Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

<i>C</i>. <i>sinensis</i> enhanced bile duct and liver injury through TLR2 pathway. by Yuru Wang (846969)

Effect of high-intensity interval training on glycemic control in adults with type 1 diabetes with overweight or obesity: a randomized controlled trial with partial cross-over by Angela S Lee (8996732)

“…In participants who undertook at least 50% of the prescribed HIIT intervention, the HbA1c reduction was significantly greater than control (HIIT -0.64 ± 0.64% (n=9), control -0.14 ± 0.48% (n=15), p=0.04). …”

Superposition of conserved PARG1 C1-RhoGAP domains bound to RhoA protein. by Zen Kouchi (14898435)

Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency by Caiping Zhang (6745976)

Genetic deletion of Bin1 in neurons alters neuronal activation <i>in vivo</i>. by Kathleen M. McAvoy (7224863)

Effect of different nitrate levels on spinach. by Kangning Han (12001445)

“…This study aimed to elucidate the regulatory mechanisms of nitrate stress tolerance in spinach (<i>Spinacia oleracea</i> L.). We studied the effects of exogenous application of 15 (control), 50, 100, 150, 200, and 250 mM NO₃^- on spinach growth, physiology, and photosynthesis. …”

Result of whole-mount <i>in situ</i> hybridization at 48 hpf. by Yali Ge (417371)

(A, B) Western blot analysis of lysates from the two clones with the TrkB-BAC minigene (77−5 and 77−6) before and after deglycosylation and probed with an antibody recognizing TrkB... by Francesco Tomassoni-Ardori (22216521)

RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice by Jaime Gutiérrez (401710)

“…<div><p>Fibroblasts are critical for wound contraction; a pivotal step in wound healing. They produce and modify the extracellular matrix (ECM) required for the proper tissue remodeling. …”

Effects of nano-curcumin on cell cycle and apoptosis in breast cancer cells. by Taraneh Givi (22793530)

Effects of nano-curcumin on cell migration. by Taraneh Givi (22793530)

Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Annulation of Aryl Halides to Furnish Indolines by Yuanfeng Li (217864)

“…This dearomative Heck protocol, which tolerates a broad variety of functional groups, is amenable to the generation of optically active indoline derivatives bearing all-carbon quaternary stereogenic centers in one step in moderate to excellent yields, with excellent diastereoselectivities (>20:1) and enantioselectivities (up to >99% ee). …”

The impact of nano-curcumin on cell viability and proliferation in breast cancer cells. by Taraneh Givi (22793530)

Effects of different concentrations of propofol on the survival rate of zebrafish embryos and larvae. by Yali Ge (417371)

Schematic of fixture. by Shaheer Ahmed Khan (17797647)

“…The tensile strength of ABS polymer decreases as the traverse speed increases from 10 mm/min to 50 mm/min at both rotational speeds of 800 and 1200 rpm. …”

Experimentation plan. by Shaheer Ahmed Khan (17797647)

“…The tensile strength of ABS polymer decreases as the traverse speed increases from 10 mm/min to 50 mm/min at both rotational speeds of 800 and 1200 rpm. …”