation Charge Density and Precatalyst Selection in Group 2-Catalyzed Aminoalkene Hydroamination by Merle Arrowsmith (1660063)

“…The rate of cyclization was also found to decrease with increasing substrate concentration. This latter observation, along with the observation of large kinetic isotope effects (>4), proposed to be a result of a beneficial and concerted proton transfer step associated with rate-determining alkene insertion, are reasoned to be consistent with Michaelis−Menten-type kinetics.…”

Expression of mechanosensitive channels in the <i>X</i>. <i>laevis</i> retina. by Ulisse Bocchero (9128127)

Effect of berberine on mouse pronuclear embryonic development <i>in vitro</i>. by Chao Zhang (51048)

AUT00201 (1 µM) can rescue AP width in cuprizone mice. by Sara Hijazi (21656615)

“…<p><b>A</b>. Bath application of AUT00201 1 µm decreased the rheobase of PV interneurons from cuprizone mice but not control mice (<i>group x AUT00201 two-way repeated measures: n = 12,13 cells from 4 mice per group: F(1,12) = 0.1816, p = 0.6775; AUT00201 effect: F(1,12) = 7.122, *p = 0.0205. …”

IFT43 plays a distinct role in IFT-A transport. by Bing Zhu (145649)

“…Data are presented as mean ±SD (n = 50 cells).n.s.(<i>p</i>>0.05); ***, <i>p</i><0.001(student’s <i>t</i>-test).…”

Diet composition. by Clare L. Adam (684674)

Percentage of post-menopausal women still free from IBC diagnosis relative to the duration of clinical study (years of follow-up) in 14 studies (16 outcomes) comprising 1,808,022 w... by Winnifred Cutler (759887)

5-hmC is increased during THP1 macrophage differentiation. by Fangfang Sun (2410654)

DNA damage in c-kit-positive stem cells and cardiomyocytes on heart sections. by Lan Luo (191328)

Comparison between juvenile and adult demyelination. by Sara Hijazi (21656615)

“…<p><b>A–I</b>. Juvenile demyelination leads to impairment in PV interneuron maturation whereas adult demyelination induces a decrease in the excitability of PV interneurons. …”

Fluorescence emitted by the calcium-sensitive indicator, CaSiR-1, incorporated into rods isolated from the <i>Xenopus laevis</i> retina. by Ulisse Bocchero (9128127)

DataSheet1_Zebrafish EEG predicts the efficacy of antiepileptic drugs.pdf by Jun-Nyeong Shin (14234054)

“…The antiepileptic effect was determined by observing a significant decrease in at least one out of three indicators of the number, total duration, and mean duration of ictal events.…”

Semicontinuous Automated Measurement of Organic Carbon in Atmospheric Aerosol Samples by Chao Lu (4374)

“…The IC background can often be small and sufficiently constant to be corrected for, without separate measurement, by a blank subtraction. The organic material is now oxidized stepwise or in one step to CO₂. …”

Semicontinuous Automated Measurement of Organic Carbon in Atmospheric Aerosol Samples by Chao Lu (4374)

“…The IC background can often be small and sufficiently constant to be corrected for, without separate measurement, by a blank subtraction. The organic material is now oxidized stepwise or in one step to CO₂. …”

Ductal branching is dependent upon phenotype heterogeneity within MCF10A in 3-D culture. by Russell Gould (3603524)

“…For compaction and tubular assays, cells were embedded into collagen gels for 72 hrs, and the extent of tubulogenesis was measured at 7 days. (A-D) Within MCF10A, TGF−<i>β</i>2 (10ng/ml) enhanced invasion and contractile properties while, VEGFA (50ng/ml) promoted increased migration. …”

Ubr3 is required for Hh signaling and proper optic vesicle morphogenesis. by Tongchao Li (115391)